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Article

Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis

1
Department of Radiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA
2
Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA
3
Department of Radiology, Albert Einstein College of Medicine and Montefiore Health System, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2021, 11(1), 80; https://doi.org/10.3390/brainsci11010080
Received: 15 December 2020 / Revised: 2 January 2021 / Accepted: 7 January 2021 / Published: 9 January 2021
(This article belongs to the Special Issue Cognitive Involvement in Multiple Sclerosis)
Slowed processing on the alerting, orienting and executive control components of attention measured using the Attention Network Test-Interactions (ANT-I) have been widely reported in multiple sclerosis (MS). Despite the assumption that these components correspond to specific neuroanatomical networks in the brain, little is known about gray matter changes that occur in MS and their association with ANT-I performance. We investigated vertex-wise cortical thickness changes and deep gray matter volumetric changes in young MS participants (N = 21, age range: 18–35) with pediatric or young-adult onset and mild disease severity. ANT-I scores and cortical thickness were not significantly different between MS participants and healthy volunteers (N = 19, age range: 18–35), but thalamic volumes were significantly lower in MS. Slowed reaction times on the alerting component in MS correlated significantly with reduced volume of the right pallidum in MS. Slowed reaction times on executive control component correlated significantly with reduced thickness in the frontal, parietal and visual cortical areas and with reduced volume of the left putamen in MS. These findings demonstrate associations between gray matter changes and attentional performance even in the absence of widespread atrophy or slowed attentional processes. View Full-Text
Keywords: pediatric-onset multiple sclerosis; cognition; executive control; attention; atrophy; cortical thickness; frontoparietal attention network pediatric-onset multiple sclerosis; cognition; executive control; attention; atrophy; cortical thickness; frontoparietal attention network
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MDPI and ACS Style

Govindarajan, S.T.; Pan, R.; Krupp, L.; Charvet, L.; Duong, T.Q. Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis. Brain Sci. 2021, 11, 80. https://doi.org/10.3390/brainsci11010080

AMA Style

Govindarajan ST, Pan R, Krupp L, Charvet L, Duong TQ. Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis. Brain Sciences. 2021; 11(1):80. https://doi.org/10.3390/brainsci11010080

Chicago/Turabian Style

Govindarajan, Sindhuja T., Ruiqi Pan, Lauren Krupp, Leigh Charvet, and Tim Q. Duong. 2021. "Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis" Brain Sciences 11, no. 1: 80. https://doi.org/10.3390/brainsci11010080

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