Hydrogen Peroxide in Redox Signaling

Dear Colleagues,

Reactive oxygen species (ROS) are involved in the regulation of a vast number of physiological processes as a result of the aerobic metabolism of the organisms. Mechanistically, the effect of ROS is channeled through redox signaling networks consisting of the main signaling cascades downstream of tyrosine kinase receptors (RTKs), small GTPases, and large G protein-coupled receptors (GPCRs), which maintain the redox balance and regulate the oxidative stress. Hydrogen peroxide (H₂O₂) is a well-characterized ROS produced by several redox enzymes. H₂O₂ can inactivate protein tyrosine phosphatases (PTPs) by reversibly oxidizing the reactive cysteine in the active site, thereby allowing the phosphorylation of the cellular kinases at tyrosine or serine residues with subsequent activation of e.g., mitogen, growth, survival, apoptosis, and angiogenesis signaling affecting cardiovascular and tissue damage, degenerative diseases, tumorigenesis, bacterial infections, and microbiota in general.

Therefore, this Special Issue is focused on the production and function of H₂O₂ in redox signaling. The researchers are invited to submit review articles, original research articles, communications, and concept papers covering all aspects related to the topic of the Issue.

Dr. Mikko Laukkanen
Guest Editor

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