You are currently viewing a new version of our website. To view the old version click .

Journal of Personalized Medicine, Volume 11, Issue 6

June 2021 - 149 articles

Cover Story: Venetoclax is a highly selective and effective B-cell lymphoma-2 (BCL2) inhibitor, with a unique ability to reinstate the apoptotic potential of cancer cells. With its full potential yet to be explored and a promising risk–benefit profile, it has proven to be paradigm shifting in a range of haematological malignancies. Despite this, venetoclax is not curative, and treatment is inevitably hamstrung by disease relapse over time. Ongoing research continues to shed light on the complex genomic and epigenomic environment that gives rise to disease resistance. Understanding these mechanisms further will aid rational drug combinations to improve long-term outcomes in patients on venetoclax therapy. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (149)

  • Article
  • Open Access
6 Citations
2,629 Views
9 Pages

A Personalized Approach to Percutaneous Coronary Interventions in the Left Main Coronary Artery—Is the Female Gender Associated with Worse Outcomes?

  • Marta Kałużna-Oleksy,
  • Wojciech Jan Skorupski,
  • Marek Grygier,
  • Aleksander Araszkiewicz,
  • Włodzimierz Skorupski,
  • Stefan Grajek,
  • Przemysław Mitkowski,
  • Małgorzata Pyda and
  • Maciej Lesiak

20 June 2021

There is still controversy whether the female gender is associated with worse outcomes after the percutaneous coronary intervention within the left main (LM PCI). This study aimed to examine gender-based differences in real-life LM PCI patients and p...

  • Communication
  • Open Access
17 Citations
4,253 Views
7 Pages

Antibody Response Following a Two-Dose mRNA Vaccination Regimen, in Health Care Workers of a Tertiary Hospital in Athens, Greece

  • Elissavet Kontou,
  • Kyriaki Ranellou,
  • Dimitrios Zoulas,
  • Anastasia Bletsa,
  • Eirini Rompola,
  • Evangelia-Theophano Piperaki,
  • Nikolaos Athanasiou,
  • Kleio Ampelakiotou,
  • Maria Pratikaki and
  • Christina Stergiopoulou
  • + 4 authors

19 June 2021

We analyzed the antibody responses of 564 hospital workers in Athens, Greece, after vaccination with two doses of the BNT162b2 (Comirnaty®; BioNTech and Pfizer) mRNA COVID-19 vaccine. A greater antibody increase was observed in women, younger age gro...

  • Article
  • Open Access
9 Citations
3,943 Views
11 Pages

A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status

  • Chun-Hao Chen,
  • Yen-Pei Lu,
  • An-Ting Lee,
  • Chun-Wu Tung,
  • Yuan-Hsiung Tsai,
  • Hsin-Pei Tsay,
  • Chih-Ting Lin and
  • Jen-Tsung Yang

19 June 2021

The evaluation of fluid status can save adults from life-threatening conditions, but the current methods are invasive or time-consuming. Therefore, we developed a portable device for measuring salivary conductivity. This prospective observational stu...

  • Feature Paper
  • Review
  • Open Access
472 Citations
17,624 Views
27 Pages

Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

  • Md Abdus Subhan,
  • Satya Siva Kishan Yalamarty,
  • Nina Filipczak,
  • Farzana Parveen and
  • Vladimir P. Torchilin

18 June 2021

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy administered intravenously escape renal clearance, are unable to pene...

  • Article
  • Open Access
4 Citations
3,509 Views
12 Pages

Pediatric Oncologists’ Experiences Returning and Incorporating Genomic Sequencing Results into Cancer Care

  • Rebecca L. Hsu,
  • Amanda M. Gutierrez,
  • Sophie K. Schellhammer,
  • Jill O. Robinson,
  • Sarah Scollon,
  • Richard L. Street,
  • Alyssa N. Salisbury,
  • Stacey Pereira,
  • Sharon E. Plon and
  • Janet Malek
  • + 2 authors

18 June 2021

Pediatric oncologists’ perspectives around returning and incorporating tumor and germline genomic sequencing (GS) results into cancer care are not well-described. To inform optimization of cancer genomics communication, we assessed oncologists’ exper...

  • Feature Paper
  • Article
  • Open Access
10 Citations
5,473 Views
12 Pages

Individual Revision Knee Arthroplasty Is a Safe Limb Salvage Procedure

  • Peter Savov,
  • Lars-Rene Tuecking,
  • Henning Windhagen and
  • Max Ettinger

18 June 2021

Introduction: Revision total knee arthroplasty after multiple pre-surgeries is challenging. Due to severe bone defects, standard implants for metaphyseal and diaphyseal anchoring may no longer be suitable. The primary aim of this case series is to ev...

  • Article
  • Open Access
14 Citations
3,984 Views
15 Pages

Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis

  • Noelia Márquez Pete,
  • María del Mar Maldonado Montoro,
  • Cristina Pérez Ramírez,
  • Fernando Martínez Martínez,
  • Juan Enrique Martínez de la Plata,
  • Abdelali Daddaoua and
  • Alberto Jiménez Morales

18 June 2021

Abatacept (ABA) is an immunosuppressant indicated for treatment of rheumatoid arthritis (RA). Effectiveness might be influenced by clinical RA variants and single-nucleotide polymorphisms (SNPs) in genes encoding protein FCGR2A (His131Arg) and FCGR3A...

  • Article
  • Open Access
15 Citations
3,741 Views
13 Pages

18 June 2021

The aim of this study was to evaluate the usefulness of a personalized 3D-printed thyroid model that characterizes a patient’s individual thyroid lesion. The randomized controlled prospective clinical trial (KCT0005069) was designed. Fifty-three of t...

  • Article
  • Open Access
10 Citations
4,192 Views
13 Pages

Detection of Aberrant Glycosylation of Serum Haptoglobin for Gastric Cancer Diagnosis Using a Middle-Up-Down Glycoproteome Platform

  • Seunghyup Jeong,
  • Unyong Kim,
  • Myung Jin Oh,
  • Jihyeon Nam,
  • Se Hoon Park,
  • Yoon Jin Choi,
  • Dong Ho Lee,
  • Jaehan Kim and
  • Hyun Joo An

18 June 2021

Gastric cancer is a frequently occurring cancer and is the leading cause of cancer-related deaths. Recent studies have shown that aberrant glycosylation of serum haptoglobin is closely related to gastric cancer and has enormous potential for use in d...

  • Article
  • Open Access
13 Citations
4,469 Views
21 Pages

Efficient Genetic Safety Switches for Future Application of iPSC-Derived Cell Transplants

  • Julia Dahlke,
  • Juliane W. Schott,
  • Philippe Vollmer Barbosa,
  • Denise Klatt,
  • Anton Selich,
  • Nico Lachmann,
  • Michael Morgan,
  • Thomas Moritz and
  • Axel Schambach

17 June 2021

Induced pluripotent stem cell (iPSC)-derived cell products hold great promise as a potential cell source in personalized medicine. As concerns about the potential risk of graft-related severe adverse events, such as tumor formation from residual plur...

of 15

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
J. Pers. Med. - ISSN 2075-4426