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Diagnostics, Volume 11, Issue 2

February 2021 - 235 articles

Cover Story: Metabolic acidosis is a common disorder in CKD patients. Under physiological conditions, arterial bicarbonate level is higher in arterial than in venous blood due to the production of endogenous acids in tissues. In the lungs, bicarbonate is regenerated. We found that arteriovenous gradient of bicarbonate (AVΔ-HCO3−) positively correlated with eGFR. In patients with advanced CKD, there is practically no arteriovenous difference in bicarbonate concentration. The value of AVΔ-HCO3− may facilitate decision of bicarbonate supplementation or renal replacement therapy start in doubtful situations. View this paper.
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Articles (235)

  • Review
  • Open Access
27 Citations
4,577 Views
38 Pages

22 February 2021

This article presents a systematic literature review that expands and updates a previous review on the application of machine learning to laboratory medicine. We used Scopus and PubMed to collect, select and analyse the papers published from 2017 to...

  • Article
  • Open Access
28 Citations
6,483 Views
11 Pages

Comparison of Lung Ultrasound versus Chest X-ray for Detection of Pulmonary Infiltrates in COVID-19

  • María Mateos González,
  • Gonzalo García de Casasola Sánchez,
  • Francisco Javier Teigell Muñoz,
  • Kevin Proud,
  • Davide Lourdo,
  • Julia-Verena Sander,
  • Gabriel E. Ortiz Jaimes,
  • Michael Mader,
  • Jesús Canora Lebrato and
  • Marcos I. Restrepo
  • + 1 author

22 February 2021

Point-of-care lung ultrasound (LUS) is an attractive alternative to chest X-ray (CXR), but its diagnostic accuracy compared to CXR has not been well studied in coronavirus disease 2019 (COVID-19) patients. We conducted a prospective observational stu...

  • Article
  • Open Access
17 Citations
3,744 Views
12 Pages

Deformation Parameters of the Heart in Endurance Athletes and in Patients with Dilated Cardiomyopathy—A Cardiac Magnetic Resonance Study

  • Łukasz A. Małek,
  • Łukasz Mazurkiewicz,
  • Mikołaj Marszałek,
  • Marzena Barczuk-Falęcka,
  • Jenny E. Simon,
  • Jacek Grzybowski,
  • Barbara Miłosz-Wieczorek,
  • Marek Postuła and
  • Magdalena Marczak

22 February 2021

A better understanding of the left ventricle (LV) and right ventricle (RV) functioning would help with the differentiation between athlete’s heart and dilated cardiomyopathy (DCM). We aimed to analyse deformation parameters in endurance athletes rela...

  • Review
  • Open Access
9 Citations
3,332 Views
11 Pages

22 February 2021

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant form of gastrointestinal tumor and is the fourth leading cause of deaths due to cancer in Japan. This cancer shows a poor outcome due to the difficulty of its early diagnosis and its rapid...

  • Article
  • Open Access
12 Citations
3,848 Views
15 Pages

22 February 2021

This work is devoted to the development and manufacturing of realistic benchmark phantoms to evaluate the performance of microwave imaging devices. The 3D (3 dimensional) printed phantoms contain several cavities, designed to be filled with liquid so...

  • Review
  • Open Access
43 Citations
7,181 Views
24 Pages

Diagnosis of SARS-Cov-2 Infection by RT-PCR Using Specimens Other Than Naso- and Oropharyngeal Swabs: A Systematic Review and Meta-Analysis

  • Vânia M. Moreira,
  • Paulo Mascarenhas,
  • Vanessa Machado,
  • João Botelho,
  • José João Mendes,
  • Nuno Taveira and
  • M. Gabriela Almeida

21 February 2021

The rapid and accurate testing of SARS-CoV-2 infection is still crucial to mitigate, and eventually halt, the spread of this disease. Currently, nasopharyngeal swab (NPS) and oropharyngeal swab (OPS) are the recommended standard sampling techniques,...

  • Review
  • Open Access
4 Citations
7,714 Views
11 Pages

21 February 2021

In chronic obstructive pulmonary disease (COPD), exertional dyspnea, which increases with the disease’s progression, reduces exercise tolerance and limits physical activity, leading to a worsening prognosis. It is necessary to understand the diverse...

  • Article
  • Open Access
10 Citations
4,005 Views
11 Pages

Zinc Protoporphyrin Is a Reliable Marker of Functional Iron Deficiency in Patients with Inflammatory Bowel Disease

  • Eleni Leventi,
  • Aysegül Aksan,
  • Carl Thomas Nebe,
  • Jürgen Stein and
  • Karima Farrag

21 February 2021

Iron deficiency (ID) is a common manifestation of inflammatory bowel disease (IBD), arising primarily due to chronic inflammation and/or blood loss. There is no gold standard for ID diagnosis, which is often complicated by concomitant inflammation. Z...

  • Article
  • Open Access
20 Citations
5,790 Views
9 Pages

Postural Assessment Scale for Stroke Patients in Acute, Subacute and Chronic Stage: A Construct Validity Study

  • Cecilia Estrada-Barranco,
  • Roberto Cano-de-la-Cuerda,
  • Vanesa Abuín-Porras and
  • Francisco Molina-Rueda

21 February 2021

(1) Background: Observational scales are the most common methodology used to assess postural control and balance in people with stroke. The aim of this paper was to analyse the construct validity of the Postural Assessment Scale for Stroke Patients (...

  • Review
  • Open Access
25 Citations
2,796 Views
15 Pages

Inhibition of Androgen Signalling Improves the Outcomes of Therapies for Bladder Cancer: Results from a Systematic Review of Preclinical and Clinical Evidence and Meta-Analysis of Clinical Studies

  • Massimiliano Creta,
  • Giuseppe Celentano,
  • Luigi Napolitano,
  • Roberto La Rocca,
  • Marco Capece,
  • Gianluigi Califano,
  • Claudia Collà Ruvolo,
  • Francesco Mangiapia,
  • Simone Morra and
  • Carmine Turco
  • + 5 authors

20 February 2021

Bladder cancer (BCa) is an endocrine-related tumour and the activation of androgen signalling pathways may promote bladder tumorigenesis. We summarized the available preclinical and clinical evidence on the implications of the manipulation of androge...

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Diagnostics - ISSN 2075-4418