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Journal of Clinical Medicine, Volume 10, Issue 20

October-2 2021 - 174 articles

Cover Story: The central nervous system (CNS) is closely related to the gastrointestinal tract, mainly through regulating its function and homeostasis. Simultaneously, the gut flora affects the CNS and plays an essential role in the pathogenesis of neurologic and neuropsychological disorders such as Parkinson’s and Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, or autism spectrum disorder. The microbiota–gut–brain axis is a bidirectional nervous, endocrine, and immune communication between these two organs. In this article, a review is presented and discussed, with a specific focus on the changes of gut microbiota, gut–brain axis, related disorders, and the factors that influence gut imbalance. View this paper
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Articles (174)

  • Article
  • Open Access
22 Citations
3,239 Views
17 Pages

Machine Learning Algorithms Provide Greater Prediction of Response to SCS Than Lead Screening Trial: A Predictive AI-Based Multicenter Study

  • Amine Ounajim,
  • Maxime Billot,
  • Lisa Goudman,
  • Pierre-Yves Louis,
  • Yousri Slaoui,
  • Manuel Roulaud,
  • Bénédicte Bouche,
  • Philippe Page,
  • Bertille Lorgeoux and
  • Sandrine Baron
  • + 8 authors

18 October 2021

Persistent pain after spinal surgery can be successfully addressed by spinal cord stimulation (SCS). International guidelines strongly recommend that a lead trial be performed before any permanent implantation. Recent clinical data highlight some maj...

  • Article
  • Open Access
7 Citations
3,494 Views
10 Pages

Characteristics of Prehospital Death in Trauma Victims

  • Jan Gewiess,
  • Christoph Emanuel Albers,
  • Hans-Christoph Pape,
  • Hannes Bangerter,
  • Wolf-Dieter Zech,
  • Marius Johann Baptist Keel and
  • Johannes Dominik Bastian

18 October 2021

Background: Using Injury Severity Score (ISS) data, this study aimed to give an overview of trauma mechanisms, causes of death, injury patterns, and potential survivability in prehospital trauma victims. Methods: Age, gender, trauma mechanism, cause...

  • Article
  • Open Access
9 Citations
3,102 Views
8 Pages

The Predictive Role of Modified Early Warning Score in 174 Hematological Patients at the Point of Transfer to the Intensive Care Unit

  • Catalin Constantinescu,
  • Sergiu Pasca,
  • Sabina Iluta,
  • Grigore Gafencu,
  • Maria Santa,
  • Ciprian Jitaru,
  • Patric Teodorescu,
  • Delia Dima,
  • Mihnea Zdrenghea and
  • Ciprian Tomuleasa

18 October 2021

Introduction: The examination of vital signs and their changes during illness can alert physicians to possible impending deterioration and organ dysfunction. The Modified Early Warning Score (MEWS) is used worldwide as a track and trigger system that...

  • Article
  • Open Access
10 Citations
2,853 Views
13 Pages

Real-World Incidence of Immune-Related Adverse Events Associated with Nivolumab Plus Ipilimumab in Patients with Advanced Renal Cell Carcinoma: A Retrospective Observational Study

  • Satoshi Washino,
  • Hideki Takeshita,
  • Masaharu Inoue,
  • Makoto Kagawa,
  • Takahiko Soma,
  • Hodaka Yamada,
  • Yukio Kageyama,
  • Tomoaki Miyagawa and
  • Satoru Kawakami

18 October 2021

Real-world incidence of immune-related adverse events (irAEs) associated with nivolumab plus ipilimumab in patients with renal cell carcinoma (RCC) has been rarely demonstrated. The present study aims to report the safety outcomes of this combination...

  • Review
  • Open Access
21 Citations
3,633 Views
19 Pages

The Person’s Care Requires a Sex and Gender Approach

  • Ilaria Campesi,
  • Andrea Montella,
  • Giuseppe Seghieri and
  • Flavia Franconi

18 October 2021

There is an urgent need to optimize pharmacology therapy with a consideration of high interindividual variability and economic costs. A sex–gender approach (which considers men, women, and people of diverse gender identities) and the assessment of di...

  • Review
  • Open Access
15 Citations
4,839 Views
11 Pages

The Role of Microbial Factors in Prostate Cancer Development—An Up-to-Date Review

  • Karolina Garbas,
  • Piotr Zapała,
  • Łukasz Zapała and
  • Piotr Radziszewski

18 October 2021

Up-to-date studies emphasize the role of human urinary and intestinal microbiome in maintaining urogenital health. Both microbial flora and sexually transmitted pathogens may affect metabolic or immune mechanisms and consequently promote or inhibit p...

  • Article
  • Open Access
19 Citations
2,837 Views
9 Pages

Incidence and Transition of Acute Kidney Injury, Acute Kidney Disease to Chronic Kidney Disease after Acute Type A Aortic Dissection Surgery

  • Chih-Hsiang Chang,
  • Shao-Wei Chen,
  • Jia-Jin Chen,
  • Yi-Hsin Chan,
  • Chieh-Li Yen,
  • Tao Han Lee and
  • Yu-Ting Cheng

18 October 2021

Acute kidney disease (AKD) is the persistence of renal injury between days 8 and 90 after an initial acute kidney injury (AKI). In this study, we aimed to explore the incidence of AKD, the association between AKD, and patient outcomes after acute typ...

  • Article
  • Open Access
1 Citations
2,112 Views
13 Pages

Influence of Pharyngeal Anaesthesia on Post-Bronchoscopic Coughing: A Prospective, Single Blinded, Multicentre Trial

  • Maik Häntschel,
  • Mariella Zahn-Paulsen,
  • Ahmed Ehab,
  • Michael Böckeler,
  • Werner Spengler,
  • Richard A. Lewis,
  • Hubert Hautmann and
  • Jürgen Hetzel

18 October 2021

Background: Local anaesthesia of the pharynx (LAP) was introduced in the era of rigid bronchoscopy (which was initially a conscious procedure under local anaesthetic), and continued into the era of flexible bronchoscopy (FB) in order to facilitate in...

  • Article
  • Open Access
18 Citations
2,759 Views
16 Pages

Comparison of Preoperative Cone-Beam Computed Tomography and 3D-Double Echo Steady-State MRI in Third Molar Surgery

  • Silvio Valdec,
  • Adib Al-Haj Husain,
  • Sebastian Winklhofer,
  • Marcel Müller,
  • Marco Piccirelli and
  • Bernd Stadlinger

18 October 2021

We investigated the reliability of assessing a positional relationship between the inferior alveolar nerve (IAN) and mandibular third molar (MTM) based on CBCT, 3D-DESS MRI, and CBCT/MRI image fusion. Furthermore, we evaluated qualitative parameters...

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J. Clin. Med. - ISSN 2077-0383