Brain Sciences, Volume 8, Issue 6
June 2018 - 21 articles
Cover Story: Timely and efficient remyelination following demyelinating diseases of the central nervous system such as Multiple Sclerosis is a key component in targeted reparative therapies. The cover page shows a representative electron microscopy image of dorsal white matter in an adult rat spinal cord following lysolecithin (lysophosphatidylcholine—LPC) injection. There is evidence of spontaneous remyelination, albeit with thinner myelin sheaths than those formed during development. In this review, we provide an overview of normal myelination during development, causes for demyelination, and an in-depth discussion of the current and potential future strategies for promoting remyelination.
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