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Diagnostics, Volume 11, Issue 6

June 2021 - 215 articles

Cover Story: Primary ciliary dyskinesia is a disorder that affects motile cilia in the airway, and confirmation of a diagnosis commonly relies on the assessment of ciliary ultrastructure by transmission electron microscopy. Heavy metal staining is required to provide contrast when imaging cilia, and one of the most used stains is uranyl acetate. Uranyl acetate is radioactive and, due to growing safety concerns and restrictions, we show that UA zero provides a high contrast and is a suitable replacement for the diagnosis of primary ciliary dyskinesia. View this paper
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Articles (215)

  • Article
  • Open Access
6 Citations
3,561 Views
10 Pages

Arterial Digital Pulse Photoplethysmography in Patients with Suspected Thoracic Outlet Syndrome: A Study of the “Ca+Pra” Maneuver

  • Jeanne Hersant,
  • Pierre Ramondou,
  • Francine Thouveny,
  • Mickael Daligault,
  • Mathieu Feuilloy,
  • Patrick Saulnier,
  • Pierre Abraham and
  • Samir Henni

The level of pulse amplitude (PA) change in arterial digital pulse plethysmography (A-PPG) that should be used to diagnose thoracic outlet syndrome (TOS) is debated. We hypothesized that a modification of the Roos test (by moving the arms forward, mi...

  • Article
  • Open Access
6 Citations
2,519 Views
16 Pages

We have investigated glycoconjugates sialization profile, endogen synthesis rate of antiganglioside antibodies (AGA), IL-6 signaling pathways correlated with activity disease in systemic lupus erythematous (SLE) and lupus nephritis (LN). Material and...

  • Article
  • Open Access
20 Citations
4,187 Views
12 Pages

High-Resolution Optical Coherence Tomography Angiography Characteristics of Limbal Stem Cell Deficiency

  • Shobhit Varma,
  • Swapna S. Shanbhag,
  • Pragnya Rao Donthineni,
  • Dilip Kumar Mishra,
  • Vivek Singh and
  • Sayan Basu

This study aimed to identify the anterior segment high-resolution optical coherence tomography (HR-OCT) and HR-OCT angiography (HR-OCTA) features suggestive of limbal stem cell deficiency (LSCD) as confirmed by both impression cytology (IC) and in vi...

  • Communication
  • Open Access
5 Citations
2,651 Views
6 Pages

Usefulness of BATF3 Immunohistochemistry in Diagnosing Classical Hodgkin Lymphoma

  • Julian Benckendorff,
  • Johanna Kuchar,
  • Frank Leithäuser,
  • Malena Zahn and
  • Peter Möller

It is well recognized that the AP-1 transcription factor BATF3 is constitutively expressed in Hodgkin/Reed-Sternberg (HRS) cells, but its potential as a diagnostic marker for classical Hodgkin lymphoma (cHL) has not yet been addressed. In this study,...

  • Review
  • Open Access
28 Citations
6,808 Views
24 Pages

International HIV Dementia Scale for HIV-Associated Neurocognitive Disorders: A Systematic Review and Meta-Analysis

  • Elena Cecilia Rosca,
  • Philippe Tadger,
  • Amalia Cornea,
  • Raluca Tudor,
  • Cristian Oancea and
  • Mihaela Simu

The present study aims to systematically review the evidence on the accuracy of the International HIV Dementia Scale (IHDS) test for diagnosing human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) and outline the quality and...

  • Article
  • Open Access
4 Citations
3,209 Views
11 Pages

Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study

  • Ute Lina Fahlenkamp,
  • Jan Kunkel,
  • Katharina Ziegeler,
  • Konrad Neumann,
  • Lisa Christine Adams,
  • Günther Engel,
  • Sarah Maria Böker and
  • Marcus Richard Makowski

MR relaxometry increasingly contributes to liver imaging. Studies on native relaxation times mainly describe relation to the presence of fibrosis. The hypothesis was that relaxation times are also influenced by other inherent factors, including chang...

  • Article
  • Open Access
28 Citations
5,307 Views
12 Pages

Cytohistological Correlation in Pleural Effusions Based on the International System for Reporting Serous Fluid Cytopathology

  • Daniel Pinto,
  • Eduardo Cruz,
  • Diamantina Branco,
  • Cláudia Linares,
  • Conceição Carvalho,
  • Amélia Silva,
  • Martinha Chorão and
  • Fernando Schmitt

The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS...

  • Article
  • Open Access
18 Citations
2,897 Views
10 Pages

Development and Verification of a Deep Learning Algorithm to Evaluate Small-Bowel Preparation Quality

  • Ji Hyung Nam,
  • Dong Jun Oh,
  • Sumin Lee,
  • Hyun Joo Song and
  • Yun Jeong Lim

Capsule endoscopy (CE) quality control requires an objective scoring system to evaluate the preparation of the small bowel (SB). We propose a deep learning algorithm to calculate SB cleansing scores and verify the algorithm’s performance. A 5-point s...

  • Review
  • Open Access
44 Citations
7,400 Views
17 Pages

Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives

  • Bakr Ahmed Taha,
  • Yousif Al Mashhadany,
  • Nur Nadia Bachok,
  • Ahmad Ashrif A Bakar,
  • Mohd Hadri Hafiz Mokhtar,
  • Mohd Saiful Dzulkefly Bin Zan and
  • Norhana Arsad

The propagation of viruses has become a global threat as proven through the coronavirus disease (COVID-19) pandemic. Therefore, the quick detection of viral diseases and infections could be necessary. This study aims to develop a framework for virus...

  • Article
  • Open Access
18 Citations
6,432 Views
12 Pages

Atypical Ductal Hyperplasia after Vacuum-Assisted Breast Biopsy: Can We Reduce the Upgrade to Breast Cancer to an Acceptable Rate?

  • Luca Nicosia,
  • Antuono Latronico,
  • Francesca Addante,
  • Rossella De Santis,
  • Anna Carla Bozzini,
  • Marta Montesano,
  • Samuele Frassoni,
  • Vincenzo Bagnardi,
  • Giovanni Mazzarol and
  • Enrico Cassano
  • + 3 authors

(1) Background: to evaluate which factors can reduce the upgrade rate of atypical ductal hyperplasia (ADH) to in situ or invasive carcinoma in patients who underwent vacuum-assisted breast biopsy (VABB) and subsequent surgical excision. (2) Methods:...

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Diagnostics - ISSN 2075-4418