Skip to Content

Diagnostics, Volume 10, Issue 12

2020 December - 122 articles

Cover Story: Foot ulcers are a severe complication of diabetes mellitus. Laser speckle contrast imaging (LSCI) is a promising approach for diagnosis and prognosis. However, manual assessment during analysis of LSCI limits clinical applicability. An algorithm for semi-automatic analysis of LSCI data was developed and validated. We observed good to excellent agreement between the algorithm and manual assessment of the LSCI data. The algorithm delivers assessment of diabetic foot ulcers with a 10-fold workload reduction. This enhances the clinical applicability of LSCI for assessment of diabetic foot ulcers. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (122)

  • Article
  • Open Access
3 Citations
3,883 Views
14 Pages

Carotid Artery Plaque Identification and Display System (MRI-CAPIDS) Using Opensource Tools

  • Felipe P. Vista,
  • Minh Tri Ngo,
  • Seung Bin Cho,
  • Hyo Sung Kwak and
  • Kil To Chong

21 December 2020

Magnetic resonance imaging (MRI) represents one modality in atherosclerosis risk assessment, by permitting the classification of carotid plaques into either high- or low-risk lesions. Although MRI is generally used for observing the impact of atheros...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
16 Citations
12,852 Views
11 Pages

Right Heart Size and Right Ventricular Reserve in Pulmonary Hypertension: Impact on Management and Prognosis

  • Ekkehard Grünig,
  • Christina A. Eichstaedt,
  • Rebekka Seeger and
  • Nicola Benjamin

21 December 2020

Various parameters reflecting right heart size, right ventricular function and capacitance have been shown to be prognostically important in patients with pulmonary hypertension (PH). In the advanced disease, patients suffer from right heart failure,...

(This article belongs to the Special Issue Pulmonary Hypertension: Diagnosis and Management)
  • Article
  • Open Access
25 Citations
7,309 Views
15 Pages

Deep Learning Assisted Localization of Polycystic Kidney on Contrast-Enhanced CT Images

  • Djeane Debora Onthoni,
  • Ting-Wen Sheng,
  • Prasan Kumar Sahoo,
  • Li-Jen Wang and
  • Pushpanjali Gupta

21 December 2020

Total Kidney Volume (TKV) is essential for analyzing the progressive loss of renal function in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Conventionally, to measure TKV from medical images, a radiologist needs to localize and segment the k...

(This article belongs to the Special Issue Deep Learning for Computer-Aided Diagnosis in Biomedical Imaging)
  • Interesting Images
  • Open Access
7 Citations
3,841 Views
6 Pages

Usefulness of 18f-FDG PET-CT in Staging, Restaging, and Response Assessment in Pediatric Rhabdomyosarcoma

  • Davide Donner,
  • Paola Feraco,
  • Linda Meneghello,
  • Barbara Rombi,
  • Lorena Picori and
  • Franca Chierichetti

21 December 2020

Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Despite clinical advances, subsets of these patients continue to suffer high morbidity and mortality rates associated with their disease. Following the European guidelines for 18F-...

(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
  • Case Report
  • Open Access
6 Citations
3,054 Views
5 Pages

Dual TMPRSS2:ERG Fusion in a Patient with Lung and Prostate Cancers

  • Francesca Giunchi,
  • Francesco Massari,
  • Annalisa Altimari,
  • Elisa Gruppioni,
  • Elisabetta Nobili,
  • Michelangelo Fiorentino and
  • Andrea Ardizzoni

20 December 2020

The TMPRSS2:ERG fusion is considered prostate specific and has been rarely described in other tumors. We describe the case of a patient who developed lung and prostate cancers, both harboring the TMPRSS2:ERG fusion. The patient developed a cancer of...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
7 Citations
4,139 Views
15 Pages

Prognostic Value of Admission Chest CT Findings for Invasive Ventilation Therapy in COVID-19 Pneumonia

  • Eva Gresser,
  • Johannes Rueckel,
  • Daniel Puhr-Westerheide,
  • Vincent Schwarze,
  • Nicola Fink,
  • Wolfgang G. Kunz,
  • Dietmar Wassilowsky,
  • Michael Irlbeck,
  • Jens Ricke and
  • Bastian O. Sabel
  • + 1 author

19 December 2020

(1) Background: To assess the value of chest CT imaging features of COVID-19 disease upon hospital admission for risk stratification of invasive ventilation (IV) versus no or non-invasive ventilation (non-IV) during hospital stay. (2) Methods: A retr...

(This article belongs to the Collection Virus Diagnostic Methods and Techniques: Learning from the COVID-19 Global Outbreak)
  • Article
  • Open Access
31 Citations
4,883 Views
10 Pages

Failure of Lactate Clearance Predicts the Outcome of Critically Ill Septic Patients

  • Raphael Romano Bruno,
  • Bernhard Wernly,
  • Stephan Binneboessel,
  • Philipp Baldia,
  • Dragos Andrei Duse,
  • Ralf Erkens,
  • Malte Kelm,
  • Behrooz Mamandipoor,
  • Venet Osmani and
  • Christian Jung

18 December 2020

Purpose: Early lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a lactate clearance >0% might differ from patients with an inferior clearance in terms of intensive care management an...

(This article belongs to the Special Issue Multimodal Diagnostic Methods in Sepsis in the Critically Ill Patients)
  • Article
  • Open Access
7 Citations
3,843 Views
12 Pages

COPD Imaging on a 3rd Generation Dual-Source CT: Acquisition of Paired Inspiratory-Expiratory Chest Scans at an Overall Reduced Radiation Risk

  • Joshua Gawlitza,
  • Thomas Henzler,
  • Frederik Trinkmann,
  • Elke Nekolla,
  • Holger Haubenreisser and
  • Gunnar Brix

18 December 2020

As stated by the Fleischner Society, an additional computed tomography (CT) scan in expiration is beneficial in patients with chronic obstructive pulmonary disease (COPD). It was thus the aim of this study to evaluate the radiation risk of a state-of...

(This article belongs to the Special Issue Assessment of Radiation Dose in X-ray and CT Exams)
  • Article
  • Open Access
7 Citations
4,900 Views
12 Pages

Pericapillary Edema Assessment by Means of the Nailfold Capillaroscopy and Laser Scanning Microscopy

  • Boris P. Yakimov,
  • Yury I. Gurfinkel,
  • Denis A. Davydov,
  • Anastasia S. Allenova,
  • Gleb S. Budylin,
  • Vladimir Yu. Vasiliev,
  • Vera Yu. Soldatova,
  • Armais A. Kamalov,
  • Simon T. Matskeplishvili and
  • Evgeny A. Shirshin
  • + 1 author

18 December 2020

Edema, i.e., fluid accumulation in the interstitial space, accompanies numerous pathological states of the human organism, including heart failure (HF), inflammatory response, and lymphedema. Nevertheless, techniques for quantitative assessment of th...

(This article belongs to the Section Biomedical Optics)
  • Communication
  • Open Access
8 Citations
6,792 Views
6 Pages

17 December 2020

99mTc-dimercaptosuccinic acid (DMSA) scintigraphy is currently the method of choice for assessing renal scarring in children, but it is not established whether conducting the scan as a single photon emission tomography combined with low-dose CT (SPEC...

(This article belongs to the Collection Hybrid Imaging in Medicine)
  • Review
  • Open Access
27 Citations
6,022 Views
19 Pages

The Multifaceted Roles of MicroRNAs in Cystic Fibrosis

  • Fatima Domenica Elisa De Palma,
  • Valeria Raia,
  • Guido Kroemer and
  • Maria Chiara Maiuri

17 December 2020

Cystic fibrosis (CF) is a lifelong disorder affecting 1 in 3500 live births worldwide. It is a monogenetic autosomal recessive disease caused by loss-of-function mutations in the gene encoding the chloride channel cystic fibrosis transmembrane conduc...

(This article belongs to the Special Issue Diagnosis and Management of Cystic Fibrosis)
  • Article
  • Open Access
9 Citations
3,927 Views
12 Pages

Multimodality Approach for Endovascular Left Atrial Appendage Closure: Head-To-Head Comparison among 2D and 3D Echocardiography, Angiography, and Computer Tomography

  • Gianpiero Italiano,
  • Anna Maltagliati,
  • Valentina Mantegazza,
  • Laura Fusini,
  • Maria Elisabetta Mancini,
  • Alessio Gasperetti,
  • Denise Brusoni,
  • Francesca Susini,
  • Alberto Formenti and
  • Mauro Pepi
  • + 3 authors

17 December 2020

Background: Percutaneous left atrial appendage closure (LAAC) requires accurate pre- and intraprocedural measurements, and multimodality imaging is an essential tool for guiding the procedure. Two-dimensional (2D TOE) and three-dimensional (3D TOE) t...

(This article belongs to the Special Issue Trends and Novelties in Cardiovascular Imaging)
  • Article
  • Open Access
8 Citations
5,038 Views
15 Pages

17 December 2020

Monitoring of markers reflecting cardiac autonomic activity before and during stressful situations may be useful for identifying the physiological state of an athlete and may have medical or performance implications. The study aimed to determine grou...

(This article belongs to the Special Issue Diagnostic Challenges in Sports Cardiology)
  • Article
  • Open Access
6 Citations
3,355 Views
16 Pages

Heart Rate Influence on the QT Variability Risk Factors

  • Irena Andršová,
  • Katerina Hnatkova,
  • Martina Šišáková,
  • Ondřej Toman,
  • Peter Smetana,
  • Katharina M. Huster,
  • Petra Barthel,
  • Tomáš Novotný,
  • Georg Schmidt and
  • Marek Malik

16 December 2020

QT interval variability, mostly expressed by QT variability index (QTVi), has repeatedly been used in risk diagnostics. Physiologic correlates of QT variability expressions have been little researched especially when measured in short 10-second elect...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
9 Citations
3,171 Views
11 Pages

Nuclear Expression Loss of SSBP2 Is Associated with Poor Prognostic Factors in Colorectal Adenocarcinoma

  • Yumin Chung,
  • Hyunsung Kim,
  • Seongsik Bang,
  • Kiseok Jang,
  • Seung Sam Paik and
  • Su-Jin Shin

16 December 2020

Single-stranded DNA binding protein 2 (SSBP2) is involved in DNA damage response and may induce growth arrest in cancer cells, having a potent tumor suppressor role. SSBP2 is ubiquitously expressed and the loss of its expression has been reported in...

(This article belongs to the Collection Biomarkers in Medicine)
  • Review
  • Open Access
16 Citations
4,279 Views
13 Pages

16 December 2020

This study aimed to evaluate the radiologic response and adverse event rates of immune checkpoint inhibitor (ICI) therapy with or without radiotherapy for the treatment of non-small cell lung cancer (NSCLC) brain metastases. A systematic literature s...

(This article belongs to the Special Issue Systematic Review and Meta-Analysis of Imaging Biomarkers for Breakthrough Cancer Therapies)
  • Review
  • Open Access
15 Citations
13,432 Views
11 Pages

Exploring the Spectrum of Kidney Ciliopathies

  • Matteo Santoni,
  • Francesco Piva,
  • Alessia Cimadamore,
  • Matteo Giulietti,
  • Nicola Battelli,
  • Rodolfo Montironi,
  • Laura Cosmai and
  • Camillo Porta

16 December 2020

Ciliopathies are a group of multi-organ diseases caused by the disruption of the primary cilium. This event leads to a variety of kidney disorders, including nephronophthisis, renal cystic dysplasia, and renal cell carcinoma (RCC). Primary cilium con...

(This article belongs to the Special Issue Novel Diagnostic and Predictive Strategies in Renal Cell Tumors)
  • Review
  • Open Access
31 Citations
4,418 Views
24 Pages

Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas—A Systematic Review

  • Marek Mazurek,
  • Bartłomiej Kulesza,
  • Filip Stoma,
  • Jacek Osuchowski,
  • Sławomir Mańdziuk and
  • Radosław Rola

16 December 2020

Background: A very important aspect in the treatment of high-grade glioma is gross total resection to reduce the risk of tumor recurrence. One of the methods to facilitate this task is intraoperative fluorescence navigation. The aim of the study was...

(This article belongs to the Special Issue Brain Imaging/Neuroimaging)
  • Article
  • Open Access
13 Citations
3,549 Views
11 Pages

Neurocognitive Functioning and Suicidal Behavior in Violent Offenders with Schizophrenia Spectrum Disorders

  • Miriam Sánchez-Sansegundo,
  • Irene Portilla-Tamarit,
  • María Rubio-Aparicio,
  • Natalia Albaladejo-Blazquez,
  • Nicolás Ruiz-Robledillo,
  • Rosario Ferrer-Cascales and
  • Ana Zaragoza-Martí

15 December 2020

Suicide is one of the main premature causes of death in patients with schizophrenia. However, little is known about the relationship between neurocognitive functioning and suicidality in violent offenders with schizophrenia who have been sentenced to...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
33 Citations
6,075 Views
11 Pages

Can MRI Biomarkers Predict Triple-Negative Breast Cancer?

  • Giuliana Moffa,
  • Francesca Galati,
  • Emmanuel Collalunga,
  • Veronica Rizzo,
  • Endi Kripa,
  • Giulia D’Amati and
  • Federica Pediconi

15 December 2020

The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI...

(This article belongs to the Special Issue Advances in Breast MRI)
  • Review
  • Open Access
28 Citations
4,564 Views
12 Pages

Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities

  • Chiara Lazzari,
  • Alessandra Bulotta,
  • Maria Giulia Cangi,
  • Gabriele Bucci,
  • Lorenza Pecciarini,
  • Silvia Bonfiglio,
  • Vincenza Lorusso,
  • Stefania Ippati,
  • Gianluigi Arrigoni and
  • Vanesa Gregorc
  • + 2 authors

15 December 2020

Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients’ survival has significantly improved. A growing number of targetab...

(This article belongs to the Special Issue Lung Cancer Molecular Pathology)
  • Article
  • Open Access
1 Citations
5,901 Views
11 Pages

Introduction of a Simplified Psoriatic Arthritis Magnetic Resonance Imaging Score (sPsAMRIS): A Potential Tool for Treatment Monitoring in Peripheral Psoriatic Arthritis

  • Daniel B. Abrar,
  • Christoph Schleich,
  • Ralph Brinks,
  • Christine Goertz,
  • Miriam Frenken,
  • Matthias Schneider,
  • Sven Nebelung and
  • Philipp Sewerin

15 December 2020

Background: To evaluate whether a simplified (s) version of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS), sPsAMRIS, is a potential tool for therapy monitoring in psoriatic arthritis (PsA). Methods: Seventeen patients with active...

(This article belongs to the Special Issue Inflammatory and Infectious Bone and Joint Diseases: Diagnosis and Management)
  • Article
  • Open Access
2,978 Views
11 Pages

Simple Stepwise Approach to Differentiate Cyst-Like Soft-Tissue Masses by Using Time-Resolved Magnetic Resonance Angiography

  • Ying-Chieh Lai,
  • Yu-Hsiang Juan,
  • Shu-Hang Ng,
  • Tzu-Chin Lo,
  • Wen-Yu Chuang,
  • Chun-Chieh Chen,
  • Chi-Ting Liau,
  • Gigin Lin,
  • Yu-Jr Lin and
  • Yu-Ching Lin

15 December 2020

This retrospective study aimed to differentiate cyst-like musculoskeletal soft-tissue masses by using time-resolved magnetic resonance angiography (MRA). During May 2015 to November 2019, patients with cyst-like soft-tissue masses examined through co...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
2,906 Views
18 Pages

15 December 2020

The aim of the work was to study the features of the salivary biochemical composition in the combined pathology of lung cancer and chronic obstructive pulmonary disease (COPD) of varying severity (COPD I, COPD II). The study group included patients w...

(This article belongs to the Special Issue Diagnosis, Treatment, and Management of COPD and Asthma)
  • Article
  • Open Access
27 Citations
4,817 Views
9 Pages

Endoscopic Ultrasonography Diagnosis of Early Pancreatic Cancer

  • Keisuke Kurihara,
  • Keiji Hanada and
  • Akinori Shimizu

14 December 2020

Early diagnosis of pancreatic cancer (PC) can improve patients’ prognosis. We aimed to investigate the utility of endoscopic ultrasonography (EUS) for the early diagnosis of PC. This study included 64 patients with PC at an early stage treated...

(This article belongs to the Special Issue The Advanced Role of Diagnostic Endoscopic Ultrasonography)
  • Article
  • Open Access
8 Citations
5,657 Views
24 Pages

Simultaneous fMRI-EEG-Based Characterisation of NREM Parasomnia Disease: Methods and Limitations

  • Marek Piorecky,
  • Vlastimil Koudelka,
  • Eva Miletinova,
  • Jitka Buskova,
  • Jan Strobl,
  • Jiri Horacek,
  • Martin Brunovsky,
  • Stanislav Jiricek,
  • Jaroslav Hlinka and
  • Vaclava Piorecka
  • + 1 author

14 December 2020

Functional magnetic resonance imaging (fMRI) techniques and electroencephalography (EEG) were used to investigate sleep with a focus on impaired arousal mechanisms in disorders of arousal (DOAs). With a prevalence of 2–4% in adults, DOAs are si...

(This article belongs to the Special Issue Advanced Techniques in Body Magnetic Resonance Imaging)
  • Review
  • Open Access
63 Citations
7,683 Views
17 Pages

Cardiac Masses: The Role of Cardiovascular Imaging in the Differential Diagnosis

  • Constantina Aggeli,
  • Yannis Dimitroglou,
  • Leonidas Raftopoulos,
  • Georgia Sarri,
  • Sophie Mavrogeni,
  • Joyce Wong,
  • Eleftherios Tsiamis and
  • Costas Tsioufis

14 December 2020

Cardiac masses are space occupying lesions within the cardiac cavities or adjacent to the pericardium. They include frequently diagnosed clinical entities such as clots and vegetations, common benign tumors such as myxomas and papillary fibroelastoma...

(This article belongs to the Special Issue Advances in Cardiovascular Imaging 2021)
  • Article
  • Open Access
4 Citations
3,189 Views
15 Pages

14 December 2020

A total of 472 epilepsy patients with a 4-year remission period were divided into 10-year age groups according to age of onset. The relapse patterns during at least 3 years of follow-up were classified as early relapse (ER), late relapse (LR), and se...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
4 Citations
3,785 Views
11 Pages

Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition

  • Josefine Graef,
  • Carolin Senger,
  • Christoph Wetz,
  • Alexander D. J. Baur,
  • Anne K. Kluge,
  • Mathias Lukas,
  • Julian M. M. Rogasch,
  • Thula C. Walter-Rittel,
  • David Kohnert and
  • Christian Furth
  • + 6 authors

13 December 2020

Ga-68-DOTATOC-PET/MRI can affect the planning target volume (PTV) definition of meningiomas before radiosurgery. A shorter tracer uptake time before image acquisition could allow the examination of more patients. The aim of this study was to investig...

(This article belongs to the Special Issue Novel Theranostic Agents)
  • Article
  • Open Access
10 Citations
7,766 Views
11 Pages

Comparing Absorbable and Nonabsorbable Suture Materials for Repair of Achilles Tendon Rupture: A Magnetic Resonance Imaging-Based Study

  • Jaeho Cho,
  • Hyun-Joo Kim,
  • Jeong Seok Lee,
  • Jahyung Kim,
  • Sung Hun Won,
  • Young Yi and
  • Dong-Il Chun

13 December 2020

We aimed to compare magnetic resonance imaging (MRI) findings and corresponding clinical outcomes of repaired Achilles tendons using absorbable and nonabsorbable sutures. Patients who underwent Achilles tendon repair were divided into 2 groups, with...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
4,111 Views
14 Pages

Retrospective Definition of Clostridioides difficile PCR Ribotypes on the Basis of Whole Genome Polymorphisms: A Proof of Principle Study

  • Manisha Goyal,
  • Lysiane Hauben,
  • Hannes Pouseele,
  • Magali Jaillard,
  • Katrien De Bruyne,
  • Alex van Belkum and
  • Richard Goering

12 December 2020

Clostridioides difficile is a cause of health care-associated infections. The epidemiological study of C. difficile infection (CDI) traditionally involves PCR ribotyping. However, ribotyping will be increasingly replaced by whole genome sequencing (W...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
2,879 Views
14 Pages

12 December 2020

Postoperative swallowing, affected by general anesthesia and intubation, plays an important part in airway and oral intake safety regarding effective oropharyngeal and esophageal emptying. However, objective evidence is limited. This study aimed to d...

(This article belongs to the Special Issue Challenges and Advances in Monitoring and Diagnosis in Medical Sciences)
  • Article
  • Open Access
24 Citations
3,161 Views
9 Pages

CRMS/CFSPID Subjects Carrying D1152H CFTR Variant: Can the Second Variant Be a Predictor of Disease Development?

  • Vito Terlizzi,
  • Rita Padoan,
  • Laura Claut,
  • Carla Colombo,
  • Benedetta Fabrizzi,
  • Marco Lucarelli,
  • Sabina Maria Bruno,
  • Alice Castaldo,
  • Paolo Bonomi and
  • Antonella Tosco
  • + 1 author

12 December 2020

Background: There are no predictive factors of evolution of cystic fibrosis (CF) screen positive inconclusive diagnosis subjects (CFSPIDs). Aim: to define the role of the second CFTR variant as a predictive factor of disease evolution in CFSPIDs carr...

(This article belongs to the Special Issue Diagnosis and Management of Cystic Fibrosis)
  • Article
  • Open Access
43 Citations
5,002 Views
14 Pages

Comparison of Various Obesity-Related Indices for Identification of Metabolic Syndrome: A Population-Based Study from Taiwan Biobank

  • Tai-Hua Chiu,
  • Ya-Chin Huang,
  • Hsuan Chiu,
  • Pei-Yu Wu,
  • Hsin-Ying Clair Chiou,
  • Jiun-Chi Huang and
  • Szu-Chia Chen

12 December 2020

This study aimed to evaluate the performance of 11 obesity-related indices, including body mass index (BMI), waist circumference, waist-to-height ratio, waist–hip ratio, a body shape index, abdominal volume index, body adiposity index, body rou...

(This article belongs to the Special Issue Diagnosis and Management of Obesity, Eating and Weight-Related Disorders)
  • Article
  • Open Access
4 Citations
4,189 Views
14 Pages

A Light-Sheet-Based Imaging Spectrometer to Characterize Acridine Orange Fluorescence within Leukocytes

  • Amy J. Powless,
  • Sandra P. Prieto,
  • Madison R. Gramling,
  • Jingyi Chen and
  • Timothy J. Muldoon

12 December 2020

Low-cost imaging systems that utilize exogenous fluorescent dyes, such as acridine orange (AO), have recently been developed for use as point-of-care (POC) blood analyzers. AO-based fluorescence imaging exploits variations in emission wavelength with...

(This article belongs to the Section Biomedical Optics)
  • Review
  • Open Access
43 Citations
9,020 Views
31 Pages

The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

  • Virginia Liberini,
  • Martin W. Huellner,
  • Serena Grimaldi,
  • Monica Finessi,
  • Philippe Thuillier,
  • Alfredo Muni,
  • Riccardo E. Pellerito,
  • Mauro G. Papotti,
  • Alessandro Piovesan and
  • Désirée Deandreis
  • + 1 author

12 December 2020

The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT respon...

(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
  • Case Report
  • Open Access
8 Citations
4,270 Views
15 Pages

Ovarian Carcinosarcoma with Retroperitoneal Para-Aortic Lymph Node Dissemination Followed by an Unusual Postoperative Complication: A Case Report with a Brief Literature Review

  • Stoyan Kostov,
  • Yavor Kornovski,
  • Yonka Ivanova,
  • Deyan Dzhenkov,
  • George Stoyanov,
  • Stanislav Stoilov,
  • Stanislav Slavchev,
  • Ekaterina Trendafilova and
  • Angel Yordanov

11 December 2020

Introduction. Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumour (MMMT), is one of the rarest histological subtypes of ovarian cancer. It is an aggressive tumour with a dismal prognosis—the median survival of pati...

(This article belongs to the Special Issue Ovarian Cancer 3.0: Characteristics, Screening, Diagnosis and Treatment)
  • Article
  • Open Access
6 Citations
3,846 Views
16 Pages

Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

  • Masliza Hanuni Mat Ali,
  • Tuan Salwani Tuan Ismail,
  • Wan Norlina Wan Azman,
  • Najib Majdi Yaacob,
  • Norhayati Yahaya,
  • Nani Draman,
  • Wan Mohd Izani Wan Mohamed,
  • Mohd Shafie Abdullah,
  • Hanim Afzan Ibrahim and
  • Mafauzy Mohamed
  • + 1 author

11 December 2020

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
9 Citations
3,036 Views
10 Pages

The Influence of Calcification Factors and Endothelial-Dysfunction Factors on the Development of Unstable Atherosclerotic Plaques

  • Yana V. Polonskaya,
  • Elena V. Kashtanova,
  • Ivan S. Murashov,
  • Aleksei V. Kurguzov,
  • Evgeny V. Sadovski,
  • Nikolay A. Maslatsov,
  • Ekaterina M. Stakhneva,
  • Alexander M. Chernyavskii and
  • Yuliya I. Ragino

11 December 2020

Background: This study aimed to evaluate changes in markers of calcification and of endothelial dysfunction during the development of calcification and instability of atherosclerotic plaques and to identify associations of calcification factors with...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
47 Citations
7,502 Views
22 Pages

11 December 2020

Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma that primarily arises in the brain, spinal cord, leptomeninges, and vitreoretinal compartment of the eye. The term is sometimes used interchangeably wit...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
9 Citations
3,342 Views
15 Pages

The Activation of Prothrombin Seems to Play an Earlier Role than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation

  • Maider Beitia,
  • Paolo Romano,
  • Gorka Larrinaga,
  • Jon Danel Solano-Iturri,
  • Annalisa Salis,
  • Gianluca Damonte,
  • Marco Bruzzone,
  • Marcello Ceppi and
  • Aldo Profumo

11 December 2020

Colorectal cancer (CRC) is the second cause of death in men and the third in women. This work deals with the study of the low molecular weight protein fraction of sera from patients who underwent surgery for CRC and who were followed for several year...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Case Report
  • Open Access
6 Citations
3,102 Views
8 Pages

Dysgerminoma with a Somatic Exon 17 KIT Mutation and SHH Pathway Activation in a Girl with Turner Syndrome

  • Ada Gawrychowska,
  • Ewa Iżycka-Świeszewska,
  • Beata S. Lipska-Ziętkiewicz,
  • Dominika Kuleszo,
  • Joanna Bautembach-Minkowska,
  • Marcin Łosin and
  • Joanna Stefanowicz

10 December 2020

This article reports a case of a 7-year-old girl with Turner syndrome, treated with growth hormone (GH), who developed ovarian dysgerminoma. The patient karyotype was mosaic for chromosome Xq deletion: 46,X,del(X)(q22)/45,X. No Y chromosome sequences...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
11 Citations
3,197 Views
13 Pages

Cone-Beam CT-Guided Lung Biopsies: Results in 94 Patients

  • Daniel Gulias-Soidan,
  • Nilfa Milena Crus-Sanchez,
  • Daniel Fraga-Manteiga,
  • Juan Ignacio Cao-González,
  • Vanesa Balboa-Barreiro and
  • Cristina González-Martín

10 December 2020

Background: The aim of this study was to evaluate the diagnostic capacity of Cone-Beam computed tomography (CT)-guided transthoracic percutaneous biopsies on lung lesions in our setting and to detect risk factors for possible complications. Methods:...

(This article belongs to the Special Issue Percutaneous Imaging-Guided Techniques in Interventional Oncology)
  • Article
  • Open Access
5 Citations
9,016 Views
18 Pages

A Novel Earwax Method to Measure Acute and Chronic Glucose Levels

  • Andrés Herane-Vives,
  • Susana Espinoza,
  • Rodrigo Sandoval,
  • Lorena Ortega,
  • Luis Alameda,
  • Allan H. Young,
  • Danilo Arnone,
  • Alexander Hayes and
  • Jan Benöhr

10 December 2020

Diabetes is the fourth cause of death globally. To date, there is not a practical, as well as an accurate sample for reflecting chronic glucose levels. We measured earwax glucose in 37 controls. Participants provided standard serum, glycated hemoglob...

(This article belongs to the Special Issue Challenges and Advances in Monitoring and Diagnosis in Medical Sciences)
  • Article
  • Open Access
16 Citations
6,307 Views
15 Pages

Post-Mortem Diagnosis and Autopsy Findings in SARS-CoV-2 Infection: Forensic Case Series

  • Arthur-Atilla Keresztesi,
  • Filip Perde,
  • Andreea Ghita-Nanu,
  • Carmen-Corina Radu,
  • Mihai Negrea and
  • Gabriela Keresztesi

10 December 2020

Towards the end of 2019, a novel coronavirus was identified as the culprit for a cluster of pneumonia cases in Wuhan, China. Since then, it has rapidly spread worldwide, affecting more than 43 million people, and in March 2020, the World Health Organ...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Case Report
  • Open Access
4 Citations
3,244 Views
9 Pages

Implantation of a Dual-Chamber Automatic Cardioverter Defibrillator in a Patient with Persistent Left Superior Vena Cava: Case Report and Brief Literature Review

  • Mihai Cristian Haba,
  • Andreea Maria Ursaru,
  • Antoniu Octavian Petriș,
  • Ștefan Eduard Popescu and
  • Nicolae Dan Tesloianu

10 December 2020

Persistence of the left superior vena cava (PLSVC) is a congenital anomaly reported in 0.3–0.5% of patients. Due to the multiple and complex anatomical variations, transvenous lead placement can become challenging. We report the case of a 47-ye...

(This article belongs to the Special Issue Imaging Cardiac Arrhythmia/Sudden Cardiac Death)
  • Article
  • Open Access
6 Citations
3,023 Views
14 Pages

Diagnostic Performance of Different Simulated Low-Dose Levels in Patients with Suspected Cervical Abscess Using a Third-Generation Dual-Source CT Scanner

  • Moritz T. Winkelmann,
  • Saif Afat,
  • Sven S. Walter,
  • Eva Stock,
  • Vincent Schwarze,
  • Andreas Brendlin,
  • Manuel Kolb,
  • Christoph P. Artzner and
  • Ahmed E. Othman

10 December 2020

The aim of this study was to investigate the effects of dose reduction on diagnostic accuracy and image quality of cervical computed tomography (CT) in patients with suspected cervical abscess. Forty-eight patients (mean age 45.5 years) received a CT...

(This article belongs to the Special Issue Assessment of Radiation Dose in X-ray and CT Exams)
  • Review
  • Open Access
40 Citations
4,776 Views
30 Pages

9 December 2020

Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all cell types in physiological and pathological states. In hematological malignancies, tumor-derived EVs are critical players in mediating intercellular commu...

(This article belongs to the Special Issue Diagnostic Potential of Extracellular Vesicles (EVs) in Chronic Diseases)
  • Article
  • Open Access
6 Citations
2,918 Views
14 Pages

Evaluation of Parameters for Estimating the Postmortem Interval of Skeletal Remains Using Bovine Femurs: A Pilot Study

  • Midori Nagai,
  • Koichi Sakurada,
  • Kazuhiko Imaizumi,
  • Yoshinori Ogawa,
  • Motohiro Uo,
  • Takeshi Funakoshi and
  • Koichi Uemura

9 December 2020

The postmortem interval (PMI) of victims is a key parameter in criminal investigations. However, effective methods for estimating the PMI of skeletal remains have not been established because it is determined by various factors, including environment...

(This article belongs to the Special Issue Progress in the Forensic Diagnosis)
  • Article
  • Open Access
16 Citations
4,071 Views
22 Pages

Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis

  • Shangbin Cui,
  • Zhiyu Zhou,
  • Xizhe Liu,
  • Robert Geoff Richards,
  • Mauro Alini,
  • Songlin Peng,
  • Shaoyu Liu,
  • Xuenong Zou,
  • Zhen Li and
  • Sibylle Grad

8 December 2020

Circulating microRNAs (miRNAs) have been associated with various degenerative diseases, including intervertebral disc (IVD) degeneration. Lumbar disc herniation (LDH) often occurs in young patients, although the underlying mechanisms are poorly under...

(This article belongs to the Section Pathology and Molecular Diagnostics)

of 3

XFacebookLinkedIn
Diagnostics - ISSN 2075-4418