Special Issue "Health Effects of Coenzyme Q10"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 April 2021).
Interests: oxidative stress, ageing, mitochondrial dysfunction, bioactive quinones, Coenzyme Q10
Interests: bioactive compounds; analytical chromatography; oxidative stress; inflamation; ageing; ROS signaling
Interests: sarcopenia; ageing; oxidative stress; phisycal activity; mitochondrial nutrients; mitochondria
Interests: Skin ageing; senescence; mitochondrial dysfunction; skin inflammation; photoageing; flowcytometery; anti-aging compounds
Interests: cardiovascular disease; neurodegeneration; bioactive molecules; inflammation; oxidative stress; cell biology
Coenzyme Q10 is an endogenous lipophilic quinone ubiquitous in biological membranes, where it exerts functions as an electron carrier and is endowed with antioxidant activities. Since its discovery in 1957 by F.L. Crane the relevance of CoQ10 for human health has been investigated in different clinical settings and its beneficial use as a drug and nutraceutical is acknowledged in diverse conditions ranging from cardiovascular disease, neuromuscular degenerative diseases, fertility, and many more. The mechanism of action of coenzyme Q10 is mainly associated with its bioenergetic role in the mitochondrial respiratory chain and radical scavenging capacity of its reduced form ubiquinol, either direct or in association with other cellular reductive systems. In recent decades, the novel biological functions of coenzyme Q10 have been highlighted, including modulatory effects on gene expression and wider mitochondrial functions, such as the regulation of mitochondrial transition pore and uncoupling proteins. As an endogenous cofactor, alterations in its biosynthesis characterize severe genetic disease associated with CoQ deficiency syndrome, moreover subliminal deficit in the biosynthesis are known to be associated with the ageing process, genetic variants and different pathological conditions.
Improvement in formulation and the availability of ubiquinol has dramatically increased the bioavailability in human trials. The present issue aims to collect novel contributions on the role of CoQ10 on human health and in relation to clinical conditions and aging-related disorders, concerning (but not limited) to the following areas: Cardiovascular, degenerative diseases, sarcopenia, fertility, CoQ biosynthesis mechanisms and those interventions that modulate CoQ in health aging.
Professor Luca Tiano
Dr. Patrick Orlando
Dr. Sonia Silvestri
Dr. Fabio Marcheggiani
Dr. Ilenia Cirilli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Coenzyme Q10
- Mitochondrial dysfunction
- Cardiovascular disease
- Neuro degeneration