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Pathogens, Volume 12, Issue 9

September 2023 - 118 articles

Cover Story: S. aureus exerts pathogenicity and virulence by interacting with extracellular matrix molecules and manipulating hemostasis. The interaction of S. aureus with fibrinogen promotes adhesion to the surface of medical devices. S. aureus coagulases drive fibrin formation, which is essential in inhibiting recognition by opsonins and phagocytosis, and in promoting in biofilm formation. Hypercoagulability and hypofibrinolysis occurring in S. aureus-induced infections, mediated by inflammation-mediated dysregulation of TF and PAI-1, are associated with disseminated intravascular coagulation and multiorgan damage. Induction of fibrinolysis in the plasma of patients with S. aureus bacteremia corresponds to altered biofilm formation and increased IgG-mediated response mediated by the degradation of the fibrin-rich matrix forming the biofilm. View this paper
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Articles (118)

  • Editorial
  • Open Access
1,482 Views
3 Pages

19 September 2023

Climate change, with a special emphasis on global warming, is believed to be a key driver of the accelerated rate of alien species expansion into the Mediterranean Sea basin and, more generally, into all marine and oceanic ecosystems [...]

  • Article
  • Open Access
1 Citations
2,461 Views
14 Pages

19 September 2023

Medical considerations for early diagnosis of tuberculous pericarditis (TBP) include Xpert MTB/RIF Ultra and TB lipoarabinomannan (LAM) antigen (Ag) tests, with immunological status influencing the performance of the latter. An evaluation of the effi...

  • Review
  • Open Access
26 Citations
7,687 Views
20 Pages

Rift Valley Fever Virus—Infection, Pathogenesis and Host Immune Responses

  • Niranjana Nair,
  • Albert D. M. E. Osterhaus,
  • Guus F. Rimmelzwaan and
  • Chittappen Kandiyil Prajeeth

19 September 2023

Rift Valley Fever Virus is a mosquito-borne phlebovirus causing febrile or haemorrhagic illness in ruminants and humans. The virus can prevent the induction of the antiviral interferon response through its NSs proteins. Mutations in the NSs gene may...

  • Article
  • Open Access
4 Citations
2,833 Views
20 Pages

Characterization of Bovine Intraepithelial T Lymphocytes in the Gut

  • Akanksha Hada,
  • Lei Li,
  • Anmol Kandel,
  • Younggeon Jin and
  • Zhengguo Xiao

19 September 2023

Intraepithelial T lymphocytes (T-IELs), which constitute over 50% of the total T lymphocytes in the animal, patrol the mucosal epithelial lining to defend against pathogen invasion while maintaining gut homeostasis. In addition to expressing T cell m...

  • Case Report
  • Open Access
8 Citations
3,759 Views
8 Pages

A Case of Gastroallergic and Intestinal Anisakiasis in Italy: Diagnosis Based on Double Endoscopy and Molecular Identification

  • Stefano D’Amelio,
  • Ilaria Bellini,
  • Claudia Chiovoloni,
  • Cristina Magliocco,
  • Annamaria Pronio,
  • Arianna Di Rocco,
  • Ilaria Pentassuglio,
  • Marco Rosati,
  • Gianluca Russo and
  • Serena Cavallero

18 September 2023

Nematodes of the genus Anisakis (Rhabditida, Anisakidae) are zoonotic fish-borne parasites and cause anisakiasis, a disease with mild to severe acute or chronic gastrointestinal and allergic symptoms and signs. Anisakiasis can potentially lead to mis...

  • Article
  • Open Access
2 Citations
2,395 Views
13 Pages

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

  • Santosh Kumar,
  • Steven Sega,
  • Jamie K. Lynn-Barbe,
  • Dannika L. Harris,
  • Jordan T. Koehn,
  • Debbie C. Crans and
  • Dean C. Crick

18 September 2023

In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semi...

  • Article
  • Open Access
8 Citations
3,399 Views
10 Pages

Efficacy of Single-Dose Praziquantel for the Treatment of Schistosoma mansoni Infections among School Children in Rwanda

  • Joseph Kabatende,
  • Lazare Ntirenganya,
  • Michael Mugisha,
  • Abbie Barry,
  • Eugene Ruberanziza,
  • Emile Bienvenu,
  • Ulf Bergman and
  • Eleni Aklillu

17 September 2023

Preventive chemotherapy with single-dose praziquantel is the WHO-recommended intervention strategy to eliminate schistosomiasis as a public health problem in endemic countries. Surveillance of drugs used in mass drug administration (MDA) programs is...

  • Article
  • Open Access
14 Citations
2,497 Views
12 Pages

Preliminary Results of Feasibility and Acceptability of Self-Collection for Cervical Screening in Italian Women

  • Illari Sechi,
  • Narcisa Muresu,
  • Mariangela V. Puci,
  • Laura Saderi,
  • Arcadia Del Rio,
  • Andrea Cossu,
  • Maria R. Muroni,
  • Santina Castriciano,
  • Marianna Martinelli and
  • Clementina E. Cocuzza
  • + 2 authors

17 September 2023

Background: Given the diagnostic accuracy of HPV-DNA tests in terms of self-collected samples, in order to implement self-sampling in cervical screening programs, the standardization of the pre-analytical phase, including decisions concerning the cho...

  • Article
  • Open Access
4 Citations
2,927 Views
14 Pages

Alteration of the Chicken Upper Respiratory Microbiota, Following H9N2 Avian Influenza Virus Infection

  • Tara Davis,
  • Dagmara Bialy,
  • Joy Leng,
  • Roberto La Ragione,
  • Holly Shelton and
  • Klaudia Chrzastek

16 September 2023

Several studies have highlighted the importance of the gut microbiota in developing immunity against viral infections in chickens. We have previously shown that H9N2 avian influenza A virus (AIV) infection retards the diversity of the natural colon-a...

  • Review
  • Open Access
78 Citations
22,555 Views
26 Pages

16 September 2023

Leptospirosis is a zoonotic disease of global importance with significant morbidity and mortality. However, the disease is frequently overlooked and underdiagnosed, leading to uncertainty of the true scale and severity of the disease. A neglected tro...

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Pathogens - ISSN 2076-0817