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Pathogens, Volume 11, Issue 1

January 2022 - 109 articles

Cover Story: Helicobacter pylori is a gastric pathogen that exploits multiple host signaling pathways, leading to the disruption of key cell functions. Two bacterial virulence factors play important roles in this scenario, the vacuolating cytotoxin VacA and the translocated effector protein CagA of the cag type IV secretion system (T4SS). Specifically, by overruling the phosphorylation status of cortactin, H. pylori alternates the activity of molecular interaction partners of this important protein, thereby manipulating the performance of cytoskeletal rearrangements, endosomal trafficking, and cell movement. Here, we found that cortactin is necessary for the effective induction of T4SS- and CagA-dependent AGS cell movement and elongation but is dispensable for VacA uptake and formation of VacA-dependent vacuole formation and cell apoptosis. View this paper.
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Articles (109)

  • Review
  • Open Access
41 Citations
7,625 Views
17 Pages

Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential

  • Fanzhi Kong,
  • Qiuhong Wang,
  • Scott P. Kenney,
  • Kwonil Jung,
  • Anastasia N. Vlasova and
  • Linda J. Saif

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus of swine that causes acute diarrhoea, vomiting, dehydration and mortality in seronegative neonatal piglets. PDCoV was first reported in Hong Kong in 2012 and its etiological...

  • Article
  • Open Access
17 Citations
4,335 Views
13 Pages

Odontogenic Cervicofacial Necrotizing Fasciitis: Microbiological Characterization and Management of Four Clinical Cases

  • Sebastian Böttger,
  • Silke Zechel-Gran,
  • Daniel Schmermund,
  • Philipp Streckbein,
  • Jan-Falco Wilbrand,
  • Michael Knitschke,
  • Jörn Pons-Kühnemann,
  • Torsten Hain,
  • Markus Weigel and
  • Can Imirzalioglu
  • + 3 authors

Necrotizing fasciitis of the head and neck is a rare, very severe disease, which, in most cases, originates from odontogenic infections and frequently ends with the death of the patient. Rapid surgical intervention in combination with a preferably pa...

  • Article
  • Open Access
5 Citations
3,701 Views
10 Pages

Quantitative Risk Assessment of African Swine Fever Introduction into Spain by Legal Import of Live Pigs

  • Carolina Muñoz-Pérez,
  • Jaime Bosch,
  • Satoshi Ito,
  • Marta Martínez-Avilés and
  • José Manuel Sánchez-Vizcaíno

African swine fever (ASF) is a devastating infectious disease of pigs that is threatening the global swine industry at present. The current spread of ASF in Europe and its recent incursion into Germany pose a serious risk to Spain, one of the world&r...

  • Review
  • Open Access
17 Citations
4,807 Views
12 Pages

Vaccines for Mycoplasma Diseases of Small Ruminants: A Neglected Area of Research

  • Katarzyna Dudek,
  • Umit Sevimli,
  • Sergio Migliore,
  • Amirreza Jafarizadeh,
  • Guido R. Loria and
  • Robin A. J. Nicholas

Mycoplasmas cause some of the most economically important diseases of sheep and goats, including diseases listed by the World Organisation for Animal Health (OIE) such as contagious caprine pleuropneumonia (CCPP) and contagious agalactia (CA). Other...

  • Review
  • Open Access
19 Citations
5,812 Views
14 Pages

Arboviral Disease Outbreaks in the Pacific Islands Countries and Areas, 2014 to 2020: A Systematic Literature and Document Review

  • Rosie J. Matthews,
  • Ishani Kaluthotage,
  • Tanya L. Russell,
  • Tessa B. Knox,
  • Paul F. Horwood and
  • Adam T. Craig

Arthropod-borne diseases pose a significant public health threat, accounting for greater than 17% of infectious disease cases and 1 million deaths annually. Across Pacific Island countries and areas (PICs), outbreaks of dengue, chikungunya, and Zika...

  • Article
  • Open Access
12 Citations
3,151 Views
11 Pages

Amphotericin B Polymer Nanoparticles Show Efficacy against Candida Species Biofilms

  • Abdulghani Alakkad,
  • Paul Stapleton,
  • Corinna Schlosser,
  • Sudaxshina Murdan,
  • Uchechukwu Odunze,
  • Andreas Schatzlein and
  • Ijeoma F. Uchegbu

Purpose: Chronic infections of Candida albicans are characterised by the embedding of budding and entwined filamentous fungal cells into biofilms. The biofilms are refractory to many drugs and Candida biofilms are associated with ocular fungal infect...

  • Article
  • Open Access
15 Citations
3,392 Views
15 Pages

Salmonella causes significant economic loss to the poultry industry and represents a real threat to human health. The region of difference 21 (ROD21) pathogenicity island removal is a genetic mechanism by which Salmonellaenteritidis (SE) invades the...

  • Article
  • Open Access
3 Citations
3,210 Views
11 Pages

Rabies Vaccination in Dogs in Laos: Owner Knowledge and Serological Status of Dogs

  • Lovisa Velander,
  • Johanna Fogelberg,
  • Vannaphone Putthana,
  • Amphone Keosengthong and
  • Johanna Frida Lindahl

Rabies is an infectious disease which is virtually 100% fatal. Humans are most often infected through the bite of an infected dog, and most cases could be prevented by vaccinating dogs. However, vaccination coverage is insufficient in most countries...

  • Article
  • Open Access
8 Citations
3,240 Views
13 Pages

Based on the ecological plaque hypothesis, suppressing opportunistic pathogens within biofilms, rather than killing microbes indiscriminately, could be a biofilm control strategy for managing dental caries. The present study aimed to evaluate the eff...

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Pathogens - ISSN 2076-0817Creative Common CC BY license