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Diagnostics, Volume 13, Issue 8

2023 April-2 - 145 articles

Cover Story: The biochemical confirmation of hypercortisolism is complicated by the overlap with non-autonomous conditions and the practical difficulties of cortisol measurement. This limited narrative review focuses on the laboratory confirmation of hypercortisolism in patients with Cushing syndrome. Although analytically less specific, immunoassays remain cheap, quick, and mostly reliable. Cortisol metabolism however affects patient preparation, specimen selection (e.g., consideration of free cortisol, or late-night specimens and cessation of drugs), and method selection (e.g., mass spectrometry if abnormal metabolites are present). Urine steroid profiles and salivary cortisone may have a role in future guidelines as technology and costs improve. View this paper
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Articles (145)

  • Article
  • Open Access
7 Citations
3,606 Views
10 Pages

The Stability of the Anti-Müllerian Hormone in Serum and Plasma Samples under Various Preanalytical Conditions

  • Radana Vrzáková,
  • Václav Šimánek,
  • Ondřej Topolčan,
  • Vladimír Vurm,
  • David Slouka and
  • Radek Kučera

The anti-Müllerian hormone (AMH) is a glycoprotein that plays an important role in prenatal sex differentiation. It is used as a biomarker in polycystic ovary syndrome (PCOS) diagnostics, as well as for estimating an individual’s ovarian reserve and...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
8 Citations
2,711 Views
14 Pages

Approximately 32–42% of very preterm infants develop minor motor abnormalities. Earlier diagnosis soon after birth is urgently needed because the first two years of life represent a critical window of opportunity for early neuroplasticity in in...

(This article belongs to the Special Issue Artificial Intelligence for Magnetic Resonance Imaging)
  • Review
  • Open Access
16 Citations
4,360 Views
14 Pages

Crohn’s disease (CD) is a chronic inflammatory disorder characterized by a transmural inflammation that may involve any part of the gastrointestinal tract. An evaluation of small bowel involvement, allowing recognition of disease extent and sev...

(This article belongs to the Special Issue IBD: New Trends in Diagnosis and Management)
  • Article
  • Open Access
127 Citations
11,522 Views
21 Pages

Polycystic Ovary Syndrome Detection Machine Learning Model Based on Optimized Feature Selection and Explainable Artificial Intelligence

  • Hela Elmannai,
  • Nora El-Rashidy,
  • Ibrahim Mashal,
  • Manal Abdullah Alohali,
  • Sara Farag,
  • Shaker El-Sappagh and
  • Hager Saleh

Polycystic ovary syndrome (PCOS) has been classified as a severe health problem common among women globally. Early detection and treatment of PCOS reduce the possibility of long-term complications, such as increasing the chances of developing type 2...

(This article belongs to the Special Issue Explainable Artificial Intelligence for Trustworthy Machine Learning and Deep Learning Models in Healthcare)
  • Article
  • Open Access
8 Citations
3,066 Views
11 Pages

The Prevalence of Multidrug-Resistant Enterobacteriaceae among Neonates in Kuwait

  • Rehab Zafer Alajmi,
  • Wadha Ahmed Alfouzan and
  • Abu Salim Mustafa

Increasing numbers of neonates with serious bacterial infections, due to resistant bacteria, are associated with considerable morbidity and mortality rates. The aim of this study was to evaluate the prevalence of drug-resistant Enterobacteriaceae in...

(This article belongs to the Special Issue Diagnosis of Neonatal Diseases)
  • Review
  • Open Access
7 Citations
3,719 Views
23 Pages

Myocardial Recovery

  • Nikolaos Chrysakis,
  • Andrew Xanthopoulos,
  • Dimitrios Magouliotis,
  • Randall C. Starling,
  • Stavros G. Drakos,
  • Filippos Triposkiadis and
  • John Skoularigis

In this paper, the feasibility of myocardial recovery is analyzed through a literature review. First, the phenomena of remodeling and reverse remodeling are analyzed, approached through the physics of elastic bodies, and the terms myocardial depressi...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
67 Citations
6,791 Views
16 Pages

A Transfer Learning Approach for Clinical Detection Support of Monkeypox Skin Lesions

  • Maram Fahaad Almufareh,
  • Samabia Tehsin,
  • Mamoona Humayun and
  • Sumaira Kausar

Monkeypox (MPX) is a disease caused by monkeypox virus (MPXV). It is a contagious disease and has associated symptoms of skin lesions, rashes, fever, and respiratory distress lymph swelling along with numerous neurological distresses. This can be a d...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Review
  • Open Access
11 Citations
5,705 Views
24 Pages

Craniovertebral Junction Instability after Oncological Resection: A Narrative Review

  • Malte Ottenhausen,
  • Elena Greco,
  • Giacomo Bertolini,
  • Andrea Gerosa,
  • Salvatore Ippolito,
  • Erik H. Middlebrooks,
  • Graziano Serrao,
  • Maria Grazia Bruzzone,
  • Francesco Costa and
  • Emanuele La Corte
  • + 1 author

The craniovertebral junction (CVJ) is a complex transition area between the skull and cervical spine. Pathologies such as chordoma, chondrosarcoma and aneurysmal bone cysts may be encountered in this anatomical area and may predispose individuals to...

(This article belongs to the Special Issue Assessment and Management of Instability in Spinal Tumors)
  • Article
  • Open Access
2,555 Views
10 Pages

Analysis of Corneal Deformation in Paediatric Patients Affected by Maturity Onset Diabetes of the Young Type 2

  • Michele Lanza,
  • Enza Mozzillo,
  • Rosa Boccia,
  • Ludovica Fedi,
  • Francesca Di Candia,
  • Nadia Tinto,
  • Paolo Melillo,
  • Francesca Simonelli and
  • Adriana Franzese

Background: To evaluate corneal deformation in Maturity Onset Diabetes of the Young type 2 (MODY2), paediatric subjects were analysed using a Scheimpflug-based device. The purpose of this analysis was to find new biomarkers for MODY2 disease and to g...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Systematic Review
  • Open Access
4 Citations
4,416 Views
13 Pages

Effectiveness of Using the FreeStyle Libre® System for Monitoring Blood Glucose during the COVID-19 Pandemic in Diabetic Individuals: Systematic Review

  • Luelia Teles Jaques-Albuquerque,
  • Elzi dos Anjos-Martins,
  • Luiza Torres-Nunes,
  • Ana Gabriellie Valério-Penha,
  • Ana Carolina Coelho-Oliveira,
  • Viviani Lopes da Silva Sarandy,
  • Aline Reis-Silva,
  • Adérito Seixas,
  • Mario Bernardo-Filho and
  • Danúbia Cunha de Sá-Caputo
  • + 1 author

Background: Artificial Intelligence (AI) is an area of computer science/engineering that is aiming to spread technological systems. The COVID-19 pandemic caused economic and public health turbulence around the world. Among the many possibilities for...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
8 Citations
2,819 Views
10 Pages

Comparison of Diagnostic Yield and Safety of Serial Pancreatic Juice Aspiration Cytologic Examination (SPACE) with Different Indications

  • Tatsunori Satoh,
  • Shinya Kawaguchi,
  • Shodai Takeda,
  • Yuya Ishiguro,
  • Kazuhisa Asahara,
  • Shuzo Terada,
  • Shinya Endo,
  • Naofumi Shirane,
  • Hideyuki Kanemoto and
  • Kazuya Ohno

We assessed whether there are differences in the diagnostic yield and safety of serial pancreatic juice aspiration cytologic examination (SPACE) among different indications. We retrospectively analyzed 226 patients who underwent SPACE. They were clas...

(This article belongs to the Special Issue Early Diagnosis of Pancreatic Cancer 2022–2023)
  • Article
  • Open Access
6 Citations
5,910 Views
12 Pages

Tuberculosis (TB) is one of the leading causes of infectious mortality from a single infectious agent, Mycobacterium tuberculosis (MTB). This study evaluated the performance of the newly developed BZ TB/NTM NALF assay, which integrated loop-mediated...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
11 Citations
8,199 Views
13 Pages

Patello-Femoral Pain Syndrome: Magnetic Resonance Imaging versus Ultrasound

  • Patrizia Pacini,
  • Milvia Martino,
  • Luca Giuliani,
  • Gabriele Santilli,
  • Francesco Agostini,
  • Giovanni Del Gaudio,
  • Andrea Bernetti,
  • Massimiliano Mangone,
  • Marco Paoloni and
  • Vito Cantisani
  • + 4 authors

Background: Magnetic Resonance Imaging (MRI) and Ultrasound (US) in combination with clinical data could contribute to the diagnosis, staging and follow-up of Patello-Femoral Syndrome (PFS), which often overlaps with other pathologies of the knee. Pu...

(This article belongs to the Special Issue Advanced MRI in Clinical Diagnosis)
  • Brief Report
  • Open Access
7 Citations
2,458 Views
8 Pages

Multiparametric Skin Assessment in a Monocentric Cohort of Systemic Sclerosis Patients: Is There a Role for Ultra-High Frequency Ultrasound?

  • Marco Di Battista,
  • Simone Barsotti,
  • Saverio Vitali,
  • Marco Palma,
  • Giammarco Granieri,
  • Teresa Oranges,
  • Giacomo Aringhieri,
  • Valentina Dini,
  • Alessandra Della Rossa and
  • Marta Mosca
  • + 2 authors

Background: To assess skin involvement in a cohort of patients with systemic sclerosis (SSc) by comparing results obtained from modified Rodnan skin score (mRSS), durometry and ultra-high frequency ultrasound (UHFUS). Methods: SSc patients were enrol...

(This article belongs to the Special Issue Clinical Application of Ultra-High Frequency Ultrasound: Emerging Trends)
  • Article
  • Open Access
15 Citations
5,216 Views
19 Pages

This paper proposes ensemble strategies for the deep learning object detection models carried out by combining the variants of a model and different models to enhance the anatomical and pathological object detection performance in brain MRI. In this...

(This article belongs to the Special Issue Application of Deep Learning in the Diagnosis of Brain Diseases)
  • Article
  • Open Access
7 Citations
3,317 Views
15 Pages

Diagnostic Value of Chromosomal Microarray Analysis for Fetal Congenital Heart Defects with Different Cardiac Phenotypes and Extracardiac Abnormalities

  • Simin Zhang,
  • Jingjing Wang,
  • Yan Pei,
  • Jijing Han,
  • Xiaowei Xiong,
  • Yani Yan,
  • Juan Zhang,
  • Yan Liu,
  • Fangfei Su and
  • Qingqing Wu
  • + 1 author

(1) Background: The objective of this study was to investigate the diagnostic value of chromosomal microarray analysis (CMA) for congenital heart defects (CHDs) with different cardiac phenotypes and extracardiac abnormalities (ECAs) and to explore th...

(This article belongs to the Special Issue Fetal Medicine: From Basic Science to Prenatal Diagnosis and Therapy)
  • Systematic Review
  • Open Access
12 Citations
7,966 Views
16 Pages

A Systematic Review of Diagnostic and Prognostic Biomarkers for Head and Neck Cancer of Unknown Primary: An Unmet Clinical Need

  • Daria Maria Filippini,
  • Elisabetta Broseghini,
  • Francesca Carosi,
  • Davide Dal Molin,
  • Mattia Riefolo,
  • Laura Fabbri,
  • Andi Abeshi,
  • Ignacio Javier Fernandez and
  • Manuela Ferracin

Head and neck cancer of unknown primary (HNCUP) is defined as cervical lymph node metastases without a detectable primary tumor. The management of these patients presents a challenge to clinicians since guidelines in the diagnosis and treatment of HN...

(This article belongs to the Special Issue Genomic Approach for Diagnosis, Prognosis and Therapy Prediction in Cancer Research)
  • Article
  • Open Access
6 Citations
3,517 Views
10 Pages

Aortic Dilatation in Pediatric Patients with Bicuspid Aortic Valve: How the Choice of Nomograms May Change Prevalence

  • Gaia Spaziani,
  • Francesca Bonanni,
  • Francesca Girolami,
  • Elena Bennati,
  • Giovanni Battista Calabri,
  • Chiara Di Filippo,
  • Giulio Porcedda,
  • Silvia Passantino,
  • Stefano Nistri and
  • Silvia Favilli
  • + 1 author

Background: Aortic dilation (AoD) is commonly reported in patients with bicuspid aortic valve (BAV) and has been related to flow abnormalities and genetic predisposition. AoD-related complications are reported to be extremely rare in children. Conver...

(This article belongs to the Special Issue Thoracic Aortic Disease: From Bench to Bedside)
  • Article
  • Open Access
20 Citations
3,610 Views
23 Pages

Human Pathogenic Monkeypox Disease Recognition Using Q-Learning Approach

  • Malathi Velu,
  • Rajesh Kumar Dhanaraj,
  • Balamurugan Balusamy,
  • Seifedine Kadry,
  • Yang Yu,
  • Ahmed Nadeem and
  • Hafiz Tayyab Rauf

While the world is working quietly to repair the damage caused by COVID-19’s widespread transmission, the monkeypox virus threatens to become a global pandemic. There are several nations that report new monkeypox cases daily, despite the virus being...

(This article belongs to the Special Issue AI-Driven Intelligent Health Care Diagnostic Solutions: A Machine Learning Approach)
  • Article
  • Open Access
6 Citations
3,721 Views
10 Pages

Activated clotting time (ACT) is used in cardiac surgery for monitoring unfractionated heparin (UFH). In endovascular radiology, ACT use is less established. We aimed to test the validity of ACT in UFH monitoring in endovascular radiology. We recruit...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Review
  • Open Access
24 Citations
5,272 Views
20 Pages

Update on the Applications of Radiomics in Diagnosis, Staging, and Recurrence of Intrahepatic Cholangiocarcinoma

  • Maria Chiara Brunese,
  • Maria Rita Fantozzi,
  • Roberta Fusco,
  • Federica De Muzio,
  • Michela Gabelloni,
  • Ginevra Danti,
  • Alessandra Borgheresi,
  • Pierpaolo Palumbo,
  • Federico Bruno and
  • Vincenza Granata
  • + 4 authors

Background: This paper offers an assessment of radiomics tools in the evaluation of intrahepatic cholangiocarcinoma. Methods: The PubMed database was searched for papers published in the English language no earlier than October 2022. Results: We foun...

(This article belongs to the Special Issue Gastrointestinal and Liver Diseases: New Advances in Diagnosis and Prognosis)
  • Interesting Images
  • Open Access
2 Citations
2,570 Views
7 Pages

Next-generation sequencing technology has improved molecular genetic analysis, and many molecular genetic studies have been utilized for diagnostic classification, risk stratification, and prognosis prediction of acute lymphoblastic leukemia (ALL). I...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
59 Citations
4,788 Views
21 Pages

Metaverse and Medical Diagnosis: A Blockchain-Based Digital Twinning Approach Based on MobileNetV2 Algorithm for Cervical Vertebral Maturation

  • Omid Moztarzadeh,
  • Mohammad (Behdad) Jamshidi,
  • Saleh Sargolzaei,
  • Fatemeh Keikhaee,
  • Alireza Jamshidi,
  • Shabnam Shadroo and
  • Lukas Hauer

Advanced mathematical and deep learning (DL) algorithms have recently played a crucial role in diagnosing medical parameters and diseases. One of these areas that need to be more focused on is dentistry. This is why creating digital twins of dental i...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
34 Citations
6,839 Views
17 Pages

Background: The aim of our study is to provide successful automatic segmentation of various objects on orthopantomographs (OPGs). Methods: 8138 OPGs obtained from the archives of the Department of Dentomaxillofacial Radiology were included. OPGs were...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
7 Citations
2,489 Views
28 Pages

This study proposes a deep-learning-based solution (named CapsNetCovid) for COVID-19 diagnosis using a capsule neural network (CapsNet). CapsNets are robust for image rotations and affine transformations, which is advantageous when processing medical...

(This article belongs to the Special Issue AI and Big Data in Healthcare)
  • Article
  • Open Access
13 Citations
3,513 Views
10 Pages

PAH Pathogenic Variants and Clinical Correlations in a Group of Hyperphenylalaninemia Patients from North-Western Romania

  • Alin Iuhas,
  • Claudia Jurca,
  • Kinga Kozma,
  • Anca-Lelia Riza,
  • Ioana Streață,
  • Codruța Petcheși,
  • Andra Dan,
  • Cristian Sava,
  • Andreea Balmoș and
  • Marius Bembea
  • + 3 authors

Phenylketonuria (PKU) is caused by mutations in the phenylalanine hydroxylase (PAH) gene and is characterized by altered amino acid metabolism. More than 1500 known PAH variants intricately determine a spectrum of metabolic phenotypes. We aim to repo...

(This article belongs to the Special Issue Diagnosis of Neonatal Diseases)
  • Article
  • Open Access
7 Citations
3,147 Views
10 Pages

Comparison of a Presbyopia-Correcting Supplementary Intraocular Lens Combination and a Capsular-Bag Lens: An In Vitro Study

  • Ramin Khoramnia,
  • Isabella Diana Baur,
  • Weijia Yan,
  • Grzegorz Łabuz and
  • Gerd Uwe Auffarth

We evaluated the optical quality of two approaches to trifocality: polypseudophakia versus monopseudophakia. The combination (polypseudophakia) of a monofocal Basis Z B1AWY0 and AddOn Trifocal A4DW0M intraocular lens (IOL) was compared to using one B...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
7 Citations
3,932 Views
22 Pages

Endocardial Fibroelastosis as an Independent Predictor of Atrioventricular Valve Rupture in Maternal Autoimmune Antibody Exposed Fetus: A Systematic Review with Clinicopathologic Analysis

  • Monika Kantilal Kotecha,
  • Khurshid Merchant,
  • Charmaine Jiahui Chan,
  • Jonathan Tze Liang Choo,
  • Krishna Revanna Gopagondanahalli,
  • Dyan Zhewei Zhang,
  • Teng Hong Tan and
  • Sreekanthan Sundararaghavan

Background: Neonatal lupus (NL) is a clinical syndrome that develops in the fetus as a result of maternal autoimmune antibodies. Congenital complete heart block (CHB) is the most common manifestation, while extranodal cardiac manifestations of NL, su...

(This article belongs to the Special Issue Critical Care Imaging)
  • Case Report
  • Open Access
5 Citations
9,102 Views
7 Pages

Nevus Sebaceous of Jadassohn in Adults—Can Reflectance Confocal Microscopy Detect Malignant Transformation?

  • Vlad Mihai Voiculescu,
  • Ana Maria Celarel,
  • Elena Codruta Cozma,
  • Madalina Laura Banciu and
  • Mihai Lupu

Nevus sebaceous of Jadassohn (NSJ) is a rare congenital lesion that affects the adnexal structures of the skin. It is typically located on the scalp and face of females and presents as a well-defined, slightly elevated, yellow lesion. It is also link...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
2,639 Views
13 Pages

This study aimed to develop a computed tomography (CT)-based radiomics model to predict the outcome of COVID-19 pneumonia. In total of 44 patients with confirmed diagnosis of COVID-19 were retrospectively enrolled in this study. The radiomics model a...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
4 Citations
2,287 Views
13 Pages

Multi-b diffusion-weighted hyperpolarized gas MRI measures pulmonary airspace enlargement using apparent diffusion coefficients (ADC) and mean linear intercepts (Lm). Rapid single-breath acquisitions may facilitate clinical translation, and, hence, w...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
17 Citations
6,799 Views
14 Pages

New Technologies in the Assessment of Carotid Stenosis: Beyond the Color-Doppler Ultrasound—High Frame Rate Vector-Flow and 3D Arterial Analysis Ultrasound

  • Emanuele David,
  • Ombretta Martinelli,
  • Patrizia Pacini,
  • Marco Di Serafino,
  • Pintong Huang,
  • Vincenzo Dolcetti,
  • Giovanni Del Gaudio,
  • Richard G. Barr,
  • Maurizio Renda and
  • Vito Cantisani
  • + 5 authors

Atherosclerotic plaque in the carotid artery is the main cause of ischemic stroke, with a high incidence rate among people over 65 years. A timely and precise diagnosis can help to prevent the ischemic event and decide patient management, such as fol...

(This article belongs to the Special Issue Advanced Ultrasound Technologies for Diagnosis)
  • Article
  • Open Access
23 Citations
5,158 Views
12 Pages

Analytical Performance of a Highly Sensitive System to Detect Gene Variants Using Next-Generation Sequencing for Lung Cancer Companion Diagnostics

  • Kikuya Kato,
  • Jiro Okami,
  • Harumi Nakamura,
  • Keiichiro Honma,
  • Yoshiharu Sato,
  • Seiji Nakamura,
  • Yoji Kukita,
  • Shin-ichi Nakatsuka and
  • Masahiko Higashiyama

The recent increase in the number of molecular targeted agents for lung cancer has led to the demand for the simultaneous testing of multiple genes. Although gene panels using next-generation sequencing (NGS) are ideal, conventional panels require a...

(This article belongs to the Special Issue Genomic Approach for Diagnosis, Prognosis and Therapy Prediction in Cancer Research)
  • Article
  • Open Access
16 Citations
5,866 Views
13 Pages

Idiopathic Granulomatous Mastitis or Breast Cancer? A Comparative MRI Study in Patients Presenting with Non-Mass Enhancement

  • Fatma Nur Soylu Boy,
  • Gul Esen Icten,
  • Yasemin Kayadibi,
  • Iksan Tasdelen and
  • Dolunay Alver

Objective: To compare and determine discriminative magnetic resonance imaging (MRI) findings of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) that present as non-mass enhancement. Materials and Methods: This retrospective study inclu...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
15 Citations
4,815 Views
11 Pages

Deep Learning Empowers Endoscopic Detection and Polyps Classification: A Multiple-Hospital Study

  • Ming-Hung Shen,
  • Chi-Cheng Huang,
  • Yu-Tsung Chen,
  • Yi-Jian Tsai,
  • Fou-Ming Liou,
  • Shih-Chang Chang and
  • Nam Nhut Phan

The present study aimed to develop an AI-based system for the detection and classification of polyps using colonoscopy images. A total of about 256,220 colonoscopy images from 5000 colorectal cancer patients were collected and processed. We used the...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
22 Citations
4,430 Views
16 Pages

A Multi-Feature Fusion Framework for Automatic Skin Cancer Diagnostics

  • Samy Bakheet,
  • Shtwai Alsubai,
  • Aml El-Nagar and
  • Abdullah Alqahtani

Malignant melanoma is the most invasive skin cancer and is currently regarded as one of the deadliest disorders; however, it can be cured more successfully if detected and treated early. Recently, CAD (computer-aided diagnosis) systems have emerged a...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
4 Citations
2,923 Views
11 Pages

This study aimed to evaluate cardiac function in a young mouse model of Duchenne muscular dystrophy (mdx) using cardiac magnetic resonance imaging (MRI) with feature tracking and self-gated magnetic resonance cine imaging. Cardiac function was evalua...

(This article belongs to the Special Issue Advances in Cardiovascular Magnetic Resonance)
  • Article
  • Open Access
13 Citations
3,029 Views
11 Pages

The Evaluation of Vascular Endothelial Growth Factor A (VEGFA) and VEGFR2 Receptor as Prognostic Biomarkers in Bladder Cancer

  • Meryem El Azzouzi,
  • Hajar El Ahanidi,
  • Chaimae Hafidi Alaoui,
  • Imane Chaoui,
  • Laila Benbacer,
  • Mohammed Tetou,
  • Ilias Hassan,
  • Mounia Bensaid,
  • Mohamed Oukabli and
  • Mohammed El Mzibri
  • + 3 authors

Vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) are the most important tissue factors involved in tumor growth and angiogenesis. The aim of this study was to evaluate the promoter mutational status of VEGFA and the exp...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
1 Citations
3,865 Views
11 Pages

Validation of a MALDI-TOF MS Method for SARS-CoV-2 Detection on the Bruker Biotyper and Nasopharyngeal Swabs: A Brazil—UK Collaborative Study

  • Otávio A. Lovison,
  • Raminta Grigaitė,
  • Fabiana C. Z. Volpato,
  • Jason K. Iles,
  • Jon Lacey,
  • Fabiano Barreto,
  • Sai R. Pandiri,
  • Lisiane da Luz R. Balzan,
  • Vlademir V. Cantarelli and
  • Andreza F. Martins
  • + 2 authors

We developed a MALDI-TOF mass spectrometry method for the detection of the SARS-CoV-2 virus in saliva-gargle samples using Shimadzu MALDI-TOF mass spectrometers in the UK. This was validated in the USA to CLIA-LDT standards for asymptomatic infection...

(This article belongs to the Special Issue New-Generation Sensors/Prototypes Integrated with Functional Materials for Efficient Diagnostics)
  • Article
  • Open Access
4 Citations
3,580 Views
13 Pages

Simultaneous, Multi-Channel, Near-Infrared Fluorescence Visualization of Mesenteric Lymph Nodes Using Indocyanine Green and Methylene Blue: A Demonstration in a Porcine Model

  • Nariaki Okamoto,
  • Zaid Al-Difaie,
  • Max H. M. C. Scheepers,
  • Danique J. I. Heuvelings,
  • María Rita Rodríguez-Luna,
  • Jacques Marescaux,
  • Michele Diana,
  • Laurents P. S. Stassen,
  • Nicole D. Bouvy and
  • Mahdi Al-Taher

Near-infrared fluorescence (NIRF) image-guided surgery is a useful tool that can help reduce perioperative complications and improve tissue recognition. Indocyanine green (ICG) dye is the most frequently used in clinical studies. ICG NIRF imaging has...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
7 Citations
3,722 Views
11 Pages

Salivary Biomarkers to Differentiate between Streptococcus pneumoniae and Influenza A Virus-Related Pneumonia in Children

  • Kuo-Shu Tang,
  • Chih-Min Tsai,
  • Ming-Chou Cheng,
  • Ying-Hsien Huang,
  • Chih-Hao Chang and
  • Hong-Ren Yu

Community-acquired pneumonia (CAP) is common among children and can be fatal in certain conditions. In children, CAP can be caused by viral or bacterial infections. Identification of pathogens can help select appropriate therapeutic strategies. Saliv...

(This article belongs to the Special Issue Pediatric Diagnostic Microbiology)
  • Article
  • Open Access
2 Citations
3,166 Views
22 Pages

Semi-Supervised KPCA-Based Monitoring Techniques for Detecting COVID-19 Infection through Blood Tests

  • Fouzi Harrou,
  • Abdelkader Dairi,
  • Abdelhakim Dorbane,
  • Farid Kadri and
  • Ying Sun

This study introduces a new method for identifying COVID-19 infections using blood test data as part of an anomaly detection problem by combining the kernel principal component analysis (KPCA) and one-class support vector machine (OCSVM). This approa...

(This article belongs to the Special Issue Diagnostic AI and Viral or Bacterial Infection)
  • Communication
  • Open Access
2 Citations
3,429 Views
15 Pages

A Method for High-Frequency Mechanical Scanning Ultrasonic Flow Imaging with Motion Compensation

  • Jiaming Heng,
  • Chenxi Li,
  • Tianxiang Chu,
  • Yiwen Xu and
  • Xiaohua Jian

Mechanical scanning with a single transducer is an alternative method for high-frequency ultrasound imaging, which is simple in structure, convenient to implement, and low in cost. However, traditional mechanical scanning ultrasonic imaging introduce...

(This article belongs to the Special Issue Ultrasound Imaging in Medicine 2023)
  • Article
  • Open Access
4 Citations
2,672 Views
10 Pages

Interleukin-4 Gene Polymorphisms in Romanian Patients with Inflammatory Bowel Diseases: Association with Disease Risk and Clinical Features

  • Andrei Ovidiu Olteanu,
  • Elena Mirela Ionescu,
  • Cristian George Tieranu,
  • Luis Ovidiu Popa,
  • Silvia Ioana Andrei,
  • Carmen Monica Preda,
  • Monica Irina Dutescu,
  • Mihai Bojinca,
  • Ioana Tieranu and
  • Olivia Mihaela Popa

1. Introduction. Multiple cytokines have been studied for their role in the propagation of the inflammatory process related to inflammatory bowel diseases (IBD), but the role of interleukin-4 remains controversial. The aim of this study was to evalua...

(This article belongs to the Special Issue Gastrointestinal and Liver Diseases: New Advances in Diagnosis and Prognosis)
  • Article
  • Open Access
21 Citations
4,178 Views
13 Pages

MoS2-ZnO Nanocomposite Mediated Immunosensor for Non-Invasive Electrochemical Detection of IL8 Oral Tumor Biomarker

  • Cittrarasu Vetrivel,
  • Ganesan Sivarasan,
  • Kaliannan Durairaj,
  • Chinnasamy Ragavendran,
  • Chinnaperumal Kamaraj,
  • Sankar Karthika and
  • Huang-Mu Lo

In order to support biomolecule attachment, an effective electrochemical transducer matrix for biosensing devices needs to have many specialized properties, including quick electron transfer, stability, high surface area, biocompatibility, and the pr...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
6 Citations
3,180 Views
12 Pages

Clostridioides difficile infection (CDI) is a major healthcare-associated infection that leads to a significant health economic burden in Japan. Using a decision tree model, we evaluated the budget impact of adopting a one-step nucleic acid amplifica...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
24 Citations
4,976 Views
15 Pages

Anti-Aliasing Attention U-net Model for Skin Lesion Segmentation

  • Phuong Thi Le,
  • Bach-Tung Pham,
  • Ching-Chun Chang,
  • Yi-Chiung Hsu,
  • Tzu-Chiang Tai,
  • Yung-Hui Li and
  • Jia-Ching Wang

The need for a lightweight and reliable segmentation algorithm is critical in various biomedical image-prediction applications. However, the limited quantity of data presents a significant challenge for image segmentation. Additionally, low image qua...

(This article belongs to the Special Issue Artificial Intelligence in the Detection and Classification of Skin Diseases)
  • Article
  • Open Access
10 Citations
3,800 Views
17 Pages

Motion sickness is a common physiological discomfort phenomenon during car rides. In this paper, the functional near-infrared spectroscopy (fNIRS) technique was used in real-world vehicle testing. The fNIRS technique was utilized to model the relatio...

(This article belongs to the Special Issue Wearable Sensors and Artificial Intelligence for Ergonomics)
  • Review
  • Open Access
7 Citations
6,409 Views
25 Pages

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

  • Chung-Ting Wang,
  • Yin-Hsi Chang,
  • Gavin S. W. Tan,
  • Shu Yen Lee,
  • R. V. Paul Chan,
  • Wei-Chi Wu and
  • Andrew S. H. Tsai

Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in viv...

(This article belongs to the Special Issue Advances in Optical Coherence Tomography and Optical Coherence Tomography Angiography in Diseases of the Retina and Choroid)
  • Case Report
  • Open Access
3 Citations
2,640 Views
10 Pages

Myocardial Work Evaluation—A Useful Non-Invasive Method to Predict Coronary Artery Sub-Occlusion in a Patient with Unstable Angina and Multiple Myocardial Revascularization Interventions

  • Alexandru Gheorghiu,
  • Sergiu-Florin Arnautu,
  • Milena Slovenski,
  • Claudiu-Daniel Malița,
  • Mirela-Cleopatra Tomescu and
  • Diana-Aurora Arnautu

Background: While lifestyle changes, management of coronary artery disease (CAD) risk factors, myocardial revascularization procedures, and medication can improve a patient’s prognosis, de novo native coronary lesions and in-stent restenosis (I...

(This article belongs to the Section Medical Imaging and Theranostics)

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Diagnostics - ISSN 2075-4418