Cerebrospinal Fluid Biomarkers in Dementia Disorders
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 32706
Special Issue Editor
Interests: dementia; neurodegenerative disorders; Alzheimer’s disease; Lewy body synucle-inopathies; frontotemporal lobar degenerations; tauopathies; TDP43 proteinopa-thies; vascular cognitive impairment; cerebrospinal fluid biomarkers; neurochem-istry; neuropsychology; neuroimaging
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Special Issue Information
Dear Colleagues,
Alzheimer’s disease and most other neurodegenerative dementia disorders are currently viewed as proteinopathies, being characterized by the aggregation of one or more protein(s) or peptides. Some of these proteins and peptides, including tau, phospho-tau, amyloid-beta, alpha-synuclein, and TDP-43, can be detected and quantified in the cerebrospinal fluid, an important means for the diagnostic workup of dementia disorders and the interpretation of underlying biochemical mechanisms. Furthermore, Alzheimer’s disease (and probably other cognitive disorders) is considered as a neurobiological continuum, regardless of its clinical presentation. Thus, biomarkers may be helpful not only at the dementia stage but also across all stages of the disease(s), including the predementia symptomatic stage (mild cognitive impairment) and the preclinical stage, also contributing to early diagnosis and correct classification of subjects enrolled in clinical trials and receiving emerging, disease-modifying treatments. The upcoming Special Issue will highlight the most recent advances in the use of cerebrospinal fluid biomarkers for the diagnosis and understanding of dementing disorders.
Dr. George P. Paraskevas
Guest Editor
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Keywords
- cerebrospinal fluid
- tau protein
- phospho-tau
- amyloid beta peptide
- TDP43
- Alzheimer’s disease
- Lewy body disorders
- frontotemporal lobar degenerations
- vascular cognitive impairment
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