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Vaccines, Volume 11, Issue 1
January 2023 - 196 articles
Cover Story: Bovine respiratory syncytial virus (BRSV) is one of the major pathogens involved in respiratory disease of young calves. Maternal BRSV humoral immunity is considered one potential strategy to protect calves in the first months of life. We showed that the vaccination of cows with a killed BRSV vaccine just before the last month of gestation provides a strong antibody response in animals and high quantities of BRSV-neutralizing antibodies in the colostrum. Calves fed colostrum from vaccinated cows were clinically protected against a BRSV challenge at 21 days of age. This supports the dam BRSV vaccination as a complementary approach to protect calves early in life against this severe disease. However, the detection of BRSV in the nasal cavities of challenged calves suggests no benefit of dam vaccination on virus circulation between calves. View this paper
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Vaccines - ISSN 2076-393XCreative Common CC BY license