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Life, Volume 13, Issue 4

April 2023 - 213 articles

Cover Story: Despite the improvements in the timely revascularization of acute myocardial infarction, many patients still develop adverse ventricular remodeling and progress to heart failure. In recent years, new pharmacological therapies have emerged for the treatment of HF, including revolutionary drugs such as sodium-glucose cotransporter-2 inhibitors and angiotensin receptor-neprilysin inhibitors, which promote reverse remodeling. Cardiac resynchronization therapy, cardiac contractility modulation, or baroreflex activation therapy are interventional strategies that might provide additional therapeutic benefits. Furthermore, cardiac regenerative therapies such as stem cell transplantation could become a new therapeutic resource in the management of heart failure due to ischemic heart disease. View this paper
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Articles (213)

  • Article
  • Open Access
9 Citations
4,286 Views
16 Pages

Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures

  • Alessandro Venuta,
  • Rosarita Nasso,
  • Armando Gisonna,
  • Roberta Iuliano,
  • Sara Montesarchio,
  • Vittoria Acampora,
  • Leandra Sepe,
  • Angelica Avagliano,
  • Rosaria Arcone and
  • Maria Rosaria Ruocco

21 April 2023

Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX inhi...

  • Article
  • Open Access
6 Citations
4,871 Views
15 Pages

Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria

  • Anna-Elisabeth Minder,
  • Xiaoye Schneider-Yin,
  • Henryk Zulewski,
  • Christoph E. Minder and
  • Elisabeth I. Minder

21 April 2023

In animal models, melanocyte-stimulating hormones (MSHs) protect the liver from various injuries. Erythropoietic protoporphyria (EPP), a metabolic disorder, leads to the accumulation of protoporphyrin (PPIX). In addition to the most prominent symptom...

  • Article
  • Open Access
3 Citations
2,448 Views
11 Pages

Comparing the Impact of COVID-19 on Vaccinated and Unvaccinated Patients Affected by Myasthenia Gravis

  • Elena Scarsi,
  • Sara Massucco,
  • Pilar M. Ferraro,
  • Arianna Cella,
  • Stefano G. Grisanti,
  • Andrea Assini,
  • Alessandro Beronio,
  • Fabio Della Cava,
  • Chiara Gemelli and
  • Marina Grandis
  • + 5 authors

21 April 2023

We evaluated 13 patients affected by myasthenia gravis (MG) who had coronavirus disease 2019 (COVID-19) before vaccination and 14 myasthenic patients who contracted severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection after vaccinat...

  • Review
  • Open Access
11 Citations
8,869 Views
20 Pages

Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection

  • María Melendo-Viu,
  • David Dobarro,
  • Sergio Raposeiras Roubin,
  • Carmen Llamas Pernas,
  • Candela Moliz Cordón,
  • Miriam Vazquez Lamas,
  • Miguel Piñón Esteban,
  • Maria Ángela Varela Martínez,
  • Emad Abu Assi and
  • Andrés Íñiguez Romo
  • + 1 author

21 April 2023

Advanced heart failure is a growing problem for which the best treatment is cardiac transplantation. However, the shortage of donors’ hearts made left ventricular assist devices as destination therapy (DT-LVAD) a highly recommended alternative:...

  • Article
  • Open Access
3 Citations
2,877 Views
18 Pages

Increased Trypanosoma cruzi Growth during Infection of Macrophages Cultured on Collagen I Matrix

  • Jorgete Logullo,
  • Israel Diniz-Lima,
  • Juliana Dutra B. Rocha,
  • Suzana Cortê-Real,
  • Elias Barbosa da Silva-Júnior,
  • Joyce Cristina Guimarães-de-Oliveira,
  • Alexandre Morrot,
  • Leonardo Marques da Fonseca,
  • Leonardo Freire-de-Lima and
  • Celio Geraldo Freire-de-Lima

21 April 2023

The interactions between cell and cellular matrix confers plasticity to each body tissue, influencing the cellular migratory capacity. Macrophages rely on motility to promote their physiological function. These phagocytes are determinant for the cont...

  • Article
  • Open Access
3 Citations
3,428 Views
13 Pages

21 April 2023

The evolution of ageusia research literature has yet to be investigated. This bibliometric study analyzed the entire ageusia research literature indexed in Web of Science, to reveal its growth and the most productive entities in terms of authors, ins...

  • Article
  • Open Access
4 Citations
2,905 Views
13 Pages

Impact of Baseline Clinical Variables on SGLT2i’s Antiproteinuric Effect in Diabetic Kidney Disease

  • Irene Capelli,
  • Danilo Ribichini,
  • Michele Provenzano,
  • Daniele Vetrano,
  • Valeria Aiello,
  • Giuseppe Cianciolo,
  • Valentina Vicennati,
  • Alessandro Tomassetti,
  • Ginevra Moschione and
  • Gaetano La Manna
  • + 1 author

21 April 2023

Introduction: Proteinuria is a major risk factor for the progression of chronic kidney disease (CKD). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) demonstrated a nephroprotective and antiproteinuric effect in people with type 2 diabetes (T2DM)...

  • Article
  • Open Access
4 Citations
2,129 Views
14 Pages

20 April 2023

Maspin is an important biomarker which was proven to be correlated to many pathological features that can help the oncologists, the surgeons and also the pathologists for choosing the personalized treatment of the patients. Maspin expression correlat...

  • Article
  • Open Access
3,393 Views
11 Pages

20 April 2023

To date, little is known about the effects of motor rehabilitation in peripheral neuropathy (PN) patients with a history of recurrent falls (RFH). This study aimed to assess balance and the activities of daily living (ADLs) in elderly lower limb PN p...

  • Review
  • Open Access
3 Citations
3,353 Views
13 Pages

The Universally Conserved Unconventional G Protein YchF Is Critical for Growth and Stress Response

  • Zhaoheng Lin,
  • Rongfang Li,
  • Zhiwei Han,
  • Yi Liu,
  • Liyang Gao,
  • Suchang Huang,
  • Ying Miao and
  • Rui Miao

20 April 2023

The ancient guanine nucleotide-binding (G) proteins are a group of critical regulatory and signal transduction proteins, widely involved in diverse cellular processes of all kingdoms of life. YchF is a kind of universally conserved novel unconvention...

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Life - ISSN 2075-1729