Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study

Bel’skaya, Lyudmila V.; Sarf, Elena A.; Solomatin, Denis V.; Kosenok, Victor K.

doi:10.3390/diagnostics10121095

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Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study

Lyudmila V. Bel’skaya

^1,*

Elena A. Sarf

¹,

Denis V. Solomatin

² and

Victor K. Kosenok

Biochemistry Research Laboratory, Omsk State Pedagogical University, 14, Tukhachevsky str, 644043 Omsk, Russia

Department of Mathematics and Mathematics Teaching Methods, Omsk State Pedagogical University, 14, Tukhachevsky str, 644043 Omsk, Russia

Department of Oncology, Omsk State Medical University, 12, Lenina str, 644099 Omsk, Russia

Author to whom correspondence should be addressed.

Diagnostics 2020, 10(12), 1095; https://doi.org/10.3390/diagnostics10121095

Received: 14 November 2020 / Revised: 10 December 2020 / Accepted: 14 December 2020 / Published: 15 December 2020

(This article belongs to the Special Issue Diagnosis, Treatment, and Management of COPD and Asthma)

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Abstract

The aim of the work was to study the features of the salivary biochemical composition in the combined pathology of lung cancer and chronic obstructive pulmonary disease (COPD) of varying severity (COPD I, COPD II). The study group included patients with lung cancer (n = 392), non-malignant lung pathologies (n = 168) and healthy volunteers (n = 500). Before treatment, the salivary biochemical composition was determined according to 34 indicators. Survival analysis performed by the Kaplan-Meier method. Biochemical parameters (catalase, imidazole compounds ICs, sialic acids, lactate dehydrogenase (LDH)) that can be used to monitor patients at risk (COPD I) for timely diagnosis of lung cancer are determined. A complex of salivary biochemical indicators with prognostic value in lung cancer was revealed. For patients with lung cancer without COPD, a group of patients with a favorable prognosis can be distinguished with a combination of ICs < 0.478 mmol/L and LDH >1248 U/L (HR = 1.56, 95% CI 0.40–6.07, p = 0.03891). For COPD I, a level of ICs < 0.182 mmol/L are prognostically favorable (HR = 1.74, 95% CI 0.71–4.21, p = 0.07270). For COPD II, combinations of pH < 6.74 and LDH >1006 U/L are prognostically favorable. In general, for patients with lung cancer in combination with COPD I, the prognosis is more favorable than without COPD. View Full-Text

Keywords: lung cancer; chronic obstructive pulmonary disease; saliva; biochemistry; diagnostics; prognosis

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MDPI and ACS Style

Bel’skaya, L.V.; Sarf, E.A.; Solomatin, D.V.; Kosenok, V.K. Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study. Diagnostics 2020, 10, 1095. https://doi.org/10.3390/diagnostics10121095

AMA Style

Bel’skaya LV, Sarf EA, Solomatin DV, Kosenok VK. Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study. Diagnostics. 2020; 10(12):1095. https://doi.org/10.3390/diagnostics10121095

Chicago/Turabian Style

Bel’skaya, Lyudmila V., Elena A. Sarf, Denis V. Solomatin, and Victor K. Kosenok. 2020. "Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study" Diagnostics 10, no. 12: 1095. https://doi.org/10.3390/diagnostics10121095

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Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study

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