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Article

Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective

1
Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, CA 93196-9660, USA
2
Department of Psychology, California State University Dominguez Hills, Carson, CA 90747-0001, USA
3
Department of Molecular, Cellular and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106-6050, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(6), 405; https://doi.org/10.3390/brainsci10060405
Received: 23 April 2020 / Revised: 19 June 2020 / Accepted: 24 June 2020 / Published: 26 June 2020
A prior history of excessive drinking induces a negative affective state in both humans and laboratory rodents, the manifestation of which varies with the age of drinking-onset. In adolescent male mice, negative affect incubates over the course of a 30-day alcohol withdrawal period. In contrast, the negative affect exhibited by adult male mice is robust at 1 day withdrawal, but dissipates with the passage of time. As females tend to consume more alcohol than males, we aimed to explore the affective disturbances exhibited by adolescent and adult C57BL/6J mice of both sexes during more protracted alcohol withdrawal and to relate any behavioral changes observed to plasma corticosterone levels as a biochemical index of stress. Male and female, adolescent and adult, mice were subjected to 14 consecutive days of binge alcohol-drinking using a multi-bottle-choice Drinking-in-the-Dark (DID) procedure (5, 10, 20 and 40% v/v). Age- and sex-matched control mice consumed water only. On either withdrawal day 1 or 70, subgroups of animals were subjected a to 1-day behavioral test battery that included the light–dark box shuttle test, marble-burying test, and Porsolt forced swim test. As expected, adolescent mice consumed more alcohol than adults and females consumed more alcohol than males. However, despite binge-like levels of alcohol consumption, we detected relatively few signs of alcohol withdrawal-induced negative affect and there was no correlation between affective behavior and circulating corticosterone levels. We discuss these findings within the context of our published work, highlighting procedural differences that might account for the relatively weak effect of binge-drinking history upon anxiety and depressive-like behavior observed herein. View Full-Text
Keywords: binge-drinking; negative affect; anxiety; sex differences; adolescence; withdrawal binge-drinking; negative affect; anxiety; sex differences; adolescence; withdrawal
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MDPI and ACS Style

Jimenez Chavez, C.L.; Coelho, M.A.; Brewin, L.W.; Swauncy, I.; Tran, T.; Albanese, T.; Laguna, A.; Gabriela, I.; Szumlinski, K.K. Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective. Brain Sci. 2020, 10, 405. https://doi.org/10.3390/brainsci10060405

AMA Style

Jimenez Chavez CL, Coelho MA, Brewin LW, Swauncy I, Tran T, Albanese T, Laguna A, Gabriela I, Szumlinski KK. Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective. Brain Sciences. 2020; 10(6):405. https://doi.org/10.3390/brainsci10060405

Chicago/Turabian Style

Jimenez Chavez, C. L., Michal A. Coelho, Lindsey W. Brewin, Isaiah Swauncy, Tori Tran, Taylor Albanese, Angie Laguna, Ivette Gabriela, and Karen K. Szumlinski 2020. "Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective" Brain Sciences 10, no. 6: 405. https://doi.org/10.3390/brainsci10060405

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