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Microorganisms, Volume 6, Issue 2

June 2018 - 28 articles

Cover Story: Mars is currently considered relatively inhospitable due to its freezing temperatures, among other factors. Should life currently exist on the planet, it would likely consist of subsurface microorganisms capable of surviving and/or metabolizing at cold temperatures. Methanogens are found in a wide variety of environments on Earth, ranging from seafloor hydrothermal vents to arctic permafrost. Two non-psychrophilic species of methanogens, Methanobacterium formicicum and Methanothermobacter wolfeii, have been shown capable of active growth following long-term exposure (~4 years) to freezing temperatures. View the paper here.
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Articles (28)

  • Article
  • Open Access
15 Citations
6,645 Views
15 Pages

Binding of Helicobacter pylori to Human Gastric Mucins Correlates with Binding of TFF1

  • Ciara Dunne,
  • Julie Naughton,
  • Gina Duggan,
  • Catherine Loughrey,
  • Michelle Kilcoyne,
  • Lokesh Joshi,
  • Stephen Carrington,
  • Helen Earley,
  • Steffen Backert and
  • Catherine Robbe Masselot
  • + 2 authors

Helicobacter pylori binds to the gastric mucin, MUC5AC, and to trefoil factor, TFF1, which has been shown to interact with gastric mucin. We examined the interactions of TFF1 and H. pylori with purified gastrointestinal mucins from different animal s...

  • Review
  • Open Access
16 Citations
6,128 Views
9 Pages

Mucoralean invasive fungal infections, while unusual among the general population, have a high mortality rate among immunocompromised individuals who become infected. They are also common spoilage organisms in cultured dairy products, some fresh prod...

  • Brief Report
  • Open Access
5 Citations
4,324 Views
9 Pages

Methanogens have been considered models for life on Mars for many years. In order to survive any exposure at the surface of Mars, methanogens would have to endure Martian UVC radiation. In this research, we irradiated hydrated and desiccated cultures...

  • Review
  • Open Access
46 Citations
9,865 Views
19 Pages

Genetic Tools and Techniques for Recombinant Expression in Thermophilic Bacillaceae

  • Eivind B. Drejer,
  • Sigrid Hakvåg,
  • Marta Irla and
  • Trygve Brautaset

Although Escherichia coli and Bacillus subtilis are the most prominent bacterial hosts for recombinant protein production by far, additional species are being explored as alternatives for production of difficult-to-express proteins. In particular, fo...

  • Article
  • Open Access
4 Citations
6,097 Views
20 Pages

For the first time, the differential rates of synthesis of all the key monooxygenases involved in the catabolism by Pseudomonas putida NCIMB 10007 of bicyclic (rac)-camphor to ∆2,5-3,4,4-trimethylpimelyl-CoA, the first aliphatic pathway intermediate,...

  • Review
  • Open Access
37 Citations
8,602 Views
26 Pages

The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?

  • Cécile Formosa-Dague,
  • Mickaël Castelain,
  • Hélène Martin-Yken,
  • Karen Dunker,
  • Etienne Dague and
  • Marit Sletmoen

Bacterial adhesion is currently the subject of increased interest from the research community, leading to fast progress in our understanding of this complex phenomenon. Resent research within this field has documented the important roles played by gl...

  • Review
  • Open Access
19 Citations
5,831 Views
9 Pages

Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges in diagnosis and management due to higher morbidity, effect on growth plate with as...

  • Review
  • Open Access
242 Citations
35,509 Views
23 Pages

Comparison of Yeasts as Hosts for Recombinant Protein Production

  • Antonio Milton Vieira Gomes,
  • Talita Souza Carmo,
  • Lucas Silva Carvalho,
  • Frederico Mendonça Bahia and
  • Nádia Skorupa Parachin

Recombinant protein production emerged in the early 1980s with the development of genetic engineering tools, which represented a compelling alternative to protein extraction from natural sources. Over the years, a high level of heterologous protein w...

  • Article
  • Open Access
5 Citations
5,160 Views
14 Pages

Recombinant Inga Laurina Trypsin Inhibitor (ILTI) Production in Komagataella Phaffii Confirms Its Potential Anti-Biofilm Effect and Reveals an Anti-Tumoral Activity

  • Fábio C. Carneiro,
  • Simone S. Weber,
  • Osmar N. Silva,
  • Ana Cristina Jacobowski,
  • Marcelo H. S. Ramada,
  • Maria L. R. Macedo,
  • Octávio L. Franco and
  • Nádia S. Parachin

Protease inhibitors have a broad biotechnological application ranging from medical drugs to anti-microbial agents. The Inga laurina trypsin inhibitor (ILTI) previously showed a great in vitro inhibitory effect under the adherence of Staphylococcus sp...

  • Review
  • Open Access
24 Citations
4,967 Views
16 Pages

There is great geographical variation in the frequency of Escherichia coli O157 infections that correlates with important differences in the bovine reservoir of each country. Our group carried out a broad molecular characterization of human and bovin...

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Microorganisms - ISSN 2076-2607