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Antioxidants, Volume 12, Issue 8

2023 August - 172 articles

Cover Story: This review heads a Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx). Among its critical roles, GSH serves as a co-substrate for the formation and breakdown of protein mixed disulfides (protein-SSG). This posttranslational modification regulated by Grx acts as a switch, interconverting inactive and active forms of proteins and mediating redox signal transduction and thiol homeostasis. Dysregulation of this system is implicated in various diseases involving oxidative stress. The ten articles in this Special Issue provide current insights into the GSH/Grx system, including potential clinical applications; for example, elevating Grx could be an anti-fibrotic therapy, and mimicking S-glutathionylation could inhibit dimerization of the key proteases of the HIV and SARS-CoV-2 viruses. View this paper
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Articles (172)

  • Review
  • Open Access
44 Citations
9,092 Views
19 Pages

A Critical Review of Kaempferol in Intestinal Health and Diseases

  • Jun Chen,
  • Haopeng Zhong,
  • Zhouyin Huang,
  • Xingping Chen,
  • Jinming You and
  • Tiande Zou

20 August 2023

Kaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid displaying significant potential in various biological activities. The chemical structure of kaempferol is distinguished by the presence of phenyl rings and four h...

  • Article
  • Open Access
9 Citations
3,810 Views
24 Pages

Comprehensive Comparison of Effects of Antioxidant (Astaxanthin) Supplementation from Different Sources in Haliotis discus hannai Diet

  • Weiguang Zou,
  • Jiawei Hong,
  • Wenchao Yu,
  • Yaobin Ma,
  • Jiacheng Gan,
  • Yanbo Liu,
  • Xuan Luo,
  • Weiwei You and
  • Caihuan Ke

19 August 2023

Dietary antioxidant supplementation, especially astaxanthin, has shown great results on reproductive aspects, egg quality, growth, survival, immunity, stress tolerance, and disease resistance in aquatic animals. However, the effects of dietary astaxa...

  • Article
  • Open Access
10 Citations
2,664 Views
23 Pages

Insight into Physiological and Biochemical Determinants of Salt Stress Tolerance in Tetraploid Citrus

  • Marie Bonnin,
  • Bénédicte Favreau,
  • Alexandre Soriano,
  • Nathalie Leonhardt,
  • Julie Oustric,
  • Radia Lourkisti,
  • Patrick Ollitrault,
  • Raphaël Morillon,
  • Liliane Berti and
  • Jérémie Santini

19 August 2023

Citrus are classified as salt-sensitive crops. However, a large diversity has been observed regarding the trends of tolerance among citrus. In the present article, physiological and biochemical studies of salt stress tolerance were carried out accord...

  • Article
  • Open Access
4 Citations
2,893 Views
17 Pages

Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis

  • Judith Cantó-Santos,
  • Laura Valls-Roca,
  • Ester Tobías,
  • Clara Oliva,
  • Francesc Josep García-García,
  • Mariona Guitart-Mampel,
  • Félix Andújar-Sánchez,
  • Anna Esteve-Codina,
  • Beatriz Martín-Mur and
  • Glòria Garrabou
  • + 6 authors

19 August 2023

Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50. It is diagnosed based on clinical and histological findings in muscle related to inflammation, degene...

  • Article
  • Open Access
32 Citations
5,434 Views
17 Pages

Exploring the Relationship between Antioxidant Enzymes, Oxidative Stress Markers, and Clinical Profile in Relapsing–Remitting Multiple Sclerosis

  • Anna Bizoń,
  • Justyna Chojdak-Łukasiewicz,
  • Sławomir Budrewicz,
  • Anna Pokryszko-Dragan and
  • Agnieszka Piwowar

19 August 2023

We aimed to investigate the extent of alterations in the pro/antioxidant balance in the blood of patients with relapsing–remitting multiple sclerosis (RRMS) in relation to drug-modified therapy, gender, disability score, and disease duration. 1...

  • Article
  • Open Access
10 Citations
2,034 Views
13 Pages

Technologically Driven Approaches for the Integrative Use of Wild Blackthorn (Prunus spinosa L.) Fruits in Foods and Nutraceuticals

  • Oana Viorela Nistor,
  • Ștefania Adelina Milea,
  • Bogdan Păcularu-Burada,
  • Doina Georgeta Andronoiu,
  • Gabriela Râpeanu and
  • Nicoleta Stănciuc

19 August 2023

Different technological approaches were used in this study for the valorization of blackthorn (Prunus spinosa L.) fruits in marmalade, jam, jelly, and nutraceuticals. Marmalade showed the highest concentrations of polyphenols (7.61 ± 0.05 mg g...

  • Article
  • Open Access
10 Citations
3,131 Views
15 Pages

Development and Characterization of Inula britannica Extract-Loaded Liposomes: Potential as Anti-Inflammatory Functional Food Ingredients

  • Chi Rac Hong,
  • Eun Ha Lee,
  • Young Hoon Jung,
  • Ju-Hoon Lee,
  • Hyun-Dong Paik,
  • Sung-Chul Hong and
  • Seung Jun Choi

18 August 2023

We investigated the potential of Inula britannica extract encapsulated in liposomes as a functional food ingredient with enhanced bioavailability and stability. Inula britannica, known for its anti-inflammatory properties and various health benefits,...

  • Article
  • Open Access
18 Citations
3,252 Views
26 Pages

SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS

  • Federica Barreca,
  • Michele Aventaggiato,
  • Laura Vitiello,
  • Luigi Sansone,
  • Matteo Antonio Russo,
  • Antonello Mai,
  • Sergio Valente and
  • Marco Tafani

18 August 2023

Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that...

  • Article
  • Open Access
9 Citations
3,541 Views
26 Pages

18 August 2023

Dysregulation of vitamin D receptor (VDR) is implicated in chronic obstructive pulmonary disease. However, whether VDR dysregulation contributes to the development of pulmonary fibrosis remains largely unknown. Analysis of bulk and single-cell RNA pr...

  • Article
  • Open Access
21 Citations
4,014 Views
20 Pages

Phytochemical Constituents and Biological Activity of Wild and Cultivated Rosmarinus officinalis Hydroalcoholic Extracts

  • Rosaria Francolino,
  • Mara Martino,
  • Lucia Caputo,
  • Giuseppe Amato,
  • Giuseppina Chianese,
  • Ernesto Gargiulo,
  • Carmen Formisano,
  • Benedetta Romano,
  • Giuseppe Ercolano and
  • Vincenzo De Feo
  • + 2 authors

18 August 2023

Rosmarinus officinalis L. is an aromatic evergreen plant from the Lamiaceae family. The purpose of this study was to compare the chemical profile and bioactivities of hydroalcoholic extracts derived from wild and cultivated R. officinalis. The chemic...

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Antioxidants - ISSN 2076-3921