You are currently viewing a new version of our website. To view the old version click .

Antioxidants, Volume 10, Issue 4

April 2021 - 129 articles

Cover Story: Increasingly, the fetal origins hypothesis has been implicated in the development of adult hypertension. Maternal stress and, thus, fetal glucocorticoid exposure have emerged as a central regulator in the programming of adult disease, including alterations in catecholamine biosynthesis, which leads to adult hypertension. Supplementation of maternal drinking water with antioxidants, such as EGCG or TEMPOL, throughout gestation attenuated glucocorticoid-induced alterations in catecholamine biosynthesis and the hypertensive phenotype. Furthermore, programmed changes in oxidative stress enzymes, such as Noxa1 and SOD1, as well as the epigenetic regulator HDAC7 were attenuated. How these in utero insults ultimately manifest in altered gene expression is unknown; however, increasing evidence links oxidative stress and epigenetics in the fetal programming of hypertension. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (129)

  • Article
  • Open Access
33 Citations
7,780 Views
20 Pages

The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions

  • Loes van Dam,
  • Marc Pagès-Gallego,
  • Paulien E. Polderman,
  • Robert M. van Es,
  • Boudewijn M. T. Burgering,
  • Harmjan R. Vos and
  • Tobias B. Dansen

Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger. However, H2O2 actually reacts poorly with most cysteine thiols and it is not clear how H2O...

  • Article
  • Open Access
25 Citations
5,576 Views
16 Pages

LC-ESI/MS-Phytochemical Profiling with Antioxidant, Antibacterial, Antifungal, Antiviral and In Silico Pharmacological Properties of Algerian Asphodelus tenuifolius (Cav.) Organic Extracts

  • Ayoub Khalfaoui,
  • Emira Noumi,
  • Soumia Belaabed,
  • Kaïss Aouadi,
  • Bouslama Lamjed,
  • Mohd Adnan,
  • Andrea Defant,
  • Adel Kadri,
  • Mejdi Snoussi and
  • Mushtaq Ahmad Khan
  • + 1 author

Asphodelus tenuifolius Cav. (A. tenuifolius) is a medicinal plant with a long history of traditional use to treat ailments. In this study, total phenolic and flavonoid content evaluation using LC-ESI/MS analysis and various biological activities (ant...

  • Article
  • Open Access
17 Citations
4,313 Views
17 Pages

Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3β Pathway

  • Joon-Ha Park,
  • Tae-Kyeong Lee,
  • Dae-Won Kim,
  • Hyejin Sim,
  • Jae-Chul Lee,
  • Jong-Dai Kim,
  • Ji-Hyeon Ahn,
  • Choong-Hyun Lee,
  • Young-Myeong Kim and
  • Moo-Ho Won
  • + 1 author

Salicin is a major natural compound of willow bark and displays diverse beneficial biological properties, such as antioxidant activity. However, little information available for the neuroprotective potential of salicin against ischemic brain injury h...

  • Article
  • Open Access
8 Citations
3,835 Views
16 Pages

Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats

  • Margarita R. Ramis,
  • Fiorella Sarubbo,
  • David Moranta,
  • Silvia Tejada,
  • Jerònia Lladó,
  • Antoni Miralles and
  • Susana Esteban

A healthy aging process is a requirement for good life quality. A relationship between physical activity, the consumption of antioxidants and brain health has been stablished via the activation of pathways that reduce the harmful effects of oxidative...

  • Review
  • Open Access
33 Citations
7,306 Views
19 Pages

Adipose tissue (AT) storage capacity is central in the maintenance of whole-body homeostasis, especially in obesity states. However, sustained nutrients overflow may dysregulate this function resulting in adipocytes hypertrophy, AT hypoxia, inflammat...

  • Article
  • Open Access
13 Citations
7,473 Views
13 Pages

Glycerol Improves Intracerebral Hemorrhagic Brain Injury and Associated Kidney Dysfunction in Rats

  • Cheng-Yi Chang,
  • Ping-Ho Pan,
  • Jian-Ri Li,
  • Yen-Chuan Ou,
  • Su-Lan Liao,
  • Wen-Ying Chen,
  • Yu-Hsiang Kuan and
  • Chun-Jung Chen

In stroke patients, the development of acute kidney injury (AKI) is closely linked with worse outcomes and increased mortality. In this study, the interplay between post-stroke and AKI and treatment options was investigated in a rodent model of hemor...

  • Feature Paper
  • Article
  • Open Access
23 Citations
5,375 Views
28 Pages

Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress

  • Vessela D. Kancheva,
  • Maria Antonietta Dettori,
  • Davide Fabbri,
  • Petko Alov,
  • Silvia E. Angelova,
  • Adriana K. Slavova-Kazakova,
  • Paola Carta,
  • Valerii A. Menshov,
  • Olga I. Yablonskaya and
  • Aleksei V. Trofimov
  • + 2 authors

Oxidative stress is associated with the increased production of reactive oxygen species or with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic defense. The penetration of oxygen and free radicals in the hydrophobi...

  • Article
  • Open Access
28 Citations
5,150 Views
19 Pages

Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis

  • Maria Teresa Bayo Jimenez,
  • Katie Frenis,
  • Swenja Kröller-Schön,
  • Marin Kuntic,
  • Paul Stamm,
  • Miroslava Kvandová,
  • Matthias Oelze,
  • Huige Li,
  • Sebastian Steven and
  • Thomas Münzel
  • + 1 author

Vascular oxidative stress, inflammation, and subsequent endothelial dysfunction are consequences of traditional cardiovascular risk factors, all of which contribute to cardiovascular disease. Environmental stressors, such as traffic noise and air pol...

  • Article
  • Open Access
32 Citations
5,355 Views
19 Pages

Free radical-induced oxidative stress is the root cause of many diseases, such as diabetes, stress and cardiovascular diseases. The objective of this research was to screen GABA levels, antioxidant activities and bioactive compounds in brown rice. In...

  • Feature Paper
  • Review
  • Open Access
95 Citations
14,197 Views
11 Pages

Schisandra chinensis Turcz. (Baill.) fruits, their extracts, and bioactive compounds are used in alternative medicine as adaptogens and ergogens protecting against numerous neurological, cardiovascular, gastrointestinal, liver, and skin disorders. S....

of 13

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Antioxidants - ISSN 2076-3921