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Journal of Clinical Medicine, Volume 10, Issue 20

2021 October-2 - 174 articles

Cover Story: The central nervous system (CNS) is closely related to the gastrointestinal tract, mainly through regulating its function and homeostasis. Simultaneously, the gut flora affects the CNS and plays an essential role in the pathogenesis of neurologic and neuropsychological disorders such as Parkinson’s and Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, or autism spectrum disorder. The microbiota–gut–brain axis is a bidirectional nervous, endocrine, and immune communication between these two organs. In this article, a review is presented and discussed, with a specific focus on the changes of gut microbiota, gut–brain axis, related disorders, and the factors that influence gut imbalance. View this paper
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Articles (174)

  • Article
  • Open Access
4 Citations
4,506 Views
10 Pages

Clinical Analysis of the Diagnostic Accuracy and Time of Execution of a Transillumination Caries Detection Method Compared to Bitewing Radiographs

  • Gian Andrea Pelliccioni,
  • Maria Rosaria Antonella Gatto,
  • Silvia Bolognesi,
  • Daniele Dal Fiume,
  • Maicon Sebold and
  • Lorenzo Breschi

19 October 2021

Purposes: this clinical study evaluated the accuracy and execution time of a digital imaging fiber-optic transillumination (DIFOTI) technique for the detection of approximal caries in posterior teeth compared to intra-oral examination associated with...

  • Article
  • Open Access
4 Citations
2,297 Views
11 Pages

Retinopathy of Prematurity and Hearing Impairment in Infants Born with Very-Low-Birth-Weight: Analysis of a Korean Neonatal Network Database

  • Chang Myeon Song,
  • Ja-Hye Ahn,
  • Jae Kyoon Hwang,
  • Chang-Ryul Kim,
  • Mi Jung Kim,
  • Kyeong Mi Lee,
  • Hyun Ju Lee and
  • Seong Joon Ahn

19 October 2021

Background: To investigate hearing impairment and its association with retinopathy of prematurity (ROP) among children born with very low birth weight (VLBW, birth weight < 1500 g). Methods: This prospective registry study included 7940 VLBW infan...

  • Review
  • Open Access
15 Citations
4,341 Views
20 Pages

Heart Failure in Patients with Arrhythmogenic Cardiomyopathy

  • Shi Chen,
  • Liang Chen,
  • Firat Duru and
  • Shengshou Hu

19 October 2021

Arrhythmogenic cardiomyopathy (ACM) is a rare inherited cardiomyopathy characterized as fibro-fatty replacement, and a common cause for sudden cardiac death in young athletes. Development of heart failure (HF) has been an under-recognized complicatio...

  • Review
  • Open Access
29 Citations
6,453 Views
13 Pages

Fertility-Sparing Treatment of Patients with Endometrial Cancer: A Review of the Literature

  • Umberto Leone Roberti Maggiore,
  • Rola Khamisy-Farah,
  • Nicola Luigi Bragazzi,
  • Giorgio Bogani,
  • Fabio Martinelli,
  • Salvatore Lopez,
  • Valentina Chiappa,
  • Mauro Signorelli,
  • Antonino Ditto and
  • Francesco Raspagliesi

19 October 2021

Endometrial cancer (EC) is currently the most common malignancy of the female genital tract in developed countries. Although it is more common in postmenopausal women, it may affect up to 25% in the premenopausal age and 3–5% under the age of 40 year...

  • Article
  • Open Access
24 Citations
5,331 Views
15 Pages

Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients—Insights from the PRoVENT-COVID Observational Study

  • Willemke Stilma,
  • David M. P. van Meenen,
  • Christel M. A. Valk,
  • Hendrik de Bruin,
  • Frederique Paulus,
  • Ary Serpa Neto,
  • Marcus J. Schultz and
  • on behalf of the PRoVENT-COVID Collaborative Group

19 October 2021

We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (CO...

  • Review
  • Open Access
11 Citations
3,644 Views
24 Pages

Shared Care and Virtual Clinics for Glaucoma in a Hospital Setting

  • Anne-Sophie Simons,
  • Julie Vercauteren,
  • João Barbosa-Breda and
  • Ingeborg Stalmans

19 October 2021

Glaucoma patients require lifelong management, and the prevalence of glaucoma is expected to increase, resulting in capacity problems in many hospital eye departments. New models of care delivery are needed to offer requisite capacity. This review ev...

  • Review
  • Open Access
105 Citations
18,911 Views
22 Pages

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview

  • Undine-Sophie Deumer,
  • Angelica Varesi,
  • Valentina Floris,
  • Gabriele Savioli,
  • Elisa Mantovani,
  • Paulina López-Carrasco,
  • Gian Marco Rosati,
  • Sakshi Prasad and
  • Giovanni Ricevuti

19 October 2021

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as “brain fog”. These symptoms often pr...

  • Article
  • Open Access
6 Citations
2,699 Views
12 Pages

Minimally Invasive Surgery and Surgical Volume-Specific Survival and Perioperative Outcome: Unmet Need for Evidence in Gynecologic Malignancy

  • Shinya Matsuzaki,
  • Maximilian Klar,
  • Erica J. Chang,
  • Satoko Matsuzaki,
  • Michihide Maeda,
  • Renee H. Zhang,
  • Lynda D. Roman and
  • Koji Matsuo

19 October 2021

This study examined the effect of hospital surgical volume on oncologic outcomes in minimally invasive surgery (MIS) for gynecologic malignancies. The objectives were to assess survival outcomes related to hospital surgical volume and to evaluate per...

  • Article
  • Open Access
4 Citations
2,711 Views
14 Pages

19 October 2021

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of multiple autoantibodies, resulting in tissue and organ damage. Recent studies have revealed that interleukin-23 (IL-23) and interleukin-27...

  • Review
  • Open Access
4 Citations
3,138 Views
12 Pages

19 October 2021

Background: SARS-CoV-2 has significantly transformed the healthcare environment, and it has triggered the development of electronic health and artificial intelligence mechanisms, for instance. In this overview, we concentrated on enhancing the two co...

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J. Clin. Med. - ISSN 2077-0383