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Microorganisms 2018, 6(2), 40;

Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections

Pediatric Infectious Disease, Unity Point Health and Siouxland Medical Education Foundation, 2720 Stone Park Blvd, Sioux City, IA 51104, USA
Pediatric Infectious Disease, Department of Pediatrics St. Joseph’s Children’s Hospital 703, Main Street, Paterson, NJ 07503, USA
Author to whom correspondence should be addressed.
Received: 13 March 2018 / Revised: 27 April 2018 / Accepted: 27 April 2018 / Published: 4 May 2018
(This article belongs to the Special Issue Staphylococcus aureus Infection and Antimicrobial Resistance)
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Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges in diagnosis and management due to higher morbidity, effect on growth plate with associated long-lasting sequelae, and challenges in early identification and management. Methicillin-resistant Staphylococcus aureus (MRSA), first described in the 1960s, has evolved rapidly to emerge as a predominant cause of OSI in children, and therefore empiric treatment for OSI should include an antibiotic effective against MRSA. Characterizing MRSA strains can be done by antimicrobial susceptibility testing, detection of Panton–Valentine leukocidin (PVL) gene, staphylococcal cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). Worldwide, community-onset methicillin-resistant staphylococcal disease is widespread and is mainly associated with a PVL-producing clone, ST8/USA300. Many studies have implied a correlation between PVL genes and more severe infection. We review MRSA OSI along with the pertinent aspects of its pathogenesis, clinical spectrum, diagnosis, and current guidelines for management. View Full-Text
Keywords: osteoarticular infections; methicillin-resistant Staphylococcus aureus; children osteoarticular infections; methicillin-resistant Staphylococcus aureus; children
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kaushik, A.; Kest, H. Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections. Microorganisms 2018, 6, 40.

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