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Diagnostics, Volume 12, Issue 7

July 2022 - 264 articles

Cover Story: Myelodysplastic syndromes (MDSs) are clonal disorders characterized by ineffective hematopoiesis, resulting in cytopenias and a risk of developing acute myeloid leukemia. In addition to mutations affecting hematopoietic stem cells (HSCs), numerous studies have highlighted the role of the bone marrow microenvironment (BMME) in the development of MDSs. The mesenchymal niche represents a key component of the BMME. In this review, we discuss the role of the mesenchymal niche in the pathophysiology of MDS and provide an overview of currently available in vitro and in vivo models that can be used to study the effects of the mesenchymal niche on HSCs. View this paper
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Articles (264)

  • Article
  • Open Access
2,189 Views
10 Pages

Three-Dimensional Angiographic Characteristics versus Functional Stenosis Severity in Fractional and Coronary Flow Reserve Discordance: A DEFINE FLOW Sub Study

  • Valerie Stegehuis,
  • Jelmer Westra,
  • Coen Boerhout,
  • Martin Sejr-Hansen,
  • Ashkan Eftekhari,
  • Hernan Mejía-Renteria,
  • Maribel Cambero-Madera,
  • Niels Van Royen,
  • Hitoshi Matsuo and
  • Masafumi Nakayama
  • + 4 authors

Background: Coronary angiography alone is insufficient to identify lesions associated with myocardial ischemia that may benefit from revascularization. Coronary physiology parameters may improve clinical decision making in addition to coronary angiog...

  • Article
  • Open Access
2 Citations
1,929 Views
14 Pages

Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs

  • Miren Uriarte Ecenarro,
  • Daniel Useros,
  • Aranzazu Alfranca,
  • Reyes Tejedor,
  • Isidoro González-Alvaro and
  • Rosario García-Vicuña

This study aimed to analyze the factors that influence anti-citrullinated protein antibody (ACPA) titers in a seropositive early arthritis (EA) population under non-protocolized treatment with disease-modifying anti-rheumatic drugs (DMARDs). A total...

  • Review
  • Open Access
7 Citations
4,326 Views
11 Pages

Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may...

  • Article
  • Open Access
4 Citations
3,071 Views
13 Pages

Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study

  • Louis Arnould,
  • Déa Haddad,
  • Florian Baudin,
  • Pierre-Henry Gabrielle,
  • Marc Sarossy,
  • Alain M. Bron,
  • Behzad Aliahmad and
  • Catherine Creuzot-Garcher

The retinal vascular network fractal dimension (FD) could be a promising imaging biomarker. Our objective was to evaluate its repeatability and reproducibility in healthy eyes. A cross-sectional study was undertaken with young, healthy volunteers who...

  • Article
  • Open Access
2 Citations
2,694 Views
20 Pages

Multiple Sclerosis (MS) is a disease attacking the central nervous system. According to MS Atlas’s most recent statistics, there are more than 2.8 million people worldwide diagnosed with MS. Recently, studies started to explore machine learning...

  • Article
  • Open Access
15 Citations
4,555 Views
15 Pages

Episodic Memory in Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer’s Disease Dementia (ADD): Using the “Doors and People” Tool to Differentiate between Early aMCI—Late aMCI—Mild ADD Diagnostic Groups

  • Athanasios Chatzikostopoulos,
  • Despina Moraitou,
  • Magdalini Tsolaki,
  • Elvira Masoura,
  • Georgia Papantoniou,
  • Maria Sofologi,
  • Vasileios Papaliagkas,
  • Georgios Kougioumtzis and
  • Efthymios Papatzikis

Episodic memory is the type of memory that allows the recollection of personal experiences containing information on what has happened and, also, where and when it happened. Because of its sensitivity to neurodegenerative diseases and the aging of th...

  • Review
  • Open Access
28 Citations
8,639 Views
15 Pages

Transvaginal Ultrasound vs. Magnetic Resonance Imaging (MRI) Value in Endometriosis Diagnosis

  • Alexandra Baușic,
  • Ciprian Coroleucă,
  • Cătălin Coroleucă,
  • Diana Comandașu,
  • Roxana Matasariu,
  • Andrei Manu,
  • Francesca Frîncu,
  • Claudia Mehedințu and
  • Elvira Brătilă

(1) Background: Endometriosis is a widespread gynecological condition that causes chronic pelvic discomfort, dysmenorrhea, infertility, and impaired quality of life in women of reproductive age. Clinical examination, transvaginal ultrasonography (TVS...

  • Review
  • Open Access
16 Citations
18,836 Views
18 Pages

Ultrasound Imaging of Facial Vascular Neural Structures and Relevance to Aesthetic Injections: A Pictorial Essay

  • Wei-Ting Wu,
  • Ke-Vin Chang,
  • Hsiang-Chi Chang,
  • Chen-Hsiang Kuan,
  • Lan-Rong Chen,
  • Kamal Mezian,
  • Vincenzo Ricci and
  • Levent Özçakar

The facial and submental regions are supplied by complicated neurovascular networks; therefore, facial aesthetic injections may be associated with serious adverse events such as skin necrosis and blindness. Pre-injection localization of neurovascular...

  • Article
  • Open Access
6 Citations
2,662 Views
11 Pages

Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis

  • Filippo Lococo,
  • Dania Nachira,
  • Marco Chiappetta,
  • Jessica Evangelista,
  • Pierre Emmanuel Falcoz,
  • Enrico Ruffini,
  • Paul Van Schil,
  • Marco Scarci,
  • Jòzsef Furàk and
  • Francesco Sollitto
  • + 17 authors

Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma...

  • Article
  • Open Access
2 Citations
5,232 Views
14 Pages

A Simple, Cost-Effective, and Extraction-Free Molecular Diagnostic Test for Sickle Cell Disease Using a Noninvasive Buccal Swab Specimen for a Limited-Resource Setting

  • Priya Thakur,
  • Pragya Gupta,
  • Nupur Bhargava,
  • Rajat Soni,
  • Narendra Varma Gottumukkala,
  • Sangam Giri Goswami,
  • Gaurav Kharya,
  • Vinodh Saravanakumar,
  • Padma Gunda and
  • Suman Jain
  • + 3 authors

Sickle cell disease (SCD) is the most prevalent life-threatening blood monogenic disorder. Currently, there is no cure available, apart from bone marrow transplantation. Early and efficient diagnosis of SCD is key to disease management, which would m...

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Diagnostics - ISSN 2075-4418