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Journal of Clinical Medicine, Volume 7, Issue 2

February 2018 - 26 articles

Cover Story: The cover image represents 'moonlighting' by WDR5, a highly conserved protein that was first characterized in the context of histone methylation, but is now known to also act as a reader of the epigenetic 'code', a component of multiple chromatin modifying complexes, a co-factor for transcriptional regulators, and in mitotic regulation. We review the known functions of WDR5, discuss how a small, conserved, protein can achieve such versatility, consider how the multi-faceted actions of WDR5 need to be carefully considered when interpreting experimental results, and describe prospects for WDR5 as a target for anti-cancer agents. View this paper
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Articles (26)

  • Feature Paper
  • Article
  • Open Access
17 Citations
6,774 Views
7 Pages

20 February 2018

Although HbA1c is widely used as a glycemic control indicator, HbA1c is known to show falsely high levels in patients in an iron deficient state (IDS). We compared the influence of IDS on HbA1c levels between pregnant women, due to mainly an increase...

  • Feature Paper
  • Review
  • Open Access
34 Citations
8,332 Views
11 Pages

20 February 2018

The incidence of β-thalassemia in Sardinia is high and β-39 is the most common mutation. The prevention campaign started in 1977 and was performed in a single center (Microcitemico Hospital, Cagliari, Sardinia, Italy). It was based on educational pro...

  • Article
  • Open Access
22 Citations
4,654 Views
6 Pages

20 February 2018

Objectives: Evidence of mitochondrial respiratory chain (MRC) dysfunction and oxidative stress has been implicated in the pathophysiology of multiple sclerosis (MS). However, at present, there is no reliable low invasive surrogate available to evalua...

  • Article
  • Open Access
16 Citations
4,094 Views
10 Pages

Long-Term Oncologic Outcomes, Opioid Use, and Complications after Esophageal Cancer Surgery

  • Tak Kyu Oh,
  • Kwhanmien Kim,
  • Sang Hoon Jheon,
  • Sang-Hwan Do,
  • Jung-Won Hwang,
  • Young-Tae Jeon,
  • Kooknam Kim and
  • In-Ae Song

19 February 2018

Effective and adequate opioid use and prevention of postoperative complications are important for enhanced recovery after surgery. We examined the effects of postoperative opioid use and postoperative complications on overall survival and recurrence-...

  • Feature Paper
  • Review
  • Open Access
2 Citations
4,881 Views
8 Pages

12 February 2018

Non-surgical left atrial appendage occlusion has emerged as an alternative to anticoagulant therapy in the management of stroke risk in patients with atrial fibrillation. This review reports on some of the more common devices that are currently being...

  • Review
  • Open Access
35 Citations
10,792 Views
15 Pages

A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents

  • Stephanie A. Joppa,
  • Justin Salciccioli,
  • Jill Adamski,
  • Salma Patel,
  • Waldemar Wysokinski,
  • Robert McBane,
  • Farah Al-Saffar,
  • Heidi Esser and
  • Fadi Shamoun

11 February 2018

Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin w...

  • Article
  • Open Access
32 Citations
10,387 Views
8 Pages

11 February 2018

This study aimed to describe the experiences of nurses in hemodialysis care. In this phenomenological study, purposive sampling began and continued until data saturation. The research environment was the Hemodialysis unit. Data was collected through...

  • Article
  • Open Access
16 Citations
5,482 Views
7 Pages

Canaloplasty in Corticosteroid-Induced Glaucoma. Preliminary Results

  • Paolo Brusini,
  • Claudia Tosoni and
  • Marco Zeppieri

11 February 2018

Purpose: to present the mid-term results of canaloplasty in a small cohort of corticosteroid glaucoma patients. Material and Methods: Nine eyes from seven patients with various types of corticosteroid glaucoma in maximum medical therapy underwent can...

  • Editorial
  • Open Access
2 Citations
3,580 Views
2 Pages

9 February 2018

With this Editorial we want to present the Special Issue “Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis” to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement com...

  • Article
  • Open Access
28 Citations
9,042 Views
11 Pages

Mental Health Effects of Stress over the Life Span of Refugees

  • Michael Hollifield,
  • Teddy D. Warner,
  • Barry Krakow and
  • Joseph Westermeyer

6 February 2018

Information about the relative impact of stressful events across the lifespan on the mental health of refugees is needed. Cross-sectional data from a community sample of 135 Kurdish and 117 Vietnamese refugees were fit to a path model about the effec...

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J. Clin. Med. - ISSN 2077-0383