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Vaccines, Volume 9, Issue 3

2021 March - 117 articles

Cover Story: A safe and effective preventative or therapeutic vaccine for herpes simplex virus 2 (HSV-2) has eluded development for decades. Live-attenuated HSV-2 vaccines are attractive alternatives to previous vaccine candidates. We assessed the safety of two novel live-attenuated HSV-2 vaccine candidates, RVx201 and RVx202. Guinea pigs were inoculated vaginally or intradermally with RVx201, RvX202 (107 PFU each) or wild-type virus (105 PFU) and observed for 28 days. All animals inoculated with RVx201 or RVx202 survived. The vaccine candidates did not cause disease, did not establish latency, and elicited a neutralizing antibody response against HSV-2. Based on these results, further efficacy testing of these vaccine candidates as preventative and/or therapeutic anti-HSV-2 vaccines is merited. View this paper.
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Vaccines - ISSN 2076-393X
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