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Diagnostics, Volume 13, Issue 1

January-1 2023 - 168 articles

Cover Story: Chest X-ray (CXR) is among the most frequently used medical imaging modalities by Radiologists and Physicians. It has a preeminent value in the detection of multiple life-threatening diseases. Most thoracic diseases have similar patterns, which makes diagnosis prone to human error. Deep learning (DL) provides techniques to make this task more efficient. This work reviews recent advances in DL for CXR disease detection. We present the developed algorithms, the preprocessing techniques and the available datasets. We discuss the challenges present in the published literature and highlight the importance of interpretability and explainability to better understand the models’ detections. Finally, we outline a direction for researchers to help develop more effective models for the early detection of chest diseases. View this paper 
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Articles (168)

  • Review
  • Open Access
24 Citations
8,388 Views
16 Pages

Prostate-specific membrane antigen (PSMA) is a 100 kD, 750 amino acid (AA) long type II transmembrane glycoprotein that has a short N-terminal intracellular domain with 19 AA, 24 AA transmembrane proteins and a large C-terminal extracellular domain w...

  • Article
  • Open Access
1 Citations
2,966 Views
11 Pages

Performance of Deauville Criteria in [18F]FDG-PET/CT Diagnostics of Giant Cell Arteritis

  • Jeffrey Siefert,
  • Jonas Kaufmann,
  • Felix Thiele,
  • Thula Walter-Rittel,
  • Julian Rogasch,
  • Robert Biesen,
  • Gerd R. Burmester,
  • Holger Amthauer,
  • Udo Schneider and
  • Christian Furth

In this retrospective study, PET/CT data from 59 patients with suspected giant cell arteritis (GCA) were reviewed using the Deauville criteria to determine an optimal cut-off between PET positivity and negativity. Seventeen standardised vascular regi...

  • Article
  • Open Access
5 Citations
4,204 Views
13 Pages

Deciphering the Autoantibody Response to the OJ Antigenic Complex

  • Marvin J. Fritzler,
  • Chelsea Bentow,
  • Minoru Satoh,
  • Neil McHugh,
  • Anna Ghirardello and
  • Michael Mahler

(1) Background: Myositis specific antibodies (MSA) are important diagnostic biomarkers. Among the rarest and most challenging MSA are anti-OJ antibodies which are associated with anti-synthetase syndrome (ASS). In contrast to the other tRNA synthetas...

  • Article
  • Open Access
20 Citations
4,718 Views
15 Pages

Loop-mediated isothermal amplification is a promising candidate for the rapid detection of Mycobacterium tuberculosis. However, the high potential for carry-over contamination is the main obstacle to its routine use. Here, a closed tube LAMP was inte...

  • Article
  • Open Access
4 Citations
3,232 Views
13 Pages

Prognostic Value of Bladder Involvement in the Outcome of Upper Tract Urothelial Carcinoma

  • Sara Meireles,
  • Nuno Dias,
  • Diana Martins,
  • Carolina Dias,
  • Marina Gonçalves,
  • João Silva,
  • Carlos Martins Silva,
  • Paulo Dinis Oliveira,
  • Paula Soares and
  • José Manuel Lopes

Accurately predicting the clinical prognosis of upper tract urothelial carcinoma (UTUC) seems crucial. We evaluated the effect of the involvement of urothelial bladder carcinoma (UBC) as a potential prognostic factor for overall survival (OS) and pro...

  • Interesting Images
  • Open Access
2 Citations
8,567 Views
7 Pages

Popcorn Appearance of Severely Calcified Uterine Leiomyoma: Image-Pathological Correlation

  • Charuwan Tantipalakorn,
  • Surapan Khunamornpong,
  • Sirinart Sirilert and
  • Theera Tongsong

Calcified subserous leiomyoma is a rare benign tumor commonly seen in the postmenopausal age group. Cases with severely calcified degeneration all over the mass are extremely rare. It causes diagnostic confusion with the solid calcified adnexal mass...

  • Article
  • Open Access
1 Citations
3,011 Views
12 Pages

Follow-Up Infarct Volume Prediction by CTP-Based Hypoperfusion Index, and the Discrepancy between Small Follow-Up Infarct Volume and Poor Functional Outcome—A Multicenter Study

  • Pengyu Zhou,
  • Ran Li,
  • Siyun Liu,
  • Jincheng Wang,
  • Lixiang Huang,
  • Bin Song,
  • Xiaoqiang Tang,
  • Boyu Chen,
  • Haiting Yang and
  • Chengcheng Zhu
  • + 2 authors

(1) Background: Follow-up infarct volume (FIV) may have implications for prognostication in acute ischemic stroke patients. Factors predicting the discrepancy between FIV and 90-day outcomes are poorly understood. We aimed to develop a comprehensive...

  • Article
  • Open Access
2 Citations
2,234 Views
15 Pages

Computational Design and Experimental Evaluation of MERS-CoV siRNAs in Selected Cell Lines

  • Sayed S. Sohrab,
  • Sherif A. El-Kafrawy,
  • Zeenat Mirza,
  • Ahmed M. Hassan,
  • Fatima Alsaqaf and
  • Esam I. Azhar

Middle East respiratory syndrome coronavirus (MERS-CoV) is caused by a well-known coronavirus first identified in a hospitalized patient in the Kingdom of Saudi Arabia. MERS-CoV is a serious pathogen affecting both human and camel health globally, wi...

  • Review
  • Open Access
11 Citations
3,576 Views
15 Pages

Haemostasis and Inflammatory Parameters as Potential Diagnostic Biomarkers for VTE in Trauma-Immobilized Patients

  • Noor Nabila Ramli,
  • Salfarina Iberahim,
  • Noor Haslina Mohd Noor,
  • Zefarina Zulkafli,
  • Tengku Muzaffar Tengku Md Shihabuddin,
  • Mohd Hadizie Din,
  • Muhamad Aizat Mohamed Saat and
  • Ahmad Hadif Zaidin Samsudin

Venous thromboembolism (VTE), which encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE), is a major public health concern due to its high incidences of morbidity and mortality. Patients who have experienced trauma with prolonged immo...

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Diagnostics - ISSN 2075-4418