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Vaccines, Volume 9, Issue 10
October 2021 - 160 articles
Cover Story: Understanding the molecular mechanisms of viral infection is critical for the development of antiviral drugs and vaccines. This paper dissects the mechanism of action of the HSV-1 ICP22 protein in downregulating host cell gene expression and activation of HSV-1 gene transcription. ICP22 inhibits the host cell elongation and pol II CTD Ser2 kinase CDK9 to downregulate host cell gene transcription. Pull-down assays and site-specific incorporation of a photoreactive amino acid coupled with affinity purification-mass spectrometry indicate that ICP22 also sequesters several additional critical host cell elongation regulators, including the FACT complex and CDK12. Our model proposes that the tegument protein VP16 can then seize these elongation factors from ICP22 for viral gene transcription to promote HSV-1 pathogenesis. View this paper
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Vaccines - ISSN 2076-393XCreative Common CC BY license