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Journal of Personalized Medicine, Volume 13, Issue 12

December 2023 - 103 articles

Cover Story:

Sepsis is a medical emergency that requires urgent intervention, but is commonly misdiagnosed or has delayed diagnosis due to both a clinical presentation that is often nonspecific and lack of a definitive diagnostic test.  Providers are often tasked with making an empiric diagnosis and initiating treatment with incomplete evidence using only initial presentation and history as inputs. This can lead to a sepsis diagnosis being largely dependent upon clinical judgment, which can differ substantially between providers.

In this manuscript, we aim to explore two case presentations to fully characterize and evaluate the extent of variability in expert clinician assessments of sepsis prior to the availability of a sepsis diagnostic and discuss potential ways a specific rapid host response test might be used to increase consistency in the approach to sepsis diagnosis. View this paper

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Articles (103)

  • Review
  • Open Access
3 Citations
3,620 Views
17 Pages

Evaluation and Management of Sudden Death Risk in Repaired Tetralogy of Fallot

  • Eiad Habib,
  • Komandoor Srivasthan and
  • Hicham El Masry

15 December 2023

Although substantial progress has been made to prevent sudden cardiac death in repaired tetralogy of Fallot patients, ventricular arrhythmia and sudden death continue to be major causes of morbidity and mortality in these patients. Greater survival i...

  • Article
  • Open Access
5 Citations
2,777 Views
17 Pages

Effects of Electromyographic Biofeedback-Assisted Exercise on Functional Recovery and Quality of Life in Patients after Total Hip Arthroplasty: A Randomized Controlled Trial

  • Tomislav Kokic,
  • Roman Pavic,
  • Matko Vuksanic,
  • Stjepan Jelica,
  • Antun Sumanovac,
  • Tihomir Banic,
  • Helena Ostović and
  • Iva Sklempe Kokic

15 December 2023

The goal of the trial was to examine the effects of adding electromyographic biofeedback (EMG-BF) to the conventional program of physiotherapy after total hip arthroplasty (THA) on functional recovery and quality of life. The trial was designed as a...

  • Article
  • Open Access
6 Citations
2,444 Views
14 Pages

From Data to Insights: Machine Learning Empowers Prognostic Biomarker Prediction in Autism

  • Ecmel Mehmetbeyoglu,
  • Abdulkerim Duman,
  • Serpil Taheri,
  • Yusuf Ozkul and
  • Minoo Rassoulzadegan

15 December 2023

Autism Spectrum Disorder (ASD) poses significant challenges to society and science due to its impact on communication, social interaction, and repetitive behavior patterns in affected children. The Autism and Developmental Disabilities Monitoring (AD...

  • Article
  • Open Access
2 Citations
3,118 Views
19 Pages

Unmasking the Silent Threat: Periodontal Health’s Impact on COPD Severity and Hospitalization

  • Anitha Subbappa,
  • Komarla Sundararaja Lokesh,
  • Sindaghatta Krishnarao Chaya,
  • Mohammed Kaleem Ullah,
  • Jayaraj Biligere Siddaiah,
  • Nandlal Bhojraj and
  • Padukudru Anand Mahesh

15 December 2023

Objective: This study investigated the relationship between chronic obstructive pulmonary disease (COPD) and periodontitis, focusing on how periodontal health impacts COPD airflow limitation, exacerbations, and hospitalization. Background: Periodonti...

  • Case Report
  • Open Access
1,665 Views
13 Pages

The Arterial Axis Lesions in Proximal Humeral Fractures—Case Report and Literature Review

  • Cosmin Ioan Faur,
  • Razvan Nitu,
  • Simona-Alina Abu-Awwad,
  • Cristina Tudoran and
  • Ahmed Abu-Awwad

14 December 2023

Background: This comprehensive review delves into the nuanced domain of arterial axis lesions associated with proximal humeral fractures, elucidating the intricate interplay between fracture patterns and vascular compromise. Proximal humeral fracture...

  • Case Report
  • Open Access
6 Citations
4,403 Views
10 Pages

VRAM Flap for Pelvic Floor Reconstruction after Pelvic Exenteration and Abdominoperineal Excision

  • Ionut Flaviu Faur,
  • Adelina Clim,
  • Amadeus Dobrescu,
  • Catalin Prodan,
  • Rami Hajjar,
  • Paul Pasca,
  • Marco Capitanio,
  • Cristi Tarta,
  • Alexandru Isaic and
  • George Noditi
  • + 4 authors

14 December 2023

Due to the still large number of patients diagnosed with pelvic neoplasms (colorectal, gynecological, and urological) in advanced stages right from the initial diagnosis, surgery represents the mainstay of treatment, often implying wide, eventually m...

  • Article
  • Open Access
10 Citations
2,663 Views
15 Pages

Biomarkers and Strain Echocardiography for the Detection of Subclinical Cardiotoxicity in Breast Cancer Patients Receiving Anthracyclines

  • Aditi A. Bhagat,
  • Andreas P. Kalogeropoulos,
  • Lea Baer,
  • Matthew Lacey,
  • Smadar Kort,
  • Hal A. Skopicki,
  • Javed Butler and
  • Michelle Weisfelner Bloom

14 December 2023

The optimal surveillance and management strategies for breast cancer patients receiving anthracycline therapy are limited by our incomplete understanding of the role of biomarkers heralding the onset of cardiotoxicity. The purpose of this study was t...

  • Article
  • Open Access
8 Citations
3,070 Views
18 Pages

A New Approach to Virtual Occlusion in Orthognathic Surgery Planning Using Mixed Reality—A Technical Note and Review of the Literature

  • Max Wilkat,
  • Shufang Liu,
  • Michael Schwerter,
  • Felix Schrader,
  • Leonardo Saigo,
  • Nadia Karnatz,
  • Norbert R. Kübler and
  • Majeed Rana

14 December 2023

Orthognathic surgery plays a vital role in correcting various skeletal discrepancies of the maxillofacial region. Achieving optimal occlusion is a fundamental aspect of orthognathic surgery planning, as it directly influences postoperative outcomes a...

  • Case Report
  • Open Access
7 Citations
2,353 Views
10 Pages

Cochlear Implantation in Patients with Bilateral Sudden Sensorineural Hearing Loss after COVID-19 Infection

  • Nenad Arsović,
  • Marija Jovanović,
  • Snežana Babac,
  • Ljiljana Čvorović,
  • Nemanja Radivojević and
  • Konstantin Arsović

14 December 2023

COVID-19 infection is associated with a variety of neurological manifestations. Since the inner ear is vulnerable to viruses, sensorineural hearing loss (SNHL) has been reported to occur following SARS-CoV-2 infection. We present here two cases of pr...

  • Article
  • Open Access
5 Citations
2,316 Views
13 Pages

An Assessment of the Knowledge and Perceptions of Precision Medicine (PM) in the Rwandan Healthcare Setting

  • Clarisse Musanabaganwa,
  • Hinda Ruton,
  • Deogratias Ruhangaza,
  • Nicaise Nsabimana,
  • Emmanuel Kayitare,
  • Thierry Zawadi Muvunyi,
  • Muhammed Semakula,
  • Faustin Ntirenganya,
  • Emile Musoni and
  • Jules Ndoli
  • + 11 authors

14 December 2023

Introduction: Precision medicine (PM) or personalized medicine is an innovative approach that aims to tailor disease prevention and treatment to consider the differences in people’s genes, environments, and lifestyles. Although many efforts hav...

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J. Pers. Med. - ISSN 2075-4426