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Pathogens, Volume 14, Issue 3

March 2025 - 95 articles

Cover Story: HIV infection cannot be cured due to latently infected cells carrying intact but inactive HIV DNA, making them indistinguishable from uninfected cells. Several strategies have been developed to cure HIV infection, including the reactivation of HIV in latently infected cells, resulting in recognition and death—the “shock and kill” approach. Various latency-reversing agents (LRAs) have been tested in clinical trials. Some were successful in reactivating HIV in vivo and induced detectable changes in the reservoir. Though the technique is not yet curative, these trials prove that latently infected cells can be targeted. In combination with the latest immunomodulatory drugs that aid in killing cells that replicate HIV, new strategies and novel LRAs may be developed in the near future to cure HIV infection. View this paper
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Articles (95)

  • Article
  • Open Access
1,295 Views
20 Pages

Human-papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC) is a distinct disease characterized by unique clinical and molecular features compared to HPV-negative OPSCC. A comprehensive bibliometric analysis of HPV-positi...

  • Article
  • Open Access
2 Citations
1,728 Views
14 Pages

Molecular Evidence of Raccoon Dog (Nyctereutes procyonoides) as a Natural Definitive Host for Several Sarcocystis Species

  • Petras Prakas,
  • Tamara Kalashnikova,
  • Naglis Gudiškis,
  • Donatas Šneideris,
  • Evelina Juozaitytė-Ngugu and
  • Dalius Butkauskas

Sarcocystis parasites infect a wide range of animals, including reptiles, birds, and mammals, and have complex two-host prey–predator life cycle. Sarcocysts are mainly found in the muscles of intermediate hosts, and oocysts sporulate in the int...

  • Article
  • Open Access
3 Citations
2,438 Views
15 Pages

Prevalence and Molecular Characterization of Cryptosporidium Species in Diarrheic Children in Cameroon

  • Bertrand Sone,
  • Lum Abienwi Ambe,
  • Mireille Nguele Ampama,
  • Constance Ajohkoh,
  • Desmond Che,
  • Julien Alban Nguinkal,
  • Anja Taubert,
  • Carlos Hermosilla and
  • Faustin Kamena

Cryptosporidiosis remains a major cause of diarrhea-related childhood death, particularly in developing countries. Although effective anti-retroviral therapy has significantly reduced the cryptosporidiosis burden in western nations, the situation in...

  • Article
  • Open Access
1 Citations
1,537 Views
19 Pages

Human Retinal Organoid Model of Ocular Toxoplasmosis

  • Liam M. Ashander,
  • Grace E. Lidgerwood,
  • Amanda L. Lumsden,
  • João M. Furtado,
  • Alice Pébay and
  • Justine R. Smith

The health burden of ocular toxoplasmosis is substantial, and there is an unmet need for safe and curative anti-microbial drugs. One major barrier to research on new therapeutics is the lack of in vitro human-based models beyond two-dimensional cultu...

  • Review
  • Open Access
8 Citations
7,673 Views
65 Pages

Exploiting Wolbachia as a Tool for Mosquito-Borne Disease Control: Pursuing Efficacy, Safety, and Sustainability

  • Riccardo Moretti,
  • Jue Tao Lim,
  • Alvaro Gil Araujo Ferreira,
  • Luigi Ponti,
  • Marta Giovanetti,
  • Chow Jo Yi,
  • Pranav Tewari,
  • Maria Cholvi,
  • Jacob Crawford and
  • Andrew Paul Gutierrez
  • + 2 authors

Despite the application of control measures, mosquito-borne diseases continue to pose a serious threat to human health. In this context, exploiting Wolbachia, a common symbiotic bacterium in insects, may offer effective solutions to suppress vectors...

  • Article
  • Open Access
3 Citations
2,018 Views
15 Pages

Epidemiological and Clinical Characteristics of Adult RSV Infections: A Retrospective Analysis at University Hospital Center Zagreb (2022–2024)

  • Antonio Perčinić,
  • Tara Vuletić,
  • Nina Lizzul,
  • Andrea Vukić Dugac,
  • Ana Gverić Grginić,
  • Irena Tabain,
  • Dragan Jurić and
  • Ana Budimir

Respiratory syncytial virus (RSV) is a significant cause of respiratory infections in adults, particularly among older adults and individuals with chronic diseases. While traditionally linked to pediatric populations, RSV’s impact on adults, es...

  • Communication
  • Open Access
1 Citations
1,355 Views
10 Pages

Influenza A is a respiratory virus that causes high infection rates and mortality worldwide, particularly affecting high-risk groups such as children, older adults, and individuals with chronic conditions. This retrospective study was conducted at a...

  • Article
  • Open Access
1,108 Views
17 Pages

Impact of Human Body Temperature on Stress Tolerance and Transcriptome of Cronobacter sakazakii

  • Siqi Li,
  • Yuanyuan Wang,
  • Yahao Yang,
  • Xinlu Yu,
  • Jiajia Liu,
  • Meiling Jiang,
  • Jing Zhang,
  • Ge Yun,
  • Yufei Han and
  • Heng Wang
  • + 2 authors

Cronobacter sakazakii is a food-borne pathogen that can thrive in various environments, including the human body. The human body’s physiological temperature exceeds that of the environment (22–30 °C), necessitating adaptations to heat...

  • Article
  • Open Access
1,167 Views
10 Pages

Clinical Characteristics, Neuroimaging Findings and Long-Term Sequelae in Children with Congenital Cytomegalovirus Infection: A Single Centre Study

  • Ivana Valenčak,
  • Lorna Stemberger Marić,
  • Maja Vrdoljak Pažur,
  • Snježana Židovec Lepej,
  • Nenad Šuvak and
  • Goran Tešović

Congenital cytomegalovirus infection is the most common congenital infection worldwide and an important cause of neurodevelopmental delay and sensorineural hearing loss. Neuroimaging represents the best prognostic marker in cCMV infection. The aim of...

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Pathogens - ISSN 2076-0817