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Antioxidants, Volume 12, Issue 1

January 2023 - 211 articles

Cover Story: Oxidative cell damage is one of the common features of cancer and Alzheimer’s disease (AD), and Se-containing molecules have demonstrated preventive effects against both diseases. In this work, we characterized a molecule (14a) with dual cytotoxic and acetylcholinesterase inhibitory (AChEI) activity. The structure of this molecule combines aspirin with a functional group commonly present in garlic through a selenoester bond. It demonstrated potent antiproliferative activity against the most resistant cancer cell lines of the NCI-60 panel. It also exhibited slightly greater AChE inhibition than galantamine along with a 3-fold higher in vitro BBB permeation. Molecular dynamics simulations supported AChEI results. Thus, 14a may represent a promising candidate to treat both cancer and AD. View this paper
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Articles (211)

  • Article
  • Open Access
42 Citations
3,905 Views
16 Pages

Dihydromyricetin Attenuates Diabetic Cardiomyopathy by Inhibiting Oxidative Stress, Inflammation and Necroptosis via Sirtuin 3 Activation

  • Yun Chen,
  • Yangyang Zheng,
  • Ruixiang Chen,
  • Jieru Shen,
  • Shuping Zhang,
  • Yunhui Gu,
  • Jiahai Shi and
  • Guoliang Meng

15 January 2023

Dihydromyricetin (DHY), the main flavonoid component in Ampelopsis grossedentata, has important benefits for health. The present study aimed to investigate the exact effects and possible mechanisms of DHY on diabetic cardiomyopathy (DCM). Male C57BL/...

  • Article
  • Open Access
15 Citations
4,009 Views
21 Pages

15 January 2023

To meet the demand for chicken meat production, new additives that promote growth and health without adverse effects on meat quality are being investigated. This study was conducted to investigate the effect of protected sodium butyrate (PSB) (0 vs....

  • Article
  • Open Access
11 Citations
4,917 Views
14 Pages

Obesity Affects Maternal and Neonatal HDL Metabolism and Function

  • Julia T. Stadler,
  • Mireille N. M. van Poppel,
  • Christian Wadsack,
  • Michael Holzer,
  • Anja Pammer,
  • David Simmons,
  • David Hill,
  • Gernot Desoye,
  • Gunther Marsche and
  • DALI Core Investigator Group

14 January 2023

Pregravid obesity is one of the major risk factors for pregnancy complications such as gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in children of affected mothers. However, the biological mechanisms that underpi...

  • Article
  • Open Access
19 Citations
3,897 Views
17 Pages

Oleuropein Attenuates Oxidative Stress in Human Trophoblast Cells

  • Andrea Pirković,
  • Aleksandra Vilotić,
  • Sunčica Borozan,
  • Mirjana Nacka-Aleksić,
  • Žanka Bojić-Trbojević,
  • Milica Jovanović Krivokuća,
  • Maurizio Battino,
  • Francesca Giampieri and
  • Dragana Dekanski

14 January 2023

Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells in vitro, by examining the changes in several markers implicated in oxidative stress interactions in the placenta. Tropho...

  • Article
  • Open Access
21 Citations
3,289 Views
15 Pages

14 January 2023

The rise in water temperature caused by global warming is seriously threatening the development of aquatic animals. However, the physiological response mechanism behind the adverse effects of thermal conditions on L. capito remains unclear. In this s...

  • Review
  • Open Access
8 Citations
4,297 Views
18 Pages

Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies

  • Ashley K. Putman,
  • G. Andres Contreras and
  • Emilio P. Mottillo

14 January 2023

Metabolic diseases, such as diabetes and non-alcoholic fatty liver disease (NAFLD), have several negative health outcomes on affected humans. Dysregulated energy metabolism is a key component underlying the pathophysiology of these conditions. Adipos...

  • Review
  • Open Access
21 Citations
5,504 Views
15 Pages

Oxidative Stress and Antioxidants in Chronic Rhinosinusitis with Nasal Polyps

  • Junhu Tai,
  • Jae-Min Shin,
  • Jaehyung Park,
  • Munsoo Han and
  • Tae Hoon Kim

14 January 2023

Oxidative stress results from an imbalance between the production of reactive oxygen species and the body’s antioxidant defense system. It plays an important role in the regulation of the immune response and can be a pathogenic factor in variou...

  • Article
  • Open Access
27 Citations
3,675 Views
13 Pages

13 January 2023

Acute liver injury is a type of liver diseases, and it has raised concerns worldwide due to the lack of effective therapies. The aim of this study is to investigate the protective effects of nootkatone (NOOT) on carbon tetrachloride (CCl4)-caused acu...

  • Article
  • Open Access
10 Citations
3,866 Views
19 Pages

13 January 2023

Thiol antioxidants play important roles in cell and body defense against oxidative stress. In body fluid, albumin is the richest source of thiol antioxidants. One recent study showed that the reductive modification of thiol residues in albumin potent...

  • Article
  • Open Access
6 Citations
2,879 Views
15 Pages

Effect of Encapsulation Material on Lipid Bioaccessibility and Oxidation during In Vitro Digestion of Black Seed Oil

  • Jon Alberdi-Cedeño,
  • Martha Aichner,
  • Agnes Mistlberger-Reiner,
  • Aimin Shi and
  • Marc Pignitter

13 January 2023

Different encapsulation materials might not only affect lipid hydrolysis but also lipid oxidation during in vitro digestion. Thus, this study aimed to investigate the effect of two commonly used shell materials, starch and gelatin, on the extent of l...

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Antioxidants - ISSN 2076-3921