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Antioxidants, Volume 12, Issue 1

January 2023 - 211 articles

Cover Story: Oxidative cell damage is one of the common features of cancer and Alzheimer’s disease (AD), and Se-containing molecules have demonstrated preventive effects against both diseases. In this work, we characterized a molecule (14a) with dual cytotoxic and acetylcholinesterase inhibitory (AChEI) activity. The structure of this molecule combines aspirin with a functional group commonly present in garlic through a selenoester bond. It demonstrated potent antiproliferative activity against the most resistant cancer cell lines of the NCI-60 panel. It also exhibited slightly greater AChE inhibition than galantamine along with a 3-fold higher in vitro BBB permeation. Molecular dynamics simulations supported AChEI results. Thus, 14a may represent a promising candidate to treat both cancer and AD. View this paper
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Articles (211)

  • Article
  • Open Access
33 Citations
5,539 Views
15 Pages

Postharvest Treatment with Abscisic Acid Alleviates Chilling Injury in Zucchini Fruit by Regulating Phenolic Metabolism and Non-Enzymatic Antioxidant System

  • Alejandro Castro-Cegrí,
  • Sandra Sierra,
  • Laura Hidalgo-Santiago,
  • Adelaida Esteban-Muñoz,
  • Manuel Jamilena,
  • Dolores Garrido and
  • Francisco Palma

16 January 2023

Reports show that phytohormone abscisic acid (ABA) is involved in reducing zucchini postharvest chilling injury. During the storage of harvested fruit at low temperatures, chilling injury symptoms were associated with cell damage through the producti...

  • Article
  • Open Access
17 Citations
4,013 Views
20 Pages

Post-Distillation By-Products of Aromatic Plants from Lamiaceae Family as Rich Sources of Antioxidants and Enzyme Inhibitors

  • Simon Vlad Luca,
  • Gokhan Zengin,
  • Kouadio Ibrahime Sinan,
  • Krystyna Skalicka-Woźniak and
  • Adriana Trifan

16 January 2023

There is currently no use for the vast quantities of post-distillation by-products, such as spent plant materials and residual waters, produced by the essential oil (EO) industry of aromatic herbs. In this study, the EOs of three Lamiaceae species (t...

  • Article
  • Open Access
16 Citations
3,496 Views
19 Pages

Dietary Methionine Level Impacts the Growth, Nutrient Metabolism, Antioxidant Capacity and Immunity of the Chinese Mitten Crab (Eriocheir sinensis) under Chronic Heat Stress

  • Jiadai Liu,
  • Cong Zhang,
  • Xiaodan Wang,
  • Xinyu Li,
  • Qincheng Huang,
  • Han Wang,
  • Yixin Miao,
  • Erchao Li,
  • Jianguang Qin and
  • Liqiao Chen

16 January 2023

This study examined whether diets with high dietary methionine levels could alleviate chronic heat stress in Chinese mitten crab Eriocheir sinensis. Crabs were fed three dietary methionine levels of 0.49%, 1.29% and 2.09% for six weeks. The analyzed...

  • Article
  • Open Access
7 Citations
4,383 Views
12 Pages

Facile Fabrication of α-Bisabolol Nanoparticles with Improved Antioxidant and Antibacterial Effects

  • Sangwoo Kim,
  • Sohyeon Yu,
  • Jisu Kim,
  • Nisar Ul Khaliq,
  • Won Il Choi,
  • Hyungjun Kim and
  • Daekyung Sung

16 January 2023

Bioactive compounds are widely used in the bio-industry because of their antioxidant and antibacterial activities. Because of excessive oxidative stress, which causes various diseases in humans, and because preservatives used in bioproducts cause all...

  • Article
  • Open Access
17 Citations
3,578 Views
14 Pages

Effects of Dietary Supplementation of Pomegranate Peel with Xylanase on Egg Quality and Antioxidant Parameters in Laying Hens

  • Styliani Lioliopoulou,
  • Georgios A. Papadopoulos,
  • Ilias Giannenas,
  • Konstantina Vasilopoulou,
  • Clare Squires,
  • Paschalis Fortomaris and
  • Fani Th. Mantzouridou

16 January 2023

Pomegranate contains bioactive compounds in all its parts. In this study, two levels of pomegranate peel byproduct (PPB) with or without the inclusion of xylanase enzyme were used to supplement laying hens’ diet, in a 2 × 2 full factorial...

  • Article
  • Open Access
12 Citations
3,749 Views
15 Pages

16 January 2023

Dietary flavones 6,3´,4´-trihydroxyflavone (6,3´,4´-HOFL) and 7,3´,4´-trihydroxyflavone (7,3´,4´-HOFL) showed preliminary antioxidant and anti-inflammatory activities in a two-dimensional (2D) cell cult...

  • Article
  • Open Access
3 Citations
3,727 Views
11 Pages

Effect of Ascosphaera apis Infestation on the Activities of Four Antioxidant Enzymes in Asian Honey Bee Larval Guts

  • Kaiyao Zhang,
  • Zhongmin Fu,
  • Xiaoxue Fan,
  • Zixin Wang,
  • Siyi Wang,
  • Sijia Guo,
  • Xuze Gao,
  • Haodong Zhao,
  • Xin Jing and
  • Peiyuan Zou
  • + 4 authors

16 January 2023

Ascosphaera apis infects exclusively bee larvae and causes chalkbrood, a lethal fungal disease that results in a sharp reduction in adult bees and colony productivity. However, little is known about the effect of A. apis infestation on the activities...

  • Article
  • Open Access
13 Citations
3,493 Views
22 Pages

16 January 2023

Sustainability, becoming essential for food processing and technology, sets goals for the characterization of resources considered as food waste. In this work, information about the GC-MS metabolites of peach peels was provided as a tool that can she...

  • Review
  • Open Access
74 Citations
7,103 Views
28 Pages

15 January 2023

Insoluble-bound phenolics (IBPs) are extensively found in the cell wall and distributed in various tissues/organs of plants, mainly cereals, legumes, and pulses. In particular, IBPs are mainly distributed in the protective tissues, such as seed coat,...

  • Article
  • Open Access
20 Citations
4,124 Views
16 Pages

Potential Antioxidative Activity of Homocysteine in Erythrocytes under Oxidative Stress

  • Mingxin Ye,
  • Hui Li,
  • Hongjun Luo,
  • Yongyin Zhou,
  • Wenhong Luo and
  • Zhexuan Lin

15 January 2023

Homocysteine is an amino acid containing a free sulfhydryl group, making it probably contribute to the antioxidative capacity in the body. We recently found that plasma total homocysteine (total-Hcy) concentration increased with time when whole blood...

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Antioxidants - ISSN 2076-3921