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Brain Sciences, Volume 11, Issue 1

2021 January - 127 articles

Cover Story: Multiple sclerosis (MS) is a neurodegenerative disease that causes lesion formation and tissue loss or atrophy in the brain. Cognitive and motor challenges are commonly observed in people with MS. Reduced speed of information processing is typically the first sign of cognitive involvement, which in turn broadly affects other cognitive processes including attention, executive function, and memory. The Attention Network Test—Interactions can measure the efficiency of 3 distinct attentional processes—alerting, orienting, and executive control. In this study, we measured attentional efficiencies and gray matter morphometry in a sample of young adults (18–35 years) with relatively mild MS severity. We show that thickness and volume changes in specific gray matter regions correlate with attentional efficiency even in the absence of widespread atrophy. View this paper
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Articles (127)

  • Article
  • Open Access
13 Citations
5,865 Views
16 Pages

When, How, and to What Extent Are Individuals with Unresponsive Wakefulness Syndrome Able to Progress? Neurobehavioral Progress

  • Enrique Noé,
  • Joan Ferri,
  • José Olaya,
  • María Dolores Navarro,
  • Myrtha O’Valle,
  • Carolina Colomer,
  • Belén Moliner,
  • Camilla Ippoliti,
  • Anny Maza and
  • Roberto Llorens

19 January 2021

Accurate estimation of the neurobehavioral progress of patients with unresponsive wakefulness syndrome (UWS) is essential to anticipate their most likely clinical course and guide clinical decision making. Although different studies have described th...

(This article belongs to the Special Issue Recent Advances in the Study of Altered State of Consciousness)
  • Article
  • Open Access
5 Citations
3,600 Views
11 Pages

19 January 2021

Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene...

(This article belongs to the Special Issue The Genetics of Alcohol Use Disorder)
  • Article
  • Open Access
20 Citations
6,639 Views
13 Pages

The Development of Brain Network in Males with Autism Spectrum Disorders from Childhood to Adolescence: Evidence from fNIRS Study

  • Wei Cao,
  • Huilin Zhu,
  • Yan Li,
  • Yu Wang,
  • Wuxia Bai,
  • Uchong Lao,
  • Yingying Zhang,
  • Yan Ji,
  • Sailing He and
  • Xiaobing Zou

18 January 2021

In the current study, functional near-infrared spectroscopy (fNIRS) was used to collect resting-state signals from 77 males with autism spectrum disorders (ASD, age: 6~16.25) and 40 typically developing (TD) males (age: 6~16.58) in the theory-of-mind...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
14 Citations
4,798 Views
14 Pages

18 January 2021

The late indirect (I)-waves recruited by transcranial magnetic stimulation (TMS) over primary motor cortex (M1) can be modulated using I-wave periodicity repetitive TMS (iTMS). The purpose of this study was to determine if the response to iTMS is inf...

(This article belongs to the Special Issue Transcranial Magnetic Stimulation (TMS): Applications in Clinical and Basic Neuroscience)
  • Article
  • Open Access
10 Citations
3,804 Views
21 Pages

18 January 2021

Outcome after cerebral ischemia is often dismal. Reperfusion adds significantly to the ischemic injury itself. Therefore, new strategies targeting ischemia/reperfusion (I/R) injury are critically needed. Poloxamer (P)188, an amphiphilic triblock copo...

(This article belongs to the Special Issue Mitochondria as Therapeutic Target for Acute Brain Pathologies)
  • Article
  • Open Access
18 Citations
3,355 Views
10 Pages

Brain Metastases in Elderly Patients—The Role of Surgery in the Context of Systemic Treatment

  • Martin Proescholdt,
  • Stephanie T. Jünger,
  • Petra Schödel,
  • Karl-Michael Schebesch,
  • Christian Doenitz,
  • Tobias Pukrop,
  • Julius Höhne,
  • Nils-Ole Schmidt,
  • Martin Kocher and
  • Stefan Grau
  • + 4 authors

18 January 2021

In patients with brain metastases (BM), advanced age is considered a negative prognostic factor. To address the potential reasons for that, we assessed 807 patients who had undergone BM resection; 315 patients aged at least 65 years (group A) were co...

  • Article
  • Open Access
13 Citations
3,978 Views
11 Pages

Clinical Efficacy and Safety of Silicone Elastomer Sheet during Decompressive Craniectomy: Anti-Adhesive Role in Cranioplasty

  • Young Ha Kim,
  • Chi Hyung Lee,
  • Chang Hyeun Kim,
  • Dong Wuk Son,
  • Sang Weon Lee,
  • Geun Sung Song and
  • Soon Ki Sung

18 January 2021

(1) Background: Cranioplasty is a surgery to repair a skull bone defect after decompressive craniectomy (DC). If the process of dissection of the epidural adhesion tissue is not performed properly, it can cause many complications. We reviewed the eff...

(This article belongs to the Special Issue Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
21 Citations
4,314 Views
14 Pages

18 January 2021

To extend the application of the late waves of the event-related potentials (ERPs) to multiple modalities, devices and software the underlying physiological mechanisms and responses of the brain for a particular sensory system and mental function mus...

(This article belongs to the Special Issue Quantitative EEG and Cognitive Neuroscience)
  • Article
  • Open Access
8 Citations
4,058 Views
15 Pages

Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study

  • Blake R. Neyland,
  • Christina E. Hugenschmidt,
  • Robert G. Lyday,
  • Jonathan H. Burdette,
  • Laura D. Baker,
  • W. Jack Rejeski,
  • Michael E. Miller,
  • Stephen B. Kritchevsky and
  • Paul J. Laurienti

17 January 2021

Elucidating the neural correlates of mobility is critical given the increasing population of older adults and age-associated mobility disability. In the current study, we applied graph theory to cross-sectional data to characterize functional brain n...

(This article belongs to the Special Issue Functional Brain Imaging of Locomotion in Aging and Age-Related Diseases)
  • Article
  • Open Access
32 Citations
4,737 Views
12 Pages

Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders

  • Vasilios C. Constantinides,
  • Nour K. Majbour,
  • George P. Paraskevas,
  • Ilham Abdi,
  • Bared Safieh-Garabedian,
  • Leonidas Stefanis,
  • Omar M. El-Agnaf and
  • Elisabeth Kapaki

17 January 2021

Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the...

(This article belongs to the Special Issue Cerebrospinal Fluid Biomarkers in Dementia Disorders)
  • Feature Paper
  • Article
  • Open Access
7 Citations
5,875 Views
24 Pages

Ipsi- and Contralateral Oligo- and Polysynaptic Reflexes in Humans Revealed by Low-Frequency Epidural Electrical Stimulation of the Lumbar Spinal Cord

  • Ursula S. Hofstoetter,
  • Simon M. Danner,
  • Brigitta Freundl,
  • Heinrich Binder,
  • Peter Lackner and
  • Karen Minassian

16 January 2021

Epidural electrical stimulation (EES) applied over the human lumbosacral spinal cord provides access to afferent fibers from virtually all lower-extremity nerves. These afferents connect to spinal networks that play a pivotal role in the control of l...

(This article belongs to the Special Issue Mechanisms of Neuromodulation and Rehabilitation after Spinal Cord Injury)
  • Article
  • Open Access
18 Citations
6,386 Views
20 Pages

Identifying Diurnal Variability of Brain Connectivity Patterns Using Graph Theory

  • Farzad V. Farahani,
  • Magdalena Fafrowicz,
  • Waldemar Karwowski,
  • Bartosz Bohaterewicz,
  • Anna Maria Sobczak,
  • Anna Ceglarek,
  • Aleksandra Zyrkowska,
  • Monika Ostrogorska,
  • Barbara Sikora-Wachowicz and
  • Tadeusz Marek
  • + 4 authors

16 January 2021

Significant differences exist in human brain functions affected by time of day and by people’s diurnal preferences (chronotypes) that are rarely considered in brain studies. In the current study, using network neuroscience and resting-state fun...

(This article belongs to the Special Issue Recent Advances in Human Brain Connectivity)
  • Communication
  • Open Access
16 Citations
3,304 Views
9 Pages

16 January 2021

(1) Background: Ultrasound is a well-known tool used for the diagnosis and management of many diseases, including peripheral neuropathies. The main aim of this study was the lexical analysis of the literature on this topic considering the most cited...

(This article belongs to the Special Issue Pathology of Peripheral Neuropathies )
  • Article
  • Open Access
21 Citations
5,556 Views
17 Pages

The Role of Audiovisual Speech in Fast-Mapping and Novel Word Retention in Monolingual and Bilingual 24-Month-Olds

  • Drew Weatherhead,
  • Maria M. Arredondo,
  • Loreto Nácar Garcia and
  • Janet F. Werker

16 January 2021

Three experiments examined the role of audiovisual speech on 24-month-old monolingual and bilinguals’ performance in a fast-mapping task. In all three experiments, toddlers were exposed to familiar trials which tested their knowledge of known w...

(This article belongs to the Special Issue The Impact of Non-Speech Cues on Speech Perception in Infancy)
  • Article
  • Open Access
10 Citations
4,844 Views
12 Pages

A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy

  • Gian Luca Vita,
  • Maria Sframeli,
  • Norma Licata,
  • Alessandra Bitto,
  • Sara Romeo,
  • Francesca Frisone,
  • Annamaria Ciranni,
  • Giovanni Pallio,
  • Federica Mannino and
  • Giuseppe Vita
  • + 5 authors

16 January 2021

Flavocoxid is a blended extract containing baicalin and catechin with potent antioxidant and anti-inflammatory properties due to the inhibition of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes, nuclear factor-κB (NF-κB), tum...

(This article belongs to the Special Issue Advanced Research in Neuromuscular Disorders)
  • Review
  • Open Access
27 Citations
9,569 Views
14 Pages

Epidemiology of Anthropometric Factors in Glioblastoma Multiforme—Literature Review

  • Donata Simińska,
  • Jan Korbecki,
  • Klaudyna Kojder,
  • Patrycja Kapczuk,
  • Marta Fabiańska,
  • Izabela Gutowska,
  • Anna Machoy-Mokrzyńska,
  • Dariusz Chlubek and
  • Irena Baranowska-Bosiacka

16 January 2021

Although glioblastoma multiforme (GBM) is a widely researched cancer of the central nervous system, we still do not know its full pathophysiological mechanism and we still lack effective treatment methods as the current combination of surgery, radiot...

  • Article
  • Open Access
5 Citations
6,382 Views
16 Pages

Traumatic Brain Injury-Related Attention Deficits in Children: A Controlled Treatment Trial with Lisdexamfetamine Dimesylate (Vyvanse)

  • Michael G. Tramontana,
  • Jonathan W. Prokop,
  • Edwin Williamson,
  • Tara Duffie and
  • Hayden LaFever

16 January 2021

Attention deficits are among the most common and persistent impairments resulting from traumatic brain injury (TBI). This study was the first to examine the effects of lisdexamfetamine dimesylate (LDX, Vyvanse) in treating TBI-related attention defic...

(This article belongs to the Special Issue Mild and Moderate Traumatic Brain Injuries: Diagnosis, Assessment Tools, Management and Factors Influencing Recovery)
  • Opinion
  • Open Access
34 Citations
11,755 Views
19 Pages

15 January 2021

Delayed onset muscle soreness (DOMS) is hypothesized to be caused by glutamate excitotoxicity-induced acute compression axonopathy of the sensory afferents in the muscle spindle. Degeneration of the same sensory afferents is implicated in the disease...

(This article belongs to the Section Molecular and Cellular Neuroscience)
  • Article
  • Open Access
21 Citations
5,001 Views
11 Pages

Evaluation of Nociception Using Quantitative Pupillometry and Skin Conductance in Critically Ill Unconscious Patients: A Pilot Study

  • Sara Fratino,
  • Lorenzo Peluso,
  • Marta Talamonti,
  • Marco Menozzi,
  • Lucas Akira Costa Hirai,
  • Francisco A Lobo,
  • Chiara Prezioso,
  • Jacques Creteur,
  • Jean-François Payen and
  • Fabio Silvio Taccone

15 January 2021

Background: Pain assessment is a challenge in critically ill patients, in particular those who are unable to express movements in reaction to noxious stimuli. The purpose of the study was to compare the pupillary response and skin conductance to pain...

  • Article
  • Open Access
37 Citations
7,702 Views
26 Pages

Main Concept, Sequencing, and Story Grammar Analyses of Cinderella Narratives in a Large Sample of Persons with Aphasia

  • Jessica D. Richardson,
  • Sarah Grace Dalton,
  • Kathryn J. Greenslade,
  • Adam Jacks,
  • Katarina L. Haley and
  • Janet Adams

15 January 2021

Recently, a multilevel analytic approach called Main Concept, Sequencing, and Story Grammar (MSSG) was presented along with preliminary normative information. MSSG analyses leverage the strong psychometrics and rich procedural knowledge of both main...

(This article belongs to the Special Issue New Perspectives and Methodologies in the Diagnosis and Rehabilitation of Aphasia)
  • Article
  • Open Access
36 Citations
15,092 Views
13 Pages

Sensory Processing and Aggressive Behavior in Adults with Autism Spectrum Disorder

  • Frank van den Boogert,
  • Bram Sizoo,
  • Pascalle Spaan,
  • Sharon Tolstra,
  • Yvonne H. A. Bouman,
  • Witte J. G. Hoogendijk and
  • Sabine J. Roza

14 January 2021

Autism spectrum disorder (ASD) may be accompanied by aggressive behavior and is associated with sensory processing difficulties. The present study aims to investigate the direct association between sensory processing and aggressive behavior in adults...

  • Article
  • Open Access
57 Citations
6,320 Views
19 Pages

14 January 2021

(1) Background: Cognitive aspects and complexity in modern manual mixed model assembly are increasing. To reduce mental workload (MWL), informational assistance systems are introduced. The influence of complexity and used assistance system on MWL sho...

(This article belongs to the Section Systems Neuroscience)
  • Perspective
  • Open Access
9 Citations
3,819 Views
10 Pages

14 January 2021

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no cure and no effective diagnostic criteria. The greatest challenge in effectively treating AD is identifying biomarkers specific for each patient when neurodegenerative...

(This article belongs to the Special Issue Biochemical Biomarkers and Neurodegenerative Diseases)
  • Article
  • Open Access
19 Citations
7,736 Views
19 Pages

The Effects of Spinal Manipulation on Motor Unit Behavior

  • Lucien Robinault,
  • Aleš Holobar,
  • Sylvain Crémoux,
  • Usman Rashid,
  • Imran Khan Niazi,
  • Kelly Holt,
  • Jimmy Lauber and
  • Heidi Haavik

14 January 2021

Over recent years, a growing body of research has highlighted the neural plastic effects of spinal manipulation on the central nervous system. Recently, it has been shown that spinal manipulation improved outcomes, such as maximum voluntary force and...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Article
  • Open Access
62 Citations
8,243 Views
14 Pages

Gait Recovery with an Overground Powered Exoskeleton: A Randomized Controlled Trial on Subacute Stroke Subjects

  • Franco Molteni,
  • Eleonora Guanziroli,
  • Michela Goffredo,
  • Rocco Salvatore Calabrò,
  • Sanaz Pournajaf,
  • Marina Gaffuri,
  • Giulio Gasperini,
  • Serena Filoni,
  • Silvano Baratta and
  • on behalf of Italian Eksogait Study Group
  • + 4 authors

14 January 2021

Background: Overground Robot-Assisted Gait Training (o-RAGT) provides intensive gait rehabilitation. This study investigated the efficacy of o-RAGT in subacute stroke subjects, compared to conventional gait training. Methods: A multicenter randomized...

(This article belongs to the Special Issue Neurorehabilitation of Cerebrovascular Diseases and Related Cognitive Complications)
  • Article
  • Open Access
19 Citations
5,742 Views
20 Pages

Single-Trial Recognition of Video Gamer’s Expertise from Brain Haemodynamic and Facial Emotion Responses

  • Ana R. Andreu-Perez,
  • Mehrin Kiani,
  • Javier Andreu-Perez,
  • Pratusha Reddy,
  • Jaime Andreu-Abela,
  • Maria Pinto and
  • Kurtulus Izzetoglu

14 January 2021

With an increase in consumer demand of video gaming entertainment, the game industry is exploring novel ways of game interaction such as providing direct interfaces between the game and the gamers’ cognitive or affective responses. In this work...

(This article belongs to the Special Issue Studies in Human Performance and Experience: Neuroscience and Functional Brain Imaging)
  • Article
  • Open Access
22 Citations
6,048 Views
15 Pages

Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood

  • Chi-Wen Jao,
  • Chi Ieong Lau,
  • Li-Ming Lien,
  • Yuh-Feng Tsai,
  • Kuang-En Chu,
  • Chen-Yu Hsiao,
  • Jiann-Horng Yeh and
  • Yu-Te Wu

14 January 2021

Normal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative m...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Perspective
  • Open Access
48 Citations
17,840 Views
12 Pages

13 January 2021

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that has become increasingly prevalent worldwide. Its core symptoms, including difficulties regulating attention, activity level, and impulses, appear in early childhood...

  • Article
  • Open Access
6 Citations
3,271 Views
12 Pages

Slump in Hospital Admissions for Stroke, a Fact of an Uncertain Nature That Requires Explanation

  • José M. Ramírez-Moreno,
  • Juan Carlos Portilla-Cuenca,
  • Roshan Hariramani-Ramchandani,
  • Belen Rebollo,
  • Inés Bermejo Casado,
  • Pablo Macías-Sedas,
  • David Ceberino,
  • Ana M. Roa-Montero,
  • Alberto González-Plata and
  • Luis Fernández de Alarcón
  • + 1 author

13 January 2021

(1) Background: The impact of the health crisis caused by coronavirus disease 2019 (COVID-19) has provoked collateral effects in the attention to pathologies with time-dependent treatments such as strokes. We compare the healthcare activity of two st...

(This article belongs to the Special Issue Collection on Clinical Neuroscience)
  • Article
  • Open Access
10 Citations
3,816 Views
9 Pages

Expanding the Clinical and Mutational Spectrum of the PLP1-Related Hypomyelination of Early Myelinated Structures (HEMS)

  • Francesco Nicita,
  • Chiara Aiello,
  • Gessica Vasco,
  • Massimiliano Valeriani,
  • Fabrizia Stregapede,
  • Andrea Sancesario,
  • Michela Armando and
  • Enrico Bertini

13 January 2021

The PLP1 gene, located on chromosome Xq22, encodes the proteolipid protein 1 and its isoform DM20. Mutations in PLP1 cause a spectrum of white matter disorders of variable severity. Here we report on four additional HEMS patients from three families...

  • Article
  • Open Access
5 Citations
4,540 Views
15 Pages

Assessing the Relationship between Verbal and Nonverbal Cognitive Abilities Using Resting-State EEG Functional Connectivity

  • Inna Feklicheva,
  • Ilya Zakharov,
  • Nadezda Chipeeva,
  • Ekaterina Maslennikova,
  • Svetlana Korobova,
  • Timofey Adamovich,
  • Victoria Ismatullina and
  • Sergey Malykh

13 January 2021

The present study investigates the relationship between individual differences in verbal and non-verbal cognitive abilities and resting-state EEG network characteristics. We used a network neuroscience approach to analyze both large-scale topological...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Article
  • Open Access
9 Citations
6,067 Views
14 Pages

Effects of Sleep on the Academic Performance of Children with Attention Deficit and Hyperactivity Disorder

  • Lorena Villalba-Heredia,
  • Celestino Rodríguez,
  • Zaira Santana,
  • Débora Areces and
  • Antonio Méndez-Giménez

13 January 2021

Attention deficit and hyperactivity disorder (ADHD) is commonly associated with disordered or disturbed sleep and the association of sleep problems with ADHD is complex and multidirectional. The purpose of this study was to analyze the relationship b...

  • Article
  • Open Access
9 Citations
3,590 Views
13 Pages

The Deficit of Multimodal Perception of Congruent and Non-Congruent Fearful Expressions in Patients with Schizophrenia: The ERP Study

  • Galina V. Portnova,
  • Aleksandra V. Maslennikova,
  • Natalya V. Zakharova and
  • Olga V. Martynova

13 January 2021

Emotional dysfunction, including flat affect and emotional perception deficits, is a specific symptom of schizophrenia disorder. We used a modified multimodal odd-ball paradigm with fearful facial expressions accompanied by congruent and non-congruen...

  • Article
  • Open Access
39 Citations
6,264 Views
23 Pages

Comparison of Smoothing Filters’ Influence on Quality of Data Recorded with the Emotiv EPOC Flex Brain–Computer Interface Headset during Audio Stimulation

  • Natalia Browarska,
  • Aleksandra Kawala-Sterniuk,
  • Jaroslaw Zygarlicki,
  • Michal Podpora,
  • Mariusz Pelc,
  • Radek Martinek and
  • Edward Jacek Gorzelańczyk

13 January 2021

Off-the-shelf, consumer-grade EEG equipment is nowadays becoming the first-choice equipment for many scientists when it comes to recording brain waves for research purposes. On one hand, this is perfectly understandable due to its availability and re...

  • Article
  • Open Access
23 Citations
4,288 Views
10 Pages

Internal Carotid Artery Injury in Transsphenoidal Surgery: Tenets for Its Avoidance and Refit—A Clinical Study

  • Dmitry Usachev,
  • Oleg Sharipov,
  • Ashraf Abdali,
  • Sergei Yakovlev,
  • Vasiliy Lukshin,
  • Maksim Kutin,
  • Dmitry Fomichev,
  • Pavel Dorokhov,
  • Evgeny Bukharin and
  • Pavel Kalinin
  • + 5 authors

13 January 2021

One of the most serious/potentially fatal complications of transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoi...

  • Article
  • Open Access
8 Citations
5,164 Views
21 Pages

“My Brain Can Stop”: An ERP Study of Longitudinal Prediction of Inhibitory Control in Adolescence

  • Tzlil Einziger,
  • Mattan S. Ben-Shachar,
  • Tali Devor,
  • Michael Shmueli,
  • Judith G. Auerbach and
  • Andrea Berger

13 January 2021

We examined the longitudinal predictors of electrophysiological and behavioral markers of inhibitory control in adolescence. Participants were 63 adolescent boys who have been followed since birth as part of a prospective longitudinal study on the de...

(This article belongs to the Special Issue New Advances in Attention Deficit Hyperactivity Disorder (ADHD))
  • Article
  • Open Access
44 Citations
18,702 Views
17 Pages

Rhythmic Chanting and Mystical States across Traditions

  • Gemma Perry,
  • Vince Polito and
  • William Forde Thompson

13 January 2021

Chanting is a form of rhythmic, repetitive vocalization practiced in a wide range of cultures. It is used in spiritual practice to strengthen community, heal illness, and overcome psychological and emotional difficulties. In many traditions, chanting...

(This article belongs to the Special Issue Rhythmic Motor Pattern Generation)
  • Case Report
  • Open Access
13 Citations
3,488 Views
13 Pages

KCNA2 Autoimmunity in Progressive Cognitive Impairment: Case Series and Literature Review

  • Charles Timäus,
  • Philipp von Gottberg,
  • Sina Hirschel,
  • Claudia Lange,
  • Jens Wiltfang and
  • Niels Hansen

12 January 2021

Autoimmune dementia is a novel and expanding field which subsumes neuropsychiatric disorders with predominant cognitive impairments due to an underlying autoimmune etiology. Progressive dementias with atypical clinical presentation should trigger a t...

  • Article
  • Open Access
2,933 Views
10 Pages

A R-Script for Generating Multiple Sclerosis Lesion Pattern Discrimination Plots

  • Robert Marschallinger,
  • Carmen Tur,
  • Hannes Marschallinger and
  • Johann Sellner

12 January 2021

One significant characteristic of Multiple Sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is the evolution of highly variable patterns of white matter lesions. Based on geostatistical metrics, the MS-Lesio...

(This article belongs to the Special Issue Investigating Dynamics and Plasticity of Healthy and Injured Neuronal Assemblies: Algorithms, Modelling, and Experiments)
  • Article
  • Open Access
1 Citations
3,552 Views
11 Pages

AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes

  • Hyun-Gug Jung,
  • Ajung Kim,
  • Seung-Chan Kim,
  • Jae-Yong Park and
  • Eun Mi Hwang

11 January 2021

AEG-1, also called MTDH, has oncogenic potential in numerous cancers and is considered a multifunctional modulator because of its involvement in developmental processes and inflammatory and degenerative brain diseases. However, the role of AEG-1 in a...

(This article belongs to the Section Neuroglia)
  • Article
  • Open Access
15 Citations
4,460 Views
16 Pages

11 January 2021

Alzheimer’s disease and related dementias (ADRD), pain and chronic complex conditions (CCC) often co-occur leading to polypharmacy and with potential inappropriate medications (PIMs) use, are important risk factors for adverse drug reactions an...

(This article belongs to the Special Issue Pain Assessment in Impaired Cognition)
  • Review
  • Open Access
100 Citations
13,839 Views
25 Pages

Congenital Disorders of Glycosylation from a Neurological Perspective

  • Justyna Paprocka,
  • Aleksandra Jezela-Stanek,
  • Anna Tylki-Szymańska and
  • Stephanie Grunewald

11 January 2021

Most plasma proteins, cell membrane proteins and other proteins are glycoproteins with sugar chains attached to the polypeptide-glycans. Glycosylation is the main element of the post-translational transformation of most human proteins. Since glycosyl...

(This article belongs to the Section Systems Neuroscience)
  • Article
  • Open Access
13 Citations
7,519 Views
11 Pages

Connectivity Patterns of Deep Brain Stimulation Targets in Patients with Gilles de la Tourette Syndrome

  • Petra Heiden,
  • Mauritius Hoevels,
  • Dilruba Bayram,
  • Juan C. Baldermann,
  • Thomas Schüller,
  • Daniel Huys,
  • Veerle Visser-Vandewalle and
  • Pablo Andrade

11 January 2021

Since 1999, several targets for deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS) have emerged showing similar success rates. Studies using different tractography techniques have identified connectivity profiles associated with a b...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
25 Citations
3,688 Views
11 Pages

Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice

  • Ida Cariati,
  • Roberto Bonanni,
  • Gabriele Pallone,
  • Giuseppe Annino,
  • Virginia Tancredi and
  • Giovanna D’Arcangelo

10 January 2021

In the past 40 years, scientific research has shown how Whole Body Vibration concept represents a strong stimulus for the whole organism. Low (<30 Hz), medium (30–80 Hz), and high (>80 Hz) frequency vibrations can have both positive and n...

(This article belongs to the Special Issue Exercise and Brain Function—Series II)
  • Article
  • Open Access
19 Citations
4,228 Views
8 Pages

10 January 2021

The use of traditional open decompression alone in degenerative spondylolisthesis can lead to the development of postoperative spinal instability, whereas percutaneous endoscopic decompression can preserve the attachment of intervertebral muscles, fa...

(This article belongs to the Special Issue Degenerative Spinal Disease)
  • Opinion
  • Open Access
36 Citations
9,124 Views
12 Pages

Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives

  • Giuseppe Roberto Giammalva,
  • Cesare Gagliardo,
  • Salvatore Marrone,
  • Federica Paolini,
  • Rosa Maria Gerardi,
  • Giuseppe Emmanuele Umana,
  • Kaan Yağmurlu,
  • Bipin Chaurasia,
  • Gianluca Scalia and
  • Rosario Maugeri
  • + 9 authors

10 January 2021

Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tis...

(This article belongs to the Special Issue Neurosurgery and Neuroanatomy)
  • Review
  • Open Access
14 Citations
7,129 Views
10 Pages

Etiology of ‘Sinus Headache’—Moving the Focus from Rhinology to Neurology. A Systematic Review

  • Marcin Straburzyński,
  • Anna Gryglas-Dworak,
  • Magdalena Nowaczewska,
  • Eliza Brożek-Mądry and
  • Paolo Martelletti

‘Sinus headache and/or facial pain’ (SH) is a common complaint encountered by otorhinolaryngologists, neurologists and general practitioners. However, several studies suggested that the majority of those cases may be attributed to primary...

(This article belongs to the Special Issue Collection on Clinical Neuroscience)
  • Article
  • Open Access
9 Citations
6,133 Views
12 Pages

Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis

  • Sindhuja T. Govindarajan,
  • Ruiqi Pan,
  • Lauren Krupp,
  • Leigh Charvet and
  • Tim Q. Duong

Slowed processing on the alerting, orienting and executive control components of attention measured using the Attention Network Test-Interactions (ANT-I) have been widely reported in multiple sclerosis (MS). Despite the assumption that these componen...

(This article belongs to the Special Issue Cognitive Involvement in Multiple Sclerosis)
  • Commentary
  • Open Access
11 Citations
5,237 Views
11 Pages

A debate over the past decade has focused on the so-called bilingual advantage—the idea that bilingual and multilingual individuals have enhanced domain-general executive functions, relative to monolinguals, due to competition-induced monitorin...

(This article belongs to the Section Neurolinguistics)
  • Review
  • Open Access
27 Citations
5,486 Views
16 Pages

Evolution of the Autism Literature and the Influence of Parents: A Scientific Mapping in Web of Science

  • Noemí Carmona-Serrano,
  • Antonio-José Moreno-Guerrero,
  • José-Antonio Marín-Marín and
  • Jesús López-Belmonte

Parents interventions are relevant to address autism spectrum disorder (ASD). The objective of this study is to analyze the importance and evolution of ASD and its relationship with the parents (ASD-PAR) in the publications indexed in Web of Science....

(This article belongs to the Special Issue Connections between Parental Involvement and Treatment of Children with Autism Spectrum Disorders (ASD))

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Brain Sci. - ISSN 2076-3425