Oxidative Stress in Neurodegenerative Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 39831
Special Issue Editors
Interests: Parkinson’s disease; protein aggregation; animal models; fibril-induced alpha-synuclein aggregation; human iPCS-derived neurons; viral vectors for somatic transgenesis; neurotrophic factors; neuroinflammation; autophagy-lysosomal system; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: Huntington’s disease; Parkinson’s disease; amyotropic lateral sclerosis; RNA metabolism; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress, along with mitochondrial dysfunction and pathological protein aggregation, is a hallmark of many neurodegenerative diseases. The brain is particularly susceptible to oxidative stress due to its high oxygen consumption and vulnerable endogenous antioxidant defense. Oxidative stress may lead to the death of neurons, either directly or indirectly, as a consequence of mitochondrial dysfunction, altered proteostasis, physiological neurotransmitter metabolism, inflammation, or deregulation of antioxidant pathways. Indeed, increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS), together with impaired antioxidant defense mechanisms, are frequently observed in Alzheimer’s, Parkinson’s, and Huntington’s diseases and amyotrophic lateral sclerosis (ALS). ROS and RNS cause oxidative damage to proteins, lipids, and nucleic acids, compromising cellular functions and activating cell death pathways. Critical importance of antioxidant defense pathways for neuronal survival is also supported by the genetic mutations observed in familial forms of several neurodegenerative diseases.
For this Special Issue, we aim to bring together the most recent information on the causes and consequences of oxidative stress in neurodegenerative diseases. We invite authors to submit their latest relevant research findings or review articles, including in vitro, in vivo, and clinical studies relating to any of the following topics: molecular and cellular responses to oxidative damage in the brain; age-related and/or disease-specific changes in neuronal antioxidant defense pathways; oxidative stress biomarkers for diagnostic and monitoring disease progression and treatment efficacy; methods to study oxidative stress in neurodegenerative disease models and patients; and antioxidant therapies for neurodegenerative diseases.
We look forward to your contribution.
Dr. Andrii Domanskyi
Dr. Rosanna Parlato
Guest Editors
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Keywords
- reactive oxygen species
- reactive nitrogen species
- neurodegeneration
- antioxidant defence
- oxidative stress biomarkers
- antioxidant therapy
- oxidative stress sensors
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