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Diagnostics, Volume 13, Issue 2

2023 January-2 - 163 articles

Cover Story: Several studies indicate that THSD7A might play a role at least in the prognosis of different tumor types. FAK is believed to play an important role in prostate cancer and is discussed as a potential therapeutic target, especially in advanced stages. Moreover, there is evidence that FAK-dependent signaling pathways might be affected by THSD7A. For this reason, we examined whether THSD7A expression status has an impact on the expression level of FAK in its unphosphorylated form. To our knowledge, we are the first to show that THSD7A-positivity is significantly associated with high FAK expression in prostate cancer. Given the potential involvement of THSD7A in FAK-dependent signaling pathways, THSD7A has to be discussed as a therapeutic target in prostate cancer. View this paper
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Articles (163)

  • Review
  • Open Access
14 Citations
14,208 Views
16 Pages

Uterine Perforation as a Complication of the Intrauterine Procedures Causing Omentum Incarceration: A Review

  • George Lucian Zorilă,
  • Răzvan Grigoraș Căpitănescu,
  • Roxana Cristina Drăgușin,
  • Anca-Maria Istrate-Ofițeru,
  • Elena Bernad,
  • Mădălina Dobie,
  • Sandor Bernad,
  • Marius Craina,
  • Iuliana Ceaușu and
  • Dominic Gabriel Iliescu
  • + 5 authors

Objective: Omentum involvement resulting from uterine perforation is a rare complication following intrauterine procedures that might require immediate intervention due to severe ischemic consequences. This review examines the prevalence of this comp...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Communication
  • Open Access
5 Citations
3,340 Views
8 Pages

SARS-CoV-2 Detection via RT-PCR in Matched Saliva and Nasopharyngeal Samples Reveals High Concordance in Different Commercial Assays

  • Karoline Almeida Felix de Sousa,
  • Carolina Kymie Vasques Nonaka,
  • Renata Naves de Ávila Mendonça,
  • Verena Neiva Mascarenhas,
  • Thamires Gomes Lopes Weber,
  • Carlos Gustavo Regis Silva,
  • Ana Verena Almeida Mendes,
  • Ricardo Khouri,
  • Bruno Solano Freitas Souza and
  • Clarissa Araújo Gurgel Rocha

Background: Self-collected saliva samples can increase the diagnostic efficiency and benefit healthcare workers, patient care, and infection control. This study evaluated the performance of self-collected saliva samples compared to nasopharyngeal swa...

(This article belongs to the Special Issue SARS-CoV-2 Identification by Diagnostic/Medical Laboratory: Methods, Statistics, Interesting Cases)
  • Article
  • Open Access
7 Citations
4,231 Views
12 Pages

3D Reconstruction of Wrist Bones from C-Arm Fluoroscopy Using Planar Markers

  • Pragyan Shrestha,
  • Chun Xie,
  • Hidehiko Shishido,
  • Yuichi Yoshii and
  • Itaru Kitahara

In orthopedic surgeries, such as osteotomy and osteosynthesis, an intraoperative 3D reconstruction of the bone would enable surgeons to quickly assess the fracture reduction procedure with preoperative planning. Scanners equipped with such functional...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
6,656 Views
12 Pages

Outcome Measures of In-Office Endovenous Radiofrequency Treatment of Varicose Vein Feasibility

  • Alfonso Pannone,
  • Alessia Di Girolamo,
  • Matteo Orrico and
  • Nicola Mangialardi

RFA is a relatively new treatment, approved by the FDA in 1999 and is a minimally invasive intervention that has become one of the most common alternatives due to its many advantages, including decreased pain, less morbidity, shorter hospital stay an...

(This article belongs to the Collection Vascular Diseases Diagnostics)
  • Article
  • Open Access
11 Citations
4,485 Views
15 Pages

Utilisation of 3D Printing in the Manufacturing of an Anthropomorphic Paediatric Head Phantom for the Optimisation of Scanning Parameters in CT

  • Merim Jusufbegović,
  • Adi Pandžić,
  • Mustafa Busuladžić,
  • Lejla M. Čiva,
  • Azra Gazibegović-Busuladžić,
  • Adnan Šehić,
  • Sandra Vegar-Zubović,
  • Rahima Jašić and
  • Adnan Beganović

Computed tomography (CT) is a diagnostic imaging process that uses ionising radiation to obtain information about the interior anatomic structure of the human body. Considering that the medical use of ionising radiation implies exposing patients to r...

(This article belongs to the Special Issue Advancements in Neuroimaging)
  • Article
  • Open Access
5 Citations
2,969 Views
12 Pages

Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients

  • Mohamed Khalil,
  • Nahla Elsharkawy,
  • Mona Mohsen Elmawardy and
  • Mahmoud Aly Ayoub

Background: Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 e...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
38 Citations
8,010 Views
19 Pages

Deep Learning in Optical Coherence Tomography Angiography: Current Progress, Challenges, and Future Directions

  • Dawei Yang,
  • An Ran Ran,
  • Truong X. Nguyen,
  • Timothy P. H. Lin,
  • Hao Chen,
  • Timothy Y. Y. Lai,
  • Clement C. Tham and
  • Carol Y. Cheung

Optical coherence tomography angiography (OCT-A) provides depth-resolved visualization of the retinal microvasculature without intravenous dye injection. It facilitates investigations of various retinal vascular diseases and glaucoma by assessment of...

(This article belongs to the Special Issue Deep Learning Applications in Ophthalmology)
  • Article
  • Open Access
27 Citations
6,010 Views
11 Pages

The Clinical Impact of Metagenomic Next-Generation Sequencing (mNGS) Test in Hospitalized Patients with Suspected Sepsis: A Multicenter Prospective Study

  • Yi-Hui Zuo,
  • Yi-Xing Wu,
  • Wei-Ping Hu,
  • Yan Chen,
  • Yu-Ping Li,
  • Zhen-Ju Song,
  • Zhe Luo,
  • Min-Jie Ju,
  • Min-Hua Shi and
  • Jing Zhang
  • + 5 authors

Background: Metagenomic Next Generation Sequencing (mNGS) has the potential to detect pathogens rapidly. We aimed to assess the diagnostic performance of mNGS in hospitalized patients with suspected sepsis and evaluate its role in guiding antimicrobi...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
7 Citations
3,469 Views
14 Pages

Sex-Specific Cut-Offs of Single Point Insulin Sensitivity Estimator (SPISE) in Predicting Metabolic Syndrome in the Arab Adolescents

  • Kaiser Wani,
  • Malak N. K. Khattak,
  • Gamal M. Saadawy,
  • Omar S. Al-Attas,
  • Majed S. Alokail and
  • Nasser M. Al-Daghri

The Single Point Insulin Sensitivity Estimator (SPISE) is a novel surrogate marker for insulin sensitivity and was found comparable to the gold standard clamp test as well as for predicting the Metabolic Syndrome (MetS) in several populations. The pr...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
19 Citations
15,532 Views
12 Pages

Could Spinal Epidural Lipomatosis Be the Hallmark of Metabolic Syndrome on the Spine? A Literature Review with Emphasis on Etiology

  • Valerio D’Agostino,
  • Miriana Rosaria Petrera,
  • Giuseppe Tedesco,
  • Valerio Pipola,
  • Federico Ponti and
  • Paolo Spinnato

Spinal epidural lipomatosis is defined by an excessive amount of epidural fat in the spinal canal, usually in the lumbosacral tract: a well-known cause of lumbar pain and spinal stenosis with a possible wide range of neurological symptoms. Recent res...

(This article belongs to the Special Issue Improving Imaging Diagnosis: From Conventional Radiology to Advanced Imaging Techniques)
  • Review
  • Open Access
31 Citations
18,501 Views
17 Pages

Barrett’s Esophagus: An Updated Review

  • Peter M. Stawinski,
  • Karolina N. Dziadkowiec,
  • Lily A. Kuo,
  • Juan Echavarria and
  • Shreyas Saligram

Barrett’s esophagus (BE) is a change in the distal esophageal mucosal lining, whereby metaplastic columnar epithelium replaces squamous epithelium of the esophagus. This change represents a pre-malignant mucosal transformation which has a known assoc...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
27 Citations
8,822 Views
14 Pages

The Role of CRP POC Testing in the Fight against Antibiotic Overuse in European Primary Care: Recommendations from a European Expert Panel

  • Ivan Gentile,
  • Nicola Schiano Moriello,
  • Rogier Hopstaken,
  • Carl Llor,
  • Hasse Melbye and
  • Oliver Senn

Tackling antibiotic resistance represents one of the major challenges in modern medicine, and limiting antibiotics’ overuse represents the first step in this fight. Most antibiotics are prescribed in primary care settings, and lower respiratory...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
3 Citations
4,574 Views
10 Pages

Clinical Significance of Maximum Intensity Projection Method for Diagnostic Imaging of Thoracic Outlet Syndrome

  • Takeshi Ogawa,
  • Shinzo Onishi,
  • Naotaka Mamizuka,
  • Yuichi Yoshii,
  • Kazuhiro Ikeda,
  • Takeo Mammoto and
  • Masashi Yamazaki

The aim of this study was to use the magnetic resonance imaging maximum-intensity projection (MRI-MIP) method for diagnostic imaging of thoracic outlet syndrome (TOS) and to investigate the stricture ratios of the subclavian artery (SCA), subclavian...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
6 Citations
5,303 Views
15 Pages

Standardized Uptake Values on SPECT/CT: A Promising Alternative Tool for Treatment Evaluation and Prognosis of Metastatic Neuroendocrine Tumours

  • Mirela Gherghe,
  • Alexandra Maria Lazar,
  • Laurentiu Simion,
  • Ionela-Nicoleta Irimescu,
  • Maria-Carla Sterea,
  • Mario-Demian Mutuleanu and
  • Rodica Maricela Anghel

(1) Background: The aim of our study was to assess the feasibility of 99mTcEDDA/HYNIC-TOC SPECT/CT quantitative analysis in evaluating treatment response and disease progression in patients with NETs. (2) Methods: This prospective monocentric study e...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
11 Citations
3,920 Views
10 Pages

Kinetics of the Cell Cycle Arrest Biomarkers (TIMP2 and IGFBP7) for the Diagnosis of Acute Kidney Injury in Critically Ill COVID-19 Patients

  • Massimiliano Greco,
  • Silvia De Rosa,
  • Fabian Boehm,
  • Sofia Spano,
  • Romina Aceto,
  • Antonio Voza,
  • Francesco Reggiani,
  • Marta Calatroni,
  • Gianluca Castellani and
  • Maurizio Cecconi
  • + 2 authors

Background: Acute kidney injury (AKI) is highly prevalent in critical COVID-19 patients. The diagnosis and staging of AKI are based on serum creatinine (sCr) and urinary output criteria, with limitations in the functional markers. New cell-cycle arre...

(This article belongs to the Special Issue Predictive and Prognostic Markers in Critically Ill Patients)
  • Review
  • Open Access
7 Citations
9,073 Views
15 Pages

The Neoplastic Side of the Abdominal Wall: A Comprehensive Pictorial Essay of Benign and Malignant Neoplasms

  • Giorgia Porrello,
  • Roberto Cannella,
  • Eduardo Alvarez-Hornia Pérez,
  • Giuseppe Brancatelli and
  • Federica Vernuccio

Abdominal wall neoplasms are usually benign and, in the majority of these cases, no further work-up or treatment is indicated. The percentage of malignant abdominal neoplasms, however, is not negligible. Radiologists play a pivotal role in identifyin...

(This article belongs to the Special Issue Improving Imaging Diagnosis: From Conventional Radiology to Advanced Imaging Techniques)
  • Article
  • Open Access
17 Citations
7,544 Views
11 Pages

Polycystic Ovary Syndrome, Subclinical Hypothyroidism, the Cut-Off Value of Thyroid Stimulating Hormone; Is There a Link? Findings of a Population-Based Study

  • Ehsan Rojhani,
  • Maryam Rahmati,
  • Faegheh Firouzi,
  • Marzieh Saei Ghare Naz,
  • Fereidoun Azizi and
  • Fahimeh Ramezani Tehrani

Despite solid evidence regarding the association of over-hypothyroidism with polycystic ovary syndrome (PCOS), the relationship between PCOS and subclinical hypothyroidism (SCH) is still a topic of debate. In the present population-based study, we ai...

(This article belongs to the Special Issue Diagnosis of Polycystic Ovary Syndrome (PCOS): State-of-the-Art and Open Questions)
  • Article
  • Open Access
4 Citations
2,347 Views
8 Pages

Aims: To compare retinal nerve fiber layer (RNFL) thickness and choroidal thickness in patients with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) for 1–5 years or 6–10 years compared to healthy volunteers. Methods and Materia...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
13 Citations
3,152 Views
12 Pages

Objectives: To explore the relationship between peripheral blood inflammation parameters and overall survival (OS) and progression-free survival (PFS) of early-stage non-small cell lung cancer patients who underwent stereotactic body radiotherapy (SB...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
40 Citations
3,966 Views
21 Pages

Over the last few years, brain tumor-related clinical cases have increased substantially, particularly in adults, due to environmental and genetic factors. If they are unidentified in the early stages, there is a risk of severe medical complications,...

(This article belongs to the Special Issue Brain Tumor Imaging)
  • Article
  • Open Access
1 Citations
3,001 Views
10 Pages

Application of Teeth in Toxicological Analysis of Decomposed Cadavers Using a Carbamazepine-Administered Rat Model

  • Hiroaki Ichioka,
  • Urara Saito,
  • Kaori Shintani-Ishida,
  • Takahira Shirahase,
  • Nozomi Idota,
  • Narisato Kanamura and
  • Hiroshi Ikegaya

In a regular autopsy, blood and organs are used to quantify drug and toxicant concentrations; however, specimens such as blood cannot be collected from highly decomposed corpses, making the quantification of drug and toxicants impossible. This study...

(This article belongs to the Special Issue Diagnostic Methods in Forensic Pathology)
  • Review
  • Open Access
44 Citations
6,977 Views
17 Pages

Multidisciplinary Forensic Approach in “Complex” Bodies: Systematic Review and Procedural Proposal

  • Gennaro Baldino,
  • Cristina Mondello,
  • Daniela Sapienza,
  • Chiara Stassi,
  • Alessio Asmundo,
  • Patrizia Gualniera,
  • Stefano Vanin and
  • Elvira Ventura Spagnolo

The recovery of severely altered cadavers (i.e., extensively decomposed, mummified, charred or dismembered) can be a challenge for forensic pathologists due to the difficulties in identification, PMI estimation and manner and cause of death determina...

(This article belongs to the Special Issue Diagnostic Methods in Forensic Pathology)
  • Article
  • Open Access
13 Citations
4,821 Views
10 Pages

Near-infrared technology is an emerging non-invasive technique utilized for various medical applications. Recently, there have been many attempts to utilize NIR technology for the continues monitoring of blood glucose levels through the skin. Differe...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
23 Citations
7,676 Views
19 Pages

Advanced Time-Frequency Methods for ECG Waves Recognition

  • Ala’a Zyout,
  • Hiam Alquran,
  • Wan Azani Mustafa and
  • Ali Mohammad Alqudah

ECG wave recognition is one of the new topics where only one of the ECG beat waves (P-QRS-T) was used to detect heart diseases. Normal, tachycardia, and bradycardia heart rhythm are hard to detect using either time-domain or frequency-domain features...

(This article belongs to the Special Issue Medical Data Processing and Analysis)
  • Article
  • Open Access
7 Citations
5,984 Views
15 Pages

Fetal Ultrasound and Magnetic Resonance Imaging Abnormalities in Congenital Cytomegalovirus Infection Associated with and without Fetal Growth Restriction

  • Kenji Tanimura,
  • Akiko Uchida,
  • Mizuki Uenaka,
  • Hitomi Imafuku,
  • Shinya Tairaku,
  • Hiromi Hashimura,
  • Yoshiko Ueno,
  • Takumi Kido and
  • Kazumichi Fujioka

Congenital cytomegalovirus infection (cCMV) can cause fetal growth restriction (FGR) and severe sequelae in affected infants. Clinicians generally suspect cCMV based on multiple ultrasound (US) findings associated with cCMV. However, no studies have...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
2,484 Views
10 Pages

Impact of ACE and Endoplasmic Reticulum Aminopeptidases Polymorphisms on COVID-19 Outcome

  • Amany A. Ghazy,
  • Abdulrahman H. Almaeen,
  • Ibrahim A. Taher,
  • Abdullah N. Alrasheedi and
  • Amel Elsheredy

Background: COVID-19 outcomes display multiple unexpected varieties, ranging from unnoticed symptomless infection to death, without any previous alarm or known aggravating factors. Aim: To appraise the impact of ACErs4291(A/T) and ERAP1rs26618(T/C) h...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
22 Citations
4,535 Views
13 Pages

Radiomics in Cardiac Computed Tomography

  • Isabelle Ayx,
  • Matthias F. Froelich,
  • Stefan Baumann,
  • Theano Papavassiliu and
  • Stefan O. Schoenberg

In recent years, there has been an increasing recognition of coronary computed tomographic angiography (CCTA) and gated non-contrast cardiac CT in the workup of coronary artery disease in patients with low and intermediate pretest probability, throug...

(This article belongs to the Special Issue Coronary Artery Disease Assessment and Pre-procedural Planning Using Cardiac Computed Tomography)
  • Review
  • Open Access
31 Citations
9,162 Views
15 Pages

Role of Iron Deficiency in Heart Failure—Clinical and Treatment Approach: An Overview

  • Cristina Elena Singer,
  • Corina Maria Vasile,
  • Mihaela Popescu,
  • Alin Iulian Silviu Popescu,
  • Iulia Cristina Marginean,
  • George Alexandru Iacob,
  • Mihai Daniel Popescu and
  • Cristina Maria Marginean

Background: The association of chronic heart failure (CHF) and iron deficiency (ID) with or without anemia is frequently encountered in current medical practice and has a negative prognostic impact, worsening patients’ exercise capacity and inc...

(This article belongs to the Special Issue Advances in the Pathology of Lung, Brain, and Heart Diseases)
  • Review
  • Open Access
44 Citations
15,064 Views
19 Pages

IgA Nephropathy: Current Understanding and Perspectives on Pathogenesis and Targeted Treatment

  • Yating Du,
  • Tingzhu Cheng,
  • Chenxuan Liu,
  • Tingting Zhu,
  • Chuan Guo,
  • Shen Li,
  • Xiangrong Rao and
  • Jinpu Li

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with varied clinical and histopathological features between individuals, particularly across races. As an autoimmune disease, IgAN arises from consequences o...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
6 Citations
5,021 Views
20 Pages

Immunotherapy Assessment: A New Paradigm for Radiologists

  • Vincenza Granata,
  • Roberta Fusco,
  • Sergio Venanzio Setola,
  • Igino Simonetti,
  • Carmine Picone,
  • Ester Simeone,
  • Lucia Festino,
  • Vito Vanella,
  • Maria Grazia Vitale and
  • Antonella Petrillo
  • + 4 authors

Immunotherapy denotes an exemplar change in an oncological setting. Despite the effective application of these treatments across a broad range of tumors, only a minority of patients have beneficial effects. The efficacy of immunotherapy is affected b...

(This article belongs to the Special Issue Imaging Diagnosis in Abdomen)
  • Review
  • Open Access
25 Citations
5,536 Views
20 Pages

Machine Learning in Colorectal Cancer Risk Prediction from Routinely Collected Data: A Review

  • Bruce Burnett,
  • Shang-Ming Zhou,
  • Sinead Brophy,
  • Phil Davies,
  • Paul Ellis,
  • Jonathan Kennedy,
  • Amrita Bandyopadhyay,
  • Michael Parker and
  • Ronan A. Lyons

The inclusion of machine-learning-derived models in systematic reviews of risk prediction models for colorectal cancer is rare. Whilst such reviews have highlighted methodological issues and limited performance of the models included, it is unclear w...

(This article belongs to the Collection Reviews on Artificial Intelligence and Natural Language Processing in Medical Diagnostics)
  • Article
  • Open Access
7 Citations
2,532 Views
15 Pages

The Effect of Magnetic Resonance Imaging Based Radiomics Models in Discriminating stage I–II and III–IVa Nasopharyngeal Carcinoma

  • Quanjiang Li,
  • Qiang Yu,
  • Beibei Gong,
  • Youquan Ning,
  • Xinwei Chen,
  • Jinming Gu,
  • Fajin Lv,
  • Juan Peng and
  • Tianyou Luo

Background: Nasopharyngeal carcinoma (NPC) is a common tumor in China. Accurate stages of NPC are crucial for treatment. We therefore aim to develop radiomics models for discriminating early-stage (I–II) and advanced-stage (III–IVa) NPC b...

(This article belongs to the Special Issue AI/ML-Based Medical Image Processing and Analysis)
  • Article
  • Open Access
22 Citations
3,530 Views
13 Pages

Lightweight Separable Convolution Network for Breast Cancer Histopathological Identification

  • Grace Ugochi Nneji,
  • Happy Nkanta Monday,
  • Goodness Temofe Mgbejime,
  • Venkat Subramanyam R. Pathapati,
  • Saifun Nahar and
  • Chiagoziem Chima Ukwuoma

Breast cancer is one of the leading causes of death among women worldwide. Histopathological images have proven to be a reliable way to find out if someone has breast cancer over time, however, it could be time consuming and require much resources wh...

(This article belongs to the Special Issue Breast Cancer Imaging: Successes and Challenges)
  • Article
  • Open Access
14 Citations
6,476 Views
10 Pages

Styloid Jugular Nutcracker: The Possible Role of the Styloid Process Spatial Orientation—A Preliminary Morphometric Computed Study

  • Giorgio Mantovani,
  • Pietro Zangrossi,
  • Maria Elena Flacco,
  • Giovanni Di Domenico,
  • Enrico Nastro Siniscalchi,
  • Francesco Saverio De Ponte,
  • Rosario Maugeri,
  • Pasquale De Bonis,
  • Michele Alessandro Cavallo and
  • Alba Scerrati
  • + 1 author

Styloid Jugular Nutcracker (SJN, also known as Eagle Jugular Syndrome EJS) derives from a jugular stenosis caused by an abnormal styloid process, compressing the vessel in its superior portion (J3) against the C1 anterior arch. It could be considered...

(This article belongs to the Collection Vascular Diseases Diagnostics)
  • Article
  • Open Access
21 Citations
10,728 Views
12 Pages

Analytical Performances of the Novel i-STAT Alinity Point-of-Care Analyzer

  • Romaric Larcher,
  • Maxence Lottelier,
  • Stephanie Badiou,
  • Anne-Marie Dupuy,
  • Anne-Sophie Bargnoux and
  • Jean-Paul Cristol

Many Point-of-Care devices have been released over the past decade. However, data regarding their analytical performances in real-world situations remains scarce. Herein, we aimed to assess the analytical performances of the i-STAT Alinity system. We...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Interesting Images
  • Open Access
3 Citations
3,188 Views
4 Pages

An Exceptional Cause of Increased 18F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule

  • Ringo Manta,
  • Raoul Muteganya,
  • Abraham J. Beun,
  • Jennifer Fallas and
  • Kris G. Poppe

A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FN...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
10 Citations
3,024 Views
12 Pages

Antiretroviral Levels in the Cerebrospinal Fluid: The Effect of Inflammation and Genetic Variants

  • Jessica Cusato,
  • Valeria Avataneo,
  • Miriam Antonucci,
  • Mattia Trunfio,
  • Letizia Marinaro,
  • Alice Palermiti,
  • Alessandra Manca,
  • Giovanni Di Perri,
  • Jacopo Mula and
  • Andrea Calcagno
  • + 2 authors

Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood–brain barrier (BBBi), along with host genetic variants in transporter genes, may affect an...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
11 Citations
6,865 Views
10 Pages

Glucose-galactose malabsorption is a rare inherited autosomal recessive genetic defect. A mutation in the glucose sodium-dependent transporter-1 gene will alter the transportation and absorption of glucose and galactose in the intestine. The defect i...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Systematic Review
  • Open Access
65 Citations
16,644 Views
38 Pages

Functional gastrointestinal disorders (FGID) and gastroesophageal reflux (GERD) disease affect a large global population and incur substantial health care costs. Impairment in gut-brain communication is one of the main causes of these disorders. The...

(This article belongs to the Special Issue Functional Gastrointestinal Disorders (FGIDs): Diagnosis and Pathophysiology)
  • Article
  • Open Access
85 Citations
9,724 Views
14 Pages

Computer-Aided Detection and Classification of Monkeypox and Chickenpox Lesion in Human Subjects Using Deep Learning Framework

  • Dilber Uzun Ozsahin,
  • Mubarak Taiwo Mustapha,
  • Berna Uzun,
  • Basil Duwa and
  • Ilker Ozsahin

Monkeypox is a zoonotic viral disease caused by the monkeypox virus. After its recent outbreak, it has become clear that a rapid, accurate, and reliable diagnosis may help reduce the risk of a future outbreak. The presence of skin lesions is one of t...

(This article belongs to the Special Issue Artificial Intelligence and Machine Learning for Infectious Diseases)
  • Review
  • Open Access
13 Citations
4,085 Views
31 Pages

Degenerative nerve diseases such as Alzheimer’s and Parkinson’s diseases have always been a global issue of concern. Approximately 1/6th of the world’s population suffers from these disorders, yet there are no definitive solutions t...

(This article belongs to the Special Issue Deep Disease Detection and Diagnosis Models)
  • Comment
  • Open Access
1 Citations
1,786 Views
3 Pages

Systemic arterial hypertension in adults is generally defined as a systolic blood pressure (SBP) of >140 mmHg and/or a diastolic blood pressure (DBP) of >90 mmHg [...]

(This article belongs to the Special Issue New Progress in Diagnostics of Clinical Hypertension)
  • Review
  • Open Access
13 Citations
3,729 Views
11 Pages

Introduction: The COVID-19 pandemic had an unprecedented global effect on teaching and education. This review discusses research, education and diagnostics from the perspectives of four academic clinicians and researchers across different facilities...

(This article belongs to the Special Issue SARS-CoV-2 Identification by Diagnostic/Medical Laboratory: Methods, Statistics, Interesting Cases)
  • Article
  • Open Access
13 Citations
4,730 Views
13 Pages

Prediction of HELLP Syndrome Severity Using Machine Learning Algorithms—Results from a Retrospective Study

  • Marian Melinte-Popescu,
  • Ingrid-Andrada Vasilache,
  • Demetra Socolov and
  • Alina-Sînziana Melinte-Popescu

(1) Background: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a rare and life-threatening complication of preeclampsia. The aim of this study was to evaluate and compare the predictive performances of four machine learning-...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
57 Citations
10,052 Views
23 Pages

Natural Language Processing Applications for Computer-Aided Diagnosis in Oncology

  • Chengtai Li,
  • Yiming Zhang,
  • Ying Weng,
  • Boding Wang and
  • Zhenzhu Li

In the era of big data, text-based medical data, such as electronic health records (EHR) and electronic medical records (EMR), are growing rapidly. EHR and EMR are collected from patients to record their basic information, lab tests, vital signs, cli...

(This article belongs to the Collection Reviews on Artificial Intelligence and Natural Language Processing in Medical Diagnostics)
  • Article
  • Open Access
6 Citations
3,799 Views
16 Pages

Thyroid Collision Tumors: The Presence of the Medullary Thyroid Carcinoma Component Negatively Influences the Prognosis

  • Ion Negura,
  • Victor Ianole,
  • Mihai Danciu,
  • Cristina Preda,
  • Diana Gabriela Iosep,
  • Radu Dănilă,
  • Alexandru Grigorovici and
  • Delia Gabriela Ciobanu Apostol

Thyroid collision tumors (TCTs) are rare pathological findings, representing <1% of thyroid cancers. This study aimed to compare the main pathological features of TCTs containing medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (P...

(This article belongs to the Special Issue Recent Advances in Thyroid Carcinoma)
  • Article
  • Open Access
9 Citations
6,203 Views
9 Pages

Head-to-Head Comparison of Nasopharyngeal, Oropharyngeal and Nasal Swabs for SARS-CoV-2 Molecular Testing

  • Kasper Daugaard Larsen,
  • Mads Mose Jensen,
  • Anne-Sophie Homøe,
  • Elisabeth Arndal,
  • Grethe Badsberg Samuelsen,
  • Anders Koch,
  • Xiaohui Chen Nielsen,
  • Preben Homøe and
  • Tobias Todsen

Nasopharyngeal swabs (NPS) are considered the gold standard for SARS-CoV-2 testing but are technically challenging to perform and associated with discomfort. Alternative specimens for viral testing, such as oropharyngeal swabs (OPS) and nasal swabs,...

(This article belongs to the Special Issue Diagnosis of Viral Respiratory Infections)
  • Article
  • Open Access
5 Citations
3,778 Views
14 Pages

Clinical Performance of Diagnostic Methods in Third Molar Teeth with Early Occlusal Caries

  • Nazan Kocak-Topbas,
  • Kıvanç Kamburoğlu,
  • Ayşe Tuğba Ertürk-Avunduk,
  • Mehmet Ozgur Ozemre,
  • Nejlan Eratam and
  • Esra Ece Çakmak

The aim of this study was to compare the diagnostic performance of clinical visual examination (ICDAS II), digital periapical radiography (PR), near infrared light transillumination (NIR-LT), and laser fluorescence (LF) to microcomputed tomography (M...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
6 Citations
4,675 Views
10 Pages

The purpose of this phantom study was to compare the accuracy, speed and technical performance of CT guided needle placement using a conventional technique versus a novel, gantry integrated laser guidance system for both an expert and a novice. A tot...

(This article belongs to the Section Medical Imaging and Theranostics)

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Diagnostics - ISSN 2075-4418