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Article

Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis

by
Naoyuki Yamaguchi
1,†,
Takuki Sakaguchi
2,*,†,
Miki Taira
3,
Daisuke Fukuda
1,4,5,
Ken Ohnita
1,6,
Tatsuro Hirayama
3,
Kazuo Yashima
2,
Hajime Isomoto
1,2 and
Kazuhiro Tsukamoto
3
1
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biological Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
2
Department of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
3
Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
4
Department of Surgical Oncology, Nagasaki University Graduate School of Biological Science, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
5
Fukuda Yutaka Clinic, 3-5 Hamaguchi-machi, Nagasaki 852-8107, Japan
6
Shunkaikai Inoue Hospital, 6-12 Takara-machi, Nagasaki 850-0045, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(2), 629; https://doi.org/10.3390/jcm13020629
Submission received: 27 November 2023 / Revised: 9 January 2024 / Accepted: 19 January 2024 / Published: 22 January 2024
(This article belongs to the Special Issue Recent Diagnostic and Therapeutic Advances in Gastrointestinal-Disease-Related Gut Microbiota and Helicobacter)
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Abstract

Cytotoxin-associated gene A (CagA) is an oncoprotein that H. pylori injects into the host’s gastric epithelial cells and that induces proinflammatory cytokines, such as interleukin (IL)-18 and IL-1β. As a result, it leads to atrophic gastritis (AG), a precancerous lesion of gastric cancer. On the other hand, host cells degrade CagA using autophagy systems. However, few studies exist about the single nucleotide polymorphisms (SNPs) in MAP1LC3A, MAP1LC3B, ATG4A, ATG4B, ATG4C, ATG7, and ATG13, which belong to the autophagy-related genes concerning AG. This study aimed to detect biomarkers associated with AG. Herein, H. pylori-positive subjects (n = 200) were divided into the AG (n = 94) and non-AG (n = 106) groups. Thirty tag SNPs were selected from the above seven candidate genes. The SNP frequency between the two groups was analyzed. The frequency of the C/T or T/T genotype at rs4683787 of ATG7 was significantly lower in the AG group than in the non-AG group (p = 0.034, odds ratio = 0.535). Based on multivariate analysis, the C/C genotype of rs4684787 and age were independently associated with gastric mucosal atrophy. This finding helps stratify the patients needing timely endoscopic screening or early eradication of H. pylori.
Keywords: H. pylori; SNP (single nucleotide polymorphism); ATG7 H. pylori; SNP (single nucleotide polymorphism); ATG7

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MDPI and ACS Style

Yamaguchi, N.; Sakaguchi, T.; Taira, M.; Fukuda, D.; Ohnita, K.; Hirayama, T.; Yashima, K.; Isomoto, H.; Tsukamoto, K. Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis. J. Clin. Med. 2024, 13, 629. https://doi.org/10.3390/jcm13020629

AMA Style

Yamaguchi N, Sakaguchi T, Taira M, Fukuda D, Ohnita K, Hirayama T, Yashima K, Isomoto H, Tsukamoto K. Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis. Journal of Clinical Medicine. 2024; 13(2):629. https://doi.org/10.3390/jcm13020629

Chicago/Turabian Style

Yamaguchi, Naoyuki, Takuki Sakaguchi, Miki Taira, Daisuke Fukuda, Ken Ohnita, Tatsuro Hirayama, Kazuo Yashima, Hajime Isomoto, and Kazuhiro Tsukamoto. 2024. "Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis" Journal of Clinical Medicine 13, no. 2: 629. https://doi.org/10.3390/jcm13020629

APA Style

Yamaguchi, N., Sakaguchi, T., Taira, M., Fukuda, D., Ohnita, K., Hirayama, T., Yashima, K., Isomoto, H., & Tsukamoto, K. (2024). Autophagy-Related Gene ATG7 Polymorphism Could Potentially Serve as a Biomarker of the Progression of Atrophic Gastritis. Journal of Clinical Medicine, 13(2), 629. https://doi.org/10.3390/jcm13020629

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