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Volume 12
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10.3390/diagnostics12071772
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Review

Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms

by
Lai-San Wong
1 and
Yu-Ta Yen
2,3,*
1
Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
2
Department of Dermatology, Fooying University Hospital, Pentong 928, Taiwan
3
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80420, Taiwan
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(7), 1772; https://doi.org/10.3390/diagnostics12071772
Submission received: 13 June 2022 / Revised: 5 July 2022 / Accepted: 20 July 2022 / Published: 21 July 2022
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Rheumatic Diseases)
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Abstract

Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their quality of life. However, it is rarely recognized both by patients and physicians. Meanwhile, pruritus is not only a symptom but is also related to the disease severity of some ACTDs. The pathophysiology of ACTD related pruritus is ambiguous. This review summarizes the features and possible mechanisms of ACTD-related pruritus, which might lead to proper diagnosis and treatment.
Keywords: autoimmune diseases; pruritus; small fiber neuropathy autoimmune diseases; pruritus; small fiber neuropathy

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MDPI and ACS Style

Wong, L.-S.; Yen, Y.-T. Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms. Diagnostics 2022, 12, 1772. https://doi.org/10.3390/diagnostics12071772

AMA Style

Wong L-S, Yen Y-T. Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms. Diagnostics. 2022; 12(7):1772. https://doi.org/10.3390/diagnostics12071772

Chicago/Turabian Style

Wong, Lai-San, and Yu-Ta Yen. 2022. "Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms" Diagnostics 12, no. 7: 1772. https://doi.org/10.3390/diagnostics12071772

APA Style

Wong, L.-S., & Yen, Y.-T. (2022). Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms. Diagnostics, 12(7), 1772. https://doi.org/10.3390/diagnostics12071772

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