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Antioxidants, Volume 13, Issue 1

January 2024 - 134 articles

Cover Story: Heavy metals pose a serious threat to human health. Recent studies have linked damage associated with heavy metal exposure to oxidative stress and aging, and have identified common pathways, such as apoptosis, endoplasmic reticulum stress, and mitochondrial stress. Chelation therapy is a traditional approach to heavy metal-induced disorders, but recently the focus has shifted to antioxidants, which have been proven to be more effective treatments. This review discusses the molecular basis of heavy metal toxicity, its correlation with aging, and its clinical significance, as well as the role of antioxidants and other protective agents against heavy metal damage, reflecting the evolving paradigm in therapeutic approaches. View this paper
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Articles (134)

  • Article
  • Open Access
8 Citations
3,110 Views
22 Pages

17 January 2024

Cadmium (Cd) is a major health concern globally and can accumulate and cause damage in the liver for which there is no approved treatment. Baicalin and N-acetylcysteine (NAC) have been found to have protective effects against a variety of liver injur...

  • Article
  • Open Access
8 Citations
3,860 Views
18 Pages

Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity

  • Sibren Haesen,
  • Manon Marie Jager,
  • Aline Brillouet,
  • Iris de Laat,
  • Lotte Vastmans,
  • Eline Verghote,
  • Anouk Delaet,
  • Sarah D’Haese,
  • Ibrahim Hamad and
  • Markus Kleinewietfeld
  • + 6 authors

17 January 2024

The use of doxorubicin (DOX) chemotherapy is restricted due to dose-dependent cardiotoxicity. Pyridoxamine (PM) is a vitamin B6 derivative with favorable effects on diverse cardiovascular diseases, suggesting a cardioprotective effect on DOX-induced...

  • Article
  • Open Access
4 Citations
3,374 Views
14 Pages

Effects of Particulate Matter Inhalation during Exercise on Oxidative Stress and Mitochondrial Function in Mouse Skeletal Muscle

  • Jinhan Park,
  • Junho Jang,
  • Byunghun So,
  • Kanggyu Lee,
  • Dongjin Yeom,
  • Ziyi Zhang,
  • Woo Shik Shin and
  • Chounghun Kang

17 January 2024

Particulate matter (PM) has deleterious consequences not only on the respiratory system but also on essential human organs, such as the heart, blood vessels, kidneys, and liver. However, the effects of PM inhalation on skeletal muscles have yet to be...

  • Article
  • Open Access
6 Citations
2,804 Views
17 Pages

Chemical Profiling, Antioxidant, and Anti-Inflammatory Activities of Hyoseris radiata L., a Plant Used in the Phytoalimurgic Tradition

  • Maria Vitiello,
  • Michela Pecoraro,
  • Marinella De Leo,
  • Fabiano Camangi,
  • Valentina Parisi,
  • Giuliana Donadio,
  • Alessandra Braca,
  • Silvia Franceschelli and
  • Nunziatina De Tommasi

17 January 2024

Hyoseris radiata L. (Asteraceae), known as “wild chicory”, is a perennial herbaceous plant native to the Mediterranean region, North Africa, and West Asia. Collected from the wild, the plant is largely used in Italy for culinary purposes...

  • Article
  • Open Access
3 Citations
2,067 Views
15 Pages

Association between Oxidative Stress with Psychological and Biochemical Variables in a Sample of Healthy Mexican People: A Cross-Sectional Study

  • Ana Míriam Saldaña-Cruz,
  • Sergio Gabriel Gallardo-Moya,
  • Liliana Campos-Medina and
  • Aniel Jessica Leticia Brambila-Tapia

17 January 2024

Oxidative stress (OS) has been linked to cell damage and chronic disease development; however, the study of psychological factors related with OS has been limited, as has its relationship with biochemical and personal variables. Therefore, the aim of...

  • Article
  • Open Access
3 Citations
3,483 Views
18 Pages

Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts

  • Jin-Woong Heo,
  • Hye-Eun Lee,
  • Jimin Lee,
  • Leo Sungwong Choi,
  • Jaejin Shin,
  • Ji-Young Mun,
  • Hyung-Soon Park,
  • Sang-Chul Park and
  • Chang-Hoon Nam

16 January 2024

The process of cellular senescence, which is characterized by stable cell cycle arrest, is strongly associated with dysfunctional cellular metabolism and circadian rhythmicity, both of which are reported to result from and also be causal to cellular...

  • Article
  • Open Access
8 Citations
3,044 Views
16 Pages

Albumin Redox Modifications Promote Cell Calcification Reflecting the Impact of Oxidative Status on Aortic Valve Disease and Atherosclerosis

  • Tamara Sastre-Oliva,
  • Nerea Corbacho-Alonso,
  • Elena Rodriguez-Sanchez,
  • Elisa Mercado-García,
  • Ines Perales-Sanchez,
  • German Hernandez-Fernandez,
  • Cristina Juarez-Alia,
  • Teresa Tejerina,
  • Luis F. López-Almodóvar and
  • Luis R. Padial
  • + 6 authors

16 January 2024

Calcific aortic valve disease (CAVD) and coronary artery disease (CAD) are related cardiovascular diseases in which common mechanisms lead to tissue calcification. Oxidative stress plays a key role in these diseases and there is also evidence that th...

  • Article
  • Open Access
7 Citations
3,053 Views
14 Pages

16 January 2024

The oxidative balance score (OBS) is a novel composite of pro- and anti-oxidative markers for assessing the risk of cardiometabolic diseases and non-alcoholic fatty liver disease (NAFLD). However, it has not yet been established whether the OBS is re...

  • Article
  • Open Access
3 Citations
3,246 Views
24 Pages

Oxidative Post-translational Protein Modifications upon Ischemia/Reperfusion Injury

  • Aleksandra Binek,
  • Celia Castans,
  • Inmaculada Jorge,
  • Navratan Bagwan,
  • José Manuel Rodríguez,
  • Rodrigo Fernández-Jiménez,
  • Carlos Galán-Arriola,
  • Eduardo Oliver,
  • Mónica Gómez and
  • Agustín Clemente-Moragón
  • + 3 authors

16 January 2024

While reperfusion, or restoration of coronary blood flow in acute myocardial infarction, is a requisite for myocardial salvage, it can paradoxically induce a specific damage known as ischemia/reperfusion (I/R) injury. Our understanding of the precise...

  • Article
  • Open Access
12 Citations
4,030 Views
14 Pages

Anti-Aging Properties of Chitosan-Based Hydrogels Rich in Bilberry Fruit Extract

  • Elżbieta Studzińska-Sroka,
  • Magdalena Paczkowska-Walendowska,
  • Cansu Erdem,
  • Jarosław Paluszczak,
  • Robert Kleszcz,
  • Marta Hoszman-Kulisz and
  • Judyta Cielecka-Piontek

15 January 2024

Photoaging is a process related to an increased level of reactive oxygen species (ROS). Polyphenols can scavenge free radicals in the body, which can delay skin aging. Therefore, our work aimed to prepare a biologically active extract from dry fruits...

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Antioxidants - ISSN 2076-3921