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Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin
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Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

1
Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, S-141 04 Huddinge, Sweden
2
Department of Biochemistry, University of Turku, FI-20014 Turku, Finland
3
Department of Odontology, Umeå University, S-901 87 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 222; https://doi.org/10.3390/pathogens8040222
Received: 27 September 2019 / Revised: 29 October 2019 / Accepted: 4 November 2019 / Published: 6 November 2019
Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation. Because of the large genetic diversity within the species, both harmless and highly virulent genotypes of the bacterium have emerged. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present review, the virulence and pathogenicity properties of A. actinomycetemcomitans will be addressed.
Keywords: Aggregatibacter actinomycetemcomitans; leukotoxin; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomic Aggregatibacter actinomycetemcomitans; leukotoxin; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomic
MDPI and ACS Style

Belibasakis, G.N.; Maula, T.; Bao, K.; Lindholm, M.; Bostanci, N.; Oscarsson, J.; Ihalin, R.; Johansson, A. Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans. Pathogens 2019, 8, 222.

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