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Brain Sciences, Volume 13, Issue 12

December 2023 - 121 articles

Cover Story: Diagnostic criteria for vestibular migraine (VM) describe this as an episodic disorder. However, some patients report prolonged (>72 h duration) or even persistent VM symptoms, prompting whether a chronic VM variant should be introduced. But is this different from other chronic vestibular syndromes such as persistent postural-perceptual dizziness (PPPD)? PPPD may arise from recurrent VM episodes, but also independently of VM. Whilst there may be subtle clinical differences between these groups, we argue that the underlying mechanisms of persistent dizziness overlap regardless of the trigger. This has implications for the treatment of persistent dizziness in the context of VM, moving away from pharmacotherapy and towards combined physical and cognitive behavioural therapies. View this paper
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Articles (121)

  • Study Protocol
  • Open Access
1,996 Views
10 Pages

Investigating Genetic and Environmental Substrates of the Relationship between Positive Mental Health and Biological Aging—A Study Protocol

  • Francesca Marcon,
  • Miriam Salemi,
  • Cristina D’Ippolito,
  • Angelo Picardi,
  • Virgilia Toccaceli,
  • Lorenza Nisticò,
  • Sabrina Alviti,
  • Ester Siniscalchi,
  • Francesca Salani and
  • Giorgia Maria Varalda
  • + 2 authors

15 December 2023

Background: The Italian National Institute of Health (Istituto Superiore di Sanità) funded a 30-month project (July 2021–January 2024) to conduct a twin study of the relationships between Positive Mental Health (PMH) and cellular longevi...

  • Article
  • Open Access
4 Citations
3,124 Views
13 Pages

Assisted Cycle Therapy (ACT) Improved Self-Efficacy and Exercise Perception in Middle-Age Adults with Down Syndrome

  • Shannon D. R. Ringenbach,
  • Nathaniel E. Arnold,
  • Kori Tucker,
  • Miya K. Rand,
  • Breanna E. Studenka,
  • Stockton B. Ringenbach and
  • Chih-Chia Chen

15 December 2023

Alzheimer’s disease is prevalent in persons with Down syndrome (DS) as early as their 30s and presents as decreased social interaction, coordination, and physical activity. Therefore, changing attitudes and beliefs about exercise is key to incr...

  • Article
  • Open Access
1 Citations
2,352 Views
11 Pages

Drug-Free Noninvasive Thermal Nerve Block: Validation of Sham Devices

  • Michael A. Fishman,
  • Ahish Chitneni,
  • Alaa Abd-Elsayed,
  • Samuel Grodofsky,
  • Ashley M. Scherer,
  • Brendan Schetzner,
  • Malvina Klusek,
  • Stephen R. Popielarski,
  • Stephen Meloni and
  • Steven Falowski
  • + 3 authors

15 December 2023

Headache is a leading cause of disability and suffering. One major challenge in developing device treatments is demonstrating their efficacy given devices’ often-high placebo rate. This paper reviews the importance of validating sham devices as...

  • Article
  • Open Access
12 Citations
4,840 Views
19 Pages

Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells

  • Ekramy Elmorsy,
  • Ayat Al-Ghafari,
  • Huda Al Doghaither,
  • Sara Hashish,
  • Mohamed Salama,
  • Anusha W. Mudyanselage,
  • Lipta James and
  • Wayne G. Carter

14 December 2023

Paraquat (PQ), rotenone (RO), and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are neurotoxicants that can damage human health. Exposure to these neurotoxicants has been linked to neurodegeneration, particularly Parkinson’s disease. Howe...

  • Article
  • Open Access
2,504 Views
13 Pages

14 December 2023

It has been observed that in some people in the acute phase of ischemic stroke (IS) there is a tendency to shift the body weight towards the side more affected by the disease and a tendency to spontaneous movements of the upper and/or lower limbs (no...

  • Article
  • Open Access
1 Citations
2,206 Views
19 Pages

14 December 2023

Exposure to metal mixtures is recognized as a real-life scenario, needing novel studies that can assess their complex effects on brain development. There is still a significant public health concern associated with chronic low levels of metal exposur...

  • Article
  • Open Access
1 Citations
3,600 Views
12 Pages

Therapist-Reported Differences between Teletherapy via Phone and via Videoconferencing

  • Vera Békés,
  • Cédric Gill Ménard,
  • Natale Schmitz and
  • Katie Aafjes-van Doorn

14 December 2023

When therapists provide teletherapy they can choose between teletherapy via phone and teletherapy via videoconferencing, however, little is known about differences between using these two teletherapy formats. We aimed to compare therapists’ att...

  • Review
  • Open Access
2 Citations
2,200 Views
11 Pages

13 December 2023

Stroke is one of the leading causes of disability around the world, presenting unique challenges in motor development during the rehabilitation process. Based on studies in movement and sports science, thorough knowledge has accumulated on the develo...

  • Review
  • Open Access
4 Citations
6,009 Views
30 Pages

12 December 2023

This paper investigates the influence of gestures on foreign language (FL) vocabulary learning. In this work, we first address the state of the art in the field and then delve into the research conducted in our lab (three experiments already publishe...

  • Brief Report
  • Open Access
6 Citations
3,816 Views
9 Pages

GABAA Receptor Benzodiazepine Binding Sites and Motor Impairments in Parkinson’s Disease

  • Nicolaas I. Bohnen,
  • Jaimie Barr,
  • Robert Vangel,
  • Stiven Roytman,
  • Rebecca Paalanen,
  • Kirk A. Frey,
  • Peter J. H. Scott and
  • Prabesh Kanel

12 December 2023

Flumazenil is an allosteric modulator of the γ-aminobutyric acid-A receptor (GABAAR) benzodiazepine binding site that could normalize neuronal signaling and improve motor impairments in Parkinson’s disease (PD). Little is known about how...

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Brain Sci. - ISSN 2076-3425