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Medical Sciences, Volume 13, Issue 4

December 2025 - 54 articles

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Articles (54)

  • Systematic Review
  • Open Access

Integrating Mental Health into Diabetes Care: Closing the Treatment Gap for Better Outcomes—A Systematic Review

  • Shakila Jahan Shimu,
  • Shamima Akter,
  • Md. Majedur Rahman,
  • Shahida Arbee,
  • Mohammad Sarif Mohiuddin,
  • Sadman Sazzad,
  • Mahjabin Raiqa,
  • Mohammad Mohabbulla Mohib,
  • Afsana R. Munmun and
  • Mohammad Borhan Uddin

3 November 2025

Background: Diabetes and mental health conditions frequently co-occur, with depression and anxiety affecting up to 20–30% of people with diabetes. These comorbidities worsen glycemic control, adherence, and quality of life, yet mental health is...

  • Systematic Review
  • Open Access

3 November 2025

Background: Osteonecrosis of the femoral head is a progressive disorder leading to femoral head collapse and early disability, often affecting young adults. Core decompression (CD) is the most established hip-preserving treatment for early-stage dise...

  • Article
  • Open Access
40 Views
16 Pages

1 November 2025

Background: Renal Cell Carcinoma (RCC) is the most common type of kidney cancer and requires accurate histopathological grading for effective prognosis and treatment planning. However, manual grading is time-consuming, subjective, and susceptible to...

  • Systematic Review
  • Open Access
57 Views
18 Pages

Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review

  • Oana-Mădălina Manole,
  • Gabriela Rusu-Zota,
  • Amin Bazyani and
  • Viviana Onofrei

31 October 2025

Background: Agmatine (AG) is an endogenous neurotransmitter discovered in 1910. It acts on imidazoline I1 and I2 receptors, alpha-2 adrenoceptors, N-methyl-D-aspartate receptors (NMDAR), and serotonergic receptors and modulates nitric oxide synthase...

  • Article
  • Open Access
75 Views
10 Pages

Mismatch Repair System Gene Expression in FFPE Samples from Breast Cancer Patients

  • Ricardo Quidute,
  • Patricia Quidute,
  • Matheus Moreira Perez,
  • Carlos Henrique F. Peiró,
  • Glaucia Luciano da Veiga,
  • Beatriz da Costa Aguiar Alves and
  • Fernando Luiz Affonso Fonseca

31 October 2025

Background/Objectives: Cancer characteristics are mainly due to mutations in genes that regulate key pathways. One mechanism for identifying and correcting these mutations is the Mismatch Repair System. Given the lack of data on MMR in breast cancer...

  • Review
  • Open Access
64 Views
19 Pages

Should We Fear the Frail? A Review on the Impact of Frailty on Liver Surgery

  • Sorinel Lunca,
  • Stefan Morarasu,
  • Raluca Zaharia,
  • Ana Maria Musina,
  • Wee Liam Ong,
  • Gabriel Mihail Dimofte and
  • Cristian Ene Roata

31 October 2025

Background: Frailty is a multidimensional syndrome characterized by reduced physiological reserve and resilience and has become a crucial predictor of outcomes in liver surgery. Unlike chronological age, frailty reflects broader vulnerabilities that...

  • Article
  • Open Access
157 Views
20 Pages

Impact of Corticosteroids in Suprascapular Nerve Block on Pain and Function in Chronic Rotator Cuff Disease: A Retrospective, Observational, Longitudinal, Analytical Cohort Study

  • Javier Muñoz-Paz,
  • Ana Belén Jiménez-Jiménez,
  • Antonio Hidalgo-Jorge,
  • María Nieves Muñoz-Alcaraz,
  • José Peña-Amaro and
  • Fernando Jesús Mayordomo-Riera

31 October 2025

Background/Objectives: Suprascapular nerve block (SSNB) is a useful therapeutic option for chronic shoulder pain, although the synergistic use of corticosteroids with anesthetics to prolong its effect is a controversial topic. The primary objective o...

  • Review
  • Open Access
55 Views
19 Pages

MicroRNAs Regulating Oxidative Stress in Human Fertility: A Narrative Review of Mechanistic Insights and Clinical Potential

  • Ioanna Vassilaki,
  • Anastasios Potiris,
  • Ekaterini Domali,
  • Theodoros Karampitsakos,
  • Despoina Mavrogianni,
  • Themos Grigoriadis,
  • Athanasios Zikopoulos,
  • Efthalia Moustakli,
  • Argyro Papadopoulou and
  • Ismini Anagnostaki
  • + 3 authors

31 October 2025

Human infertility represents a multifaceted condition, with oxidative stress (OS) and microRNAs (miRNAs) emerging as key contributors to its pathophysiology. This comprehensive review explores the complex interplay between reactive oxygen species (RO...

  • Article
  • Open Access
141 Views
15 Pages

Temporal Trends in Cardiovascular Health Metrics in Italy, 2015–2024: A Ten-Year Report from the Longevity Check-Up (Lookup) 8+ Study

  • Stefano Cacciatore,
  • Elena Levati,
  • Riccardo Calvani,
  • Matteo Tosato,
  • Francesca Ciciarello,
  • Vincenzo Galluzzo,
  • Sara Salini,
  • Andrea Russo,
  • Emanuele Marzetti and
  • Francesco Landi

30 October 2025

Background/Objectives: The objective of this ten-year report is to describe temporal trends in the cardiovascular health (CVH) score and its individual components across ages and sexes. We also examined the impact of the post-COVID-19 period on ideal...

  • Article
  • Open Access
144 Views
20 Pages

Elevated NIS Expression Correlates with Chemoresistance in Triple-Negative Breast Cancer: Potential Link to FOXA1 Activity

  • Grigory Demyashkin,
  • Anastasia Guzik,
  • Mikhail Parshenkov,
  • Dmitriy Belokopytov,
  • Vladimir Shchekin,
  • Maxim Batov,
  • Petr Shegai and
  • Andrei Kaprin

30 October 2025

Background: Sodium/iodide symporter (NIS) is a membrane protein involved in iodide transport into cells, making it a key component of thyroid physiology and radioiodine therapy for thyroid cancer. Although NIS is expressed in many extrathyroidal tiss...

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Med. Sci. - ISSN 2076-3271Creative Common CC BY license