Next Article in Journal
Regulation of Camphor Metabolism: Induction and Repression of Relevant Monooxygenases in Pseudomonas putida NCIMB 10007
Next Article in Special Issue
PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance
Previous Article in Journal
The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?
Previous Article in Special Issue
Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Microorganisms 2018, 6(2), 40; https://doi.org/10.3390/microorganisms6020040

Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections

1
Pediatric Infectious Disease, Unity Point Health and Siouxland Medical Education Foundation, 2720 Stone Park Blvd, Sioux City, IA 51104, USA
2
Pediatric Infectious Disease, Department of Pediatrics St. Joseph’s Children’s Hospital 703, Main Street, Paterson, NJ 07503, USA
*
Author to whom correspondence should be addressed.
Received: 13 March 2018 / Revised: 27 April 2018 / Accepted: 27 April 2018 / Published: 4 May 2018
(This article belongs to the Special Issue Staphylococcus aureus Infection and Antimicrobial Resistance)
Full-Text   |   PDF [220 KB, uploaded 4 May 2018]

Abstract

Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges in diagnosis and management due to higher morbidity, effect on growth plate with associated long-lasting sequelae, and challenges in early identification and management. Methicillin-resistant Staphylococcus aureus (MRSA), first described in the 1960s, has evolved rapidly to emerge as a predominant cause of OSI in children, and therefore empiric treatment for OSI should include an antibiotic effective against MRSA. Characterizing MRSA strains can be done by antimicrobial susceptibility testing, detection of Panton–Valentine leukocidin (PVL) gene, staphylococcal cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). Worldwide, community-onset methicillin-resistant staphylococcal disease is widespread and is mainly associated with a PVL-producing clone, ST8/USA300. Many studies have implied a correlation between PVL genes and more severe infection. We review MRSA OSI along with the pertinent aspects of its pathogenesis, clinical spectrum, diagnosis, and current guidelines for management. View Full-Text
Keywords: osteoarticular infections; methicillin-resistant Staphylococcus aureus; children osteoarticular infections; methicillin-resistant Staphylococcus aureus; children
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kaushik, A.; Kest, H. Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections. Microorganisms 2018, 6, 40.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top