Open AccessArticle
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy
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Gohar Hakobyan 1, Hasmik Davtyan 1, Kristine Harutyunyan 1, Knarik Alexanyan 2, Yelizaveta Amirkhanyan 3, Anna L. Gharibyan 4,*, Liana Asatryan 5,* and Yuri Tadevosyan 1,†
1
Laboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, Armenia
2
Center of Oncology after V. Fanarjyan, Ministry of Health RA, 0052 Yerevan, Armenia
3
Center of Hematology after R. Yeolyan, Ministry of Health RA, 0014 Yerevan, Armenia
4
Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden
5
School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
†
Prof. Yuri Tadevosyan passed away recently.
Cited by 5 | Viewed by 3422
Abstract
Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MNCs) play
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Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MNCs) play an important role in antitumor immune response by reacting to cancerous modifications in distant organs. In the current study, we tested the hypothesis that tumor initiation and development are reflected in the alteration pattern of the MNC PL component. We analyzed MNC membrane PL fractions in samples from healthy individuals and from patients with diverse types of cancers to reveal possible alterations induced by malignancy. Compared to healthy controls, the cancer samples demonstrated shifts in several membrane PL profiles. In particular, when analyzing cancer data pooled together, there were significantly higher levels in lysophosphatidylcholine, phosphatidylcholine, and phosphatidylethanolamine fractions, and significantly lower quantities in phosphatidylinositol, phosphatidylserine, and phosphatidic acid fractions in cancer samples compared to controls. The levels of sphingomyelins and diphosphatidylglycerols were relatively unaffected. Most of the differences in PLs were sustained during the analysis of individual cancers such as breast cancer and chronic lymphocytic leukemia. Our findings suggest the presence of a common pattern of changes in MNC PLs during malignancy.
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