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Journal of Personalized Medicine, Volume 13, Issue 12

December 2023 - 103 articles

Cover Story:

Sepsis is a medical emergency that requires urgent intervention, but is commonly misdiagnosed or has delayed diagnosis due to both a clinical presentation that is often nonspecific and lack of a definitive diagnostic test.  Providers are often tasked with making an empiric diagnosis and initiating treatment with incomplete evidence using only initial presentation and history as inputs. This can lead to a sepsis diagnosis being largely dependent upon clinical judgment, which can differ substantially between providers.

In this manuscript, we aim to explore two case presentations to fully characterize and evaluate the extent of variability in expert clinician assessments of sepsis prior to the availability of a sepsis diagnostic and discuss potential ways a specific rapid host response test might be used to increase consistency in the approach to sepsis diagnosis. View this paper

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Articles (103)

  • Article
  • Open Access
2 Citations
3,246 Views
15 Pages

Effect of Anterioposterior Weight-Shift Training with Visual Biofeedback in Patients with Step Length Asymmetry after Subacute Stroke

  • Yea Jin Jo,
  • Dae Hyun Kim,
  • Seeun Kim,
  • Jung Hoon Kim,
  • Jong Hyun Choi,
  • Jong Bum Park,
  • Yoon Su Baek,
  • Yoon Ghil Park and
  • Deog Young Kim

18 December 2023

Step length asymmetry is a characteristic feature of gait in post-stroke patients. A novel anterioposterior weight-shift training method with visual biofeedback (AP training) was developed to improve the forward progression of the trunk. This study a...

  • Article
  • Open Access
2 Citations
2,785 Views
12 Pages

Prevalent Variants in the LDLR Gene Impair Responsiveness to Rosuvastatin among Family Members of Patients with Premature Myocardial Infarction

  • Nguyen Trung Kien,
  • Tran Tin Nghia,
  • Nguyen Minh Hoang,
  • Tran Nguyen Trong Phu,
  • Pham Thi Ngoc Nga,
  • Ha Thi Thao Mai and
  • J. Luis Espinoza

18 December 2023

Background: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-c) from birth. About 85% of all FH cases are caused by pathogenic variants in the LDLR gene. In...

  • Article
  • Open Access
2 Citations
2,048 Views
10 Pages

Significance of S100B Protein as a Rapid Diagnostic Tool in Emergency Departments for Traumatic Brain Injury Patients

  • Rakesh Jalali,
  • Izabela Godlewska,
  • Magdalena Fadrowska-Szleper,
  • Agata Pypkowska,
  • Adam Kern,
  • Jacek Bil,
  • Joanna Manta and
  • Jerzy Romaszko

18 December 2023

Traumatic brain injuries (TBIs) are not only the leading cause of death among people below 44 years of age, but also one of the biggest diagnostic challenges in the emergency set up. We believe that the use of serum biomarkers in diagnosis can help t...

  • Article
  • Open Access
5 Citations
5,546 Views
10 Pages

Relationship and New Prospectives in Joint Hypermobility in Children with Autism Spectrum Disorder: Preliminary Data

  • Domenico Marco Romeo,
  • Marianna Moro,
  • Mariangela Pezone,
  • Ilaria Venezia,
  • Federica Mirra,
  • Margherita De Biase,
  • Agnese Polo,
  • Ida Turrini,
  • Maria Rosaria Lala and
  • Chiara Velli
  • + 4 authors

18 December 2023

Autism spectrum disorder (ASD) and joint hypermobility (JH) are considered two different etiological and clinical entities that most often appear in childhood. Despite growing increased research showing a co-occurrence for both conditions, a link bet...

  • Article
  • Open Access
3,560 Views
10 Pages

Association between Conflicts of Interest Disclosure and Quality of Clinical Practice Guidelines in Japan: A Meta-Epidemiological Study

  • Norio Yamamoto,
  • Akihiko Ozaki,
  • Shunsuke Taito,
  • Takashi Ariie,
  • Hidehiro Someko,
  • Hiroaki Saito,
  • Tetsuya Tanimoto and
  • Yuki Kataoka

17 December 2023

Accurate disclosure of financial conflicts of interest (COI) among clinical practice guideline (CPG) developers is critical to ensure the quality of CPGs. However, there is limited evidence on the impact of underreporting COIs on the quality of CPGs....

  • Article
  • Open Access
1 Citations
1,744 Views
14 Pages

Analysis of the Larissa Heart Failure Risk Score: Predictive Value in 9207 Patients Hospitalized for Heart Failure from a Single Center

  • Andrew Xanthopoulos,
  • John Skoularigis,
  • Alexandros Briasoulis,
  • Dimitrios E. Magouliotis,
  • Alex Zajichek,
  • Alex Milinovich,
  • Michael W. Kattan,
  • Filippos Triposkiadis and
  • Randall C. Starling

17 December 2023

Early risk stratification is of outmost clinical importance in hospitalized patients with heart failure (HHF). We examined the predictive value of the Larissa Heart Failure Risk Score (LHFRS) in a large population of HHF patients from the Cleveland C...

  • Article
  • Open Access
1,770 Views
13 Pages

17 December 2023

Neurofibroma (NF) is a benign tumor in the peripheral nervous system, but it can infiltrate around structures and cause functional impairment and disfigurement. We incidentally found that the expression of CD16a (Fc gamma receptor IIIA) was increased...

  • Article
  • Open Access
2 Citations
2,066 Views
12 Pages

Patient Adherence to Written Instructions following Complete Allergological Evaluation for Suspected Beta-Lactam Allergy: A Tertiary Hospital Study in Greece

  • Michael Makris,
  • Niki Papapostolou,
  • Maria Pasali,
  • Xenofon Aggelidis,
  • Caterina Chliva and
  • Alexander C. Katoulis

17 December 2023

Background: Beta-lactam (BL) antibiotics are among the most prescribed groups of drugs worldwide and have been implicated in a variety of allergic reactions. There is a paucity of literature regarding patient adherence to prescribed instructions foll...

  • Article
  • Open Access
4 Citations
3,258 Views
13 Pages

Correlation between Topographic Vessel Density and Retinal Thickness Changes in Patients with Diabetic Macular Edema Treated with Anti-VEGF Therapy: Is It a Suitable OCTA Biomarker?

  • Juan Santamaría,
  • José María Caminal,
  • Estefanía Cobos,
  • Marc Biarnes,
  • Ramon Rodriguez-Leor,
  • Rahul Morwani,
  • Manel García-Mendieta,
  • Daniel Lorenzo,
  • Pere García-Bru and
  • Luis Arias

16 December 2023

The objective of this study was to determine the correlation between topographic vessel density (VD) and retinal thickness (RT) reductions induced by vascular endothelial growth factor inhibitors (anti-VEGF) in patients with diabetic macular edema (D...

  • Article
  • Open Access
1 Citations
1,807 Views
10 Pages

Influence of Otolaryngological Subspecialties on Perception of Transoral Robotic Surgery: An International YO-IFOS Survey

  • Antonino Maniaci,
  • Carlos Chiesa Estomba,
  • Nicolas Fakhry,
  • Luigi Angelo Vaira,
  • Marc Remacle,
  • Giovanni Cammaroto,
  • Maria Rosaria Barillari,
  • Giannicola Iannella,
  • Miguel Mayo-Yanez and
  • Alberto Maria Saibene
  • + 12 authors

15 December 2023

Background: To investigate perception, adoption, and awareness on the part of otolaryngology and head and neck surgeons (OTO-HNS) of transoral robotic surgery (TORS). Methods: Several items assessed: awareness/perception; access to TORS; training; in...

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J. Pers. Med. - ISSN 2075-4426