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Open AccessArticle

Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy

1
Laboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, Armenia
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Center of Oncology after V. Fanarjyan, Ministry of Health RA, 0052 Yerevan, Armenia
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Center of Hematology after R. Yeolyan, Ministry of Health RA, 0014 Yerevan, Armenia
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Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden
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School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
*
Authors to whom correspondence should be addressed.
Prof. Yuri Tadevosyan passed away recently.
Med. Sci. 2018, 6(4), 105; https://doi.org/10.3390/medsci6040105
Received: 23 October 2018 / Revised: 15 November 2018 / Accepted: 20 November 2018 / Published: 23 November 2018
(This article belongs to the Section Cancer and Cancer-Related Research)
Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MNCs) play an important role in antitumor immune response by reacting to cancerous modifications in distant organs. In the current study, we tested the hypothesis that tumor initiation and development are reflected in the alteration pattern of the MNC PL component. We analyzed MNC membrane PL fractions in samples from healthy individuals and from patients with diverse types of cancers to reveal possible alterations induced by malignancy. Compared to healthy controls, the cancer samples demonstrated shifts in several membrane PL profiles. In particular, when analyzing cancer data pooled together, there were significantly higher levels in lysophosphatidylcholine, phosphatidylcholine, and phosphatidylethanolamine fractions, and significantly lower quantities in phosphatidylinositol, phosphatidylserine, and phosphatidic acid fractions in cancer samples compared to controls. The levels of sphingomyelins and diphosphatidylglycerols were relatively unaffected. Most of the differences in PLs were sustained during the analysis of individual cancers such as breast cancer and chronic lymphocytic leukemia. Our findings suggest the presence of a common pattern of changes in MNC PLs during malignancy. View Full-Text
Keywords: cancers; mononuclear cells; plasma membrane; phospholipids; biomarkers cancers; mononuclear cells; plasma membrane; phospholipids; biomarkers
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Hakobyan, G.; Davtyan, H.; Harutyunyan, K.; Alexanyan, K.; Amirkhanyan, Y.; Gharibyan, A.L.; Asatryan, L.; Tadevosyan, Y. Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy. Med. Sci. 2018, 6, 105.

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