Special Issue "Modulators of Oxidative Stress: Chemical and Pharmacological Aspects 2021"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Prof. Dr. Jasmina Dimitrić Marković
Website
Founding Section Editor-in-Chief
Faculty of Physical Chemistry, University of Belgrade, Serbia
Interests: physicochemical aspects of the modulation of oxidative stress

Special Issue Information

Dear Colleagues,

Reactive oxygen (ROS), nitrogen (RNS), and sulfur (RSS) species are implicated in the pathogenesis of a variety of pathological conditions, including chronic infections, inflammatory disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Unfortunately, antioxidant therapies have not demonstrated effectiveness in the majority of clinical studies for various reasons that have been reviewed elsewhere. However, modulation of oxidative stress, particularly through regulation of gene transcription via, e.g., activation or inhibition of Nrf2, is considered to be an important strategy for the development of new drugs for some of these pathologies, such as cardiovascular and neoplastic diseases that are resistant to other treatments. The main aim of this Special Issue is to explore aspects of the modulation of oxidative stress using an interdisciplinary approach involving chemical, biological, physiological, pharmaceutical, pharmacological, and physicochemical perspectives. Potential topics include but are not limited to the following:

  • Synthesis and derivatization of oxidative stress modulators with potential pharmacological applications, and the optimization of their antioxidant properties and bioavailability;
  • Nonradical scavenging mechanisms of action of oxidative stress modulators, particularly of the Keap1/Nrf2/ARE signaling pathway;
  • Pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites;
  • In vitro and in vivo studies on the pharmacological activity of oxidative stress modulators;
  • Epidemiological and clinical studies on the efficacy of redox therapies;
  • Relevant biological markers for assessing in vivo antioxidant/pro-oxidant activity and its correlation with clinical efficacy;
  • Pathological states from the redox point of view
  • Antioxidants vs. oxidative stress—insights from computation
  • Predicting protection against oxidative stress—computational strategies
  • Chemical structure and reactivity of modulators of oxidative stress by means of quantum chemical analysis;
  • The molecular basis of the antioxidant mechanisms of naturally occurring phytochemicals and their synthetic analogues.

Selected references 

  1. Amarowicz R, Pegg RB. Natural antioxidants of plant origin. Adv Food Nutr Res. 2019;90:1‐81
  2. Dimić DS, Marković ZS, Saso L, et al. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxid Med Cell Longev. 2019;2019:2069250.
  3. Panieri E, Saso L. Potential Applications of NRF2 Inhibitors in Cancer Therapy. Oxid Med Cell Longev. 2019
  4. Telkoparan-Akillilar P, Suzen S, Saso L. Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs. Int J Mol Sci. 2019;20(8):2025.
  5. Sova M, Saso L. Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review. Drug Des Devel Ther. 2018;12:3181-3197

Prof. Dr. Luciano Saso
Prof. Dr. Ryszard Amarowicz
Prof. Dr. Jasmina Dimitrić Marković 
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

Open AccessArticle
Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
Antioxidants 2020, 9(11), 1135; https://doi.org/10.3390/antiox9111135 - 16 Nov 2020
Abstract
Acute kidney injury (AKI) is associated with the abrupt loss of kidney function. Oxidative stress plays an important role in the pathophysiology of AKI. Free thiols (R-SH) are crucial components of the extracellular antioxidant machinery and reliably reflect systemic oxidative stress. Lower levels [...] Read more.
Acute kidney injury (AKI) is associated with the abrupt loss of kidney function. Oxidative stress plays an important role in the pathophysiology of AKI. Free thiols (R-SH) are crucial components of the extracellular antioxidant machinery and reliably reflect systemic oxidative stress. Lower levels of thiols represent higher levels of oxidative stress. In this preliminary study, we hypothesized that plasma-free thiols are associated with AKI upon admission to the intensive care unit (ICU). In this study, 301 critically ill patients were included. Plasma samples were taken upon admission, and albumin-adjusted plasma-free thiols were determined. Albumin-adjusted plasma-free thiols were lower in patients with AKI (n = 43, median (interquartile range) 7.28 µmol/g (3.52, 8.95)) compared to patients without AKI (8.50 μmol/g (5.82, 11.28); p < 0.05) upon admission to the ICU. Higher age (B = −0.72), higher levels of neutrophil gelatinase-associated lipocalin (B = −0.002), creatinine (B = −0.01) and lower serum albumin (B = 0.47) were associated with lower free thiol levels. Further, albumin-adjusted free thiol levels were significantly reduced in patients with sepsis (8.30 (5.52–10.64) µmol/g) compared to patients without sepsis (6.95 (3.72–8.92) µmol/g; p < 0.05). Together, albumin-adjusted plasma-free thiols were significantly reduced in patients with AKI and patients with sepsis compared with patients without AKI and sepsis. Full article
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Open AccessArticle
Synthesis, In Vitro Antioxidant Properties and Distribution of a New Cyanothiophene-Based Phenolic Compound in Olive Oil-In-Water Emulsions
Antioxidants 2020, 9(7), 623; https://doi.org/10.3390/antiox9070623 - 16 Jul 2020
Abstract
We synthesized and determined the antioxidant activity and distribution of a new cyanothiophene-based compound, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3,5-dihydroxybenzamide (SIM-53B), in intact stripped olive oil-in-water emulsion. The in vitro antioxidant properties of SIM-53B were evaluated and compared to those for Trolox and resveratrol. Addition [...] Read more.
We synthesized and determined the antioxidant activity and distribution of a new cyanothiophene-based compound, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3,5-dihydroxybenzamide (SIM-53B), in intact stripped olive oil-in-water emulsion. The in vitro antioxidant properties of SIM-53B were evaluated and compared to those for Trolox and resveratrol. Addition of an emulsifier (Tween 20) creates a narrow region, the aqueous–oil interface, and the distribution of SIM-53B can be described by two partition constants: PWI (between aqueous/interfacial regions) and POI (between oil/interfacial regions). The effects of emulsifier concentration expressed in terms of the volume fraction, ΦI, and O/W ratio were also evaluated on its distribution. SIM-53B is predominantly distributed (>90%) in the interfacial region of 1:9 (O/W) olive oil-in-water emulsions at the lowest emulsifier volume fraction (ΦI = 0.005) and only a small fraction is located in the aqueous (<5%) and the oil (<5%) regions. Besides, the concentration of SIM-53B in the interfacial region of the emulsions is ~170–190-fold higher than the stoichiometric concentration, emphasizing the compartmentalization effects. Results suggest that the emulsifier volume fraction is a key parameter that may modulate significantly its concentration in the interface. Our study suggests that cyanothiophene-based compounds may be interesting additives for potential lipid protection in biomembranes or other lipid-based systems. Full article
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