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Brain Sciences, Volume 10, Issue 6

June 2020 - 86 articles

Cover Story: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is considered to be the leading nontraumatic cause of neurological disability in young adults. The Holy Grail for the treatment of MS is to specifically suppress the disease while at the same time allow the immune system to be active against infections and malignancy. This could be achieved by developing immunotherapies designed to specifically suppress immune responses to myelin antigens. This study aims to review different myelin antigen-specific strategies for the prevention/treatment of MS and the challenges they face in being translated to MS patients. View this paper
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Articles (86)

  • Article
  • Open Access
18 Citations
3,737 Views
27 Pages

Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective

  • C. Leonardo Jimenez Chavez,
  • Michal A. Coelho,
  • Lindsey W. Brewin,
  • Isaiah Swauncy,
  • Tori Tran,
  • Taylor Albanese,
  • Angie Laguna,
  • Ivette Gabriela and
  • Karen K. Szumlinski

A prior history of excessive drinking induces a negative affective state in both humans and laboratory rodents, the manifestation of which varies with the age of drinking-onset. In adolescent male mice, negative affect incubates over the course of a...

  • Article
  • Open Access
19 Citations
3,939 Views
26 Pages

Deafness in both ears is highly disruptive to communication in everyday listening situations. Many individuals with profound deafness receive bilateral cochlear implants (CIs) to gain access to spatial cues used in localization and speech understandi...

  • Article
  • Open Access
11 Citations
4,447 Views
23 Pages

Neurodynamics of Patients during a Dolphin-Assisted Therapy by Means of a Fractal Intraneural Analysis

  • Oswaldo Morales Matamoros,
  • Jesús Jaime Moreno Escobar,
  • Ricardo Tejeida Padilla and
  • Ixchel Lina Reyes

The recent proliferation of sensor technology applications in therapies for children’s disabilities to promote positive behavior among such children has produced optimistic results in developing a variety of skills and abilities in them. Dolphi...

  • Article
  • Open Access
15 Citations
6,957 Views
20 Pages

Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potent...

  • Brief Report
  • Open Access
17 Citations
4,648 Views
11 Pages

Increased Neural Reward Responsivity in Adolescents with ASD after Social Skills Intervention

  • Elizabeth Baker,
  • Elina Veytsman,
  • Ann Marie Martin,
  • Jan Blacher and
  • Katherine K. M. Stavropoulos

The reward system has been implicated as a potential neural mechanism underlying social-communication deficits in individuals with autism spectrum disorder (ASD). However, it remains unclear whether the neural reward system in ASD is sensitive to beh...

  • Article
  • Open Access
25 Citations
3,999 Views
12 Pages

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

  • Martin Klietz,
  • Theresa Schnur,
  • Simon C. Drexel,
  • Florian Lange,
  • Lejla Paracka,
  • Meret K. Huber,
  • Dirk Dressler,
  • Günter U. Höglinger and
  • Florian Wegner

Parkinson’s disease (PD) is the second most frequent neurodegenerative disease of people who are beyond 50 years of age. People with PD (PwP) suffer from a large variety of motor and non-motor symptoms resulting in reduced health-related qualit...

  • Article
  • Open Access
29 Citations
6,692 Views
14 Pages

Amplified Concern for Social Risk in Adolescence: Development and Validation of a New Measure

  • Jack L. Andrews,
  • Lucy E. Foulkes,
  • Jessica K. Bone and
  • Sarah-Jayne Blakemore

In adolescence, there is a heightened propensity to take health risks such as smoking, drinking or driving too fast. Another facet of risk taking, social risk, has largely been neglected. A social risk can be defined as any decision or action that co...

  • Article
  • Open Access
16 Citations
18,079 Views
11 Pages

Human Figure Drawings in Children with Autism Spectrum Disorders: A Possible Window on the Inner or the Outer World

  • Pamela Papangelo,
  • Martina Pinzino,
  • Susanna Pelagatti,
  • Maddalena Fabbri-Destro and
  • Antonio Narzisi

Background: Tests based on human figure drawings (HFD) have captured the attention of clinicians and psychologists for a long time. The aim of the present study was to evaluate the performance of HFD of children with autism spectrum disorders (ASDs)...

  • Article
  • Open Access
19 Citations
4,299 Views
11 Pages

Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency

  • Anna Grzywacz,
  • Wojciech Barczak,
  • Jolanta Chmielowiec,
  • Krzysztof Chmielowiec,
  • Aleksandra Suchanecka,
  • Grzegorz Trybek,
  • Jolanta Masiak,
  • Paweł Jagielski,
  • Katarzyna Grocholewicz and
  • Blazej Rubiś

The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, as well as epigenetic factors. Many studies have attempted to discover a molecular basis for this disease. However, our study aimed at e...

  • Case Report
  • Open Access
10 Citations
4,390 Views
12 Pages

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies

  • Dominique Endres,
  • Harald Prüss,
  • Michel Rijntjes,
  • Tina Schweizer,
  • Rita Werden,
  • Kathrin Nickel,
  • Sophie Meixensberger,
  • Kimon Runge,
  • Horst Urbach and
  • Katharina Domschke
  • + 2 authors

Background: Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the contex...

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Brain Sci. - ISSN 2076-3425