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Pathogens, Volume 14, Issue 3

March 2025 - 95 articles

Cover Story: HIV infection cannot be cured due to latently infected cells carrying intact but inactive HIV DNA, making them indistinguishable from uninfected cells. Several strategies have been developed to cure HIV infection, including the reactivation of HIV in latently infected cells, resulting in recognition and death—the “shock and kill” approach. Various latency-reversing agents (LRAs) have been tested in clinical trials. Some were successful in reactivating HIV in vivo and induced detectable changes in the reservoir. Though the technique is not yet curative, these trials prove that latently infected cells can be targeted. In combination with the latest immunomodulatory drugs that aid in killing cells that replicate HIV, new strategies and novel LRAs may be developed in the near future to cure HIV infection. View this paper
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Articles (95)

  • Article
  • Open Access
864 Views
10 Pages

Susceptibility to Postbiotic Substances-Enterocins of the Strains Enterococcus thailandicus from Beavers (Castor fiber)

  • Andrea Lauková,
  • Valentína Focková,
  • Marián Maďar,
  • Renata Miltko and
  • Monika Pogány Simonová

Eurasian beaver (Castor fiber) populations have been reintroduced to European countries, though this bears the risk of novel wildlife pathogen reservoir establishment. The species nova E. thailandicus was described first in Thailand as a food-derived...

  • Review
  • Open Access
3 Citations
3,863 Views
13 Pages

Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement

  • Mathew Choaji,
  • Ascel Samba-Louaka,
  • Zineb Fechtali-Moute,
  • Willy Aucher and
  • Sébastien Pomel

The free-living amoeba Acanthamoeba castellanii is a unicellular eukaryote distributed in a wide range of soil or aquatic environments, either natural or human-made, such as rivers, lakes, drinking water, or swimming pools. Besides its capacity to tr...

  • Article
  • Open Access
3 Citations
1,655 Views
10 Pages

The Role of Ruminants as Sentinel Animals in the Circulation of the West Nile Virus in Tunisia

  • Ahmed Ouni,
  • Hajer Aounallah,
  • Wafa Kammoun Rebai,
  • Francisco Llorente,
  • Walid Chendoul,
  • Walid Hammami,
  • Adel Rhim,
  • Miguel Ángel Jiménez-Clavero,
  • Elisa Pérez-Ramírez and
  • Ali Bouattour
  • + 1 author

Outbreaks of the West Nile Virus (WNV) have increased significantly in recent years in the Mediterranean region, including Tunisia. To understand the risks for animal and human health and to mitigate the impact of future outbreaks, comprehensive vira...

  • Article
  • Open Access
1 Citations
2,109 Views
10 Pages

An Intensive Care Outbreak Caused by Burkholderia cepacia from Bacterial Filters

  • Özlem Aytaç,
  • Elif Seren Tanrıverdi,
  • Ömür Gündağ,
  • Feray Ferda Şenol,
  • Gülden Eser Karlıdağ and
  • Barış Otlu

Background: We report a hospital outbreak caused by Burkholderia cepacia that occurred in 16 patients admitted to intensive care units in Elazığ, Türkiye, between 19 March and 23 April 2024. Methods: The outbreak investigation was init...

  • Review
  • Open Access
1 Citations
3,163 Views
18 Pages

Fusarium graminearum in Wheat—Management Strategies in Central Europe

  • Weronika Giedrojć,
  • Wioletta E. Pluskota and
  • Urszula Wachowska

The main aim of this study was to discuss and compare the threats associated with F. graminearum in wheat production in Poland and in other Central European countries. Wheat is one of the most widely cultivated crops in the world, and pathogens causi...

  • Article
  • Open Access
4 Citations
2,461 Views
12 Pages

Hybrid Capture-Based Sequencing Enables Highly Sensitive Zoonotic Virus Detection Within the One Health Framework

  • Weiya Mao,
  • Jin Wang,
  • Ting Li,
  • Jiani Wu,
  • Jiangrong Wang,
  • Shubo Wen,
  • Jicheng Huang,
  • Yongxia Shi,
  • Kui Zheng and
  • Yali Zhai
  • + 4 authors

Hybrid capture-based target enrichment prior to sequencing has been shown to significantly improve the sensitivity of detection for genetic regions of interest. In the context of One Health relevant pathogen detection, we present a hybrid capture-bas...

  • Article
  • Open Access
1,358 Views
14 Pages

Viral infections have been a severe challenge for global public health, and viral pneumonia is becoming increasingly critical in the post-pandemic era. Observational and basic studies have demonstrated a strong link between host nutrient status and a...

  • Review
  • Open Access
49 Citations
5,719 Views
15 Pages

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, emerged in late 2019 and rapidly evolved into a pandemic around the world. The coronavirus disease (COVID-19) pandemic has dramatically changed the epidemiology...

  • Article
  • Open Access
1,364 Views
25 Pages

Edema disease is a multifactorial infectious disease caused by specific E. coli virotypes possessing fimbriae F18 and toxin Stx2e that cause significant losses in the post-weaning period. The aim of this study was to assess the presence of Stx2e-prod...

  • Article
  • Open Access
1 Citations
2,315 Views
14 Pages

Effect of Green Tea (Camellia sinensis) Extract on Growth Performance, Intestinal Health, and Immune Response of Broiler Chickens During Subclinical Necrotic Enteritis

  • Tunde E. Ogundare,
  • Raveendra R. Kulkarni,
  • Paul C. Omaliko,
  • Odinaka C. Iwuozo,
  • Ikenna G. Enenya,
  • Oluteru E. Orimaye,
  • Safiu A. Suberu,
  • Olusola Jeje and
  • Yewande O. Fasina

This study evaluated the effects of varying levels of dietary green tea extract (GTE) on growth performance, Clostridium perfringens (CP) colonization, and inflammatory responses in broiler chickens during experimental subclinical necrotic enteritis...

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Pathogens - ISSN 2076-0817