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Life, Volume 13, Issue 3

2023 March - 258 articles

Cover Story: The outer space environment poses several health hazards for astronauts that spend extended amounts of time in challenging environments. One factor of particular interest is that astronauts are prone to infections from bacteria that reside both on and in the astronauts’ body, which involves a whole range of bacteria that normally play an integral role in keeping the human host healthy. In this study, we show that the microgravity component of space can be replicated here on Earth through technological advancement and as a result, it can cut the cost and reduce the logistical difficulty and limited access challenges that are inherent to real space investigations and might provide a basis for investigations and discoveries to safeguard astronauts from the harsh outer space environment. View this paper
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Articles (258)

  • Article
  • Open Access
9 Citations
3,502 Views
12 Pages

Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain

  • Yuqiang Bai,
  • Chengli Hou,
  • Caiyan Huang,
  • Fei Fang,
  • Yu Dong,
  • Xin Li and
  • Dequan Zhang

22 March 2023

Tenderness is an important characteristic of meat quality. Calpastatin and calpain play important roles in meat tenderization. However, it is not clear how phosphorylation affects the regulation of calpastatin on μ-calpain and, consequently, meat...

(This article belongs to the Section Genomics and Proteomics)
  • Case Report
  • Open Access
3 Citations
4,835 Views
10 Pages

22 March 2023

The reflex auriculo-cardiac (RAC), dynamic pulse reaction (Nogier reflex), or vascular autonomic signal was proposed by Nogier. It refers to the pulse changes that can occur in the radial artery immediately after auricular acupuncture is performed. R...

(This article belongs to the Special Issue Laser Acupuncture: Past, Present and Future)
  • Communication
  • Open Access
11 Citations
8,935 Views
9 Pages

22 March 2023

In spite of the development of numerous vaccines for the prevention of COVID-19 and the approval of several drugs for its treatment, there is still a great need for effective and inexpensive therapies against this disease. Previously, we showed that...

(This article belongs to the Collection COVID-19 and Life)
  • Article
  • Open Access
1 Citations
3,859 Views
11 Pages

Complications in Patients with Chronic Type B Aortic Dissection (cTBAD)—A Long-Term Analysis

  • Darya Mohajeri,
  • Christos Rammos,
  • Konstantinos Tsagakis,
  • Thomas Schlosser,
  • Arjang Ruhparwar,
  • Tienush Rassaf,
  • Rolf Alexander Jánosi and
  • Julia Lortz

22 March 2023

Chronic type B aortic dissection (cTBAD) is a rare but challenging condition that requires individual treatment strategies. Especially the long-term therapy impacts prognosis. In this single-center retrospective study, we evaluated patients with cTBA...

(This article belongs to the Special Issue Mechanism, Diagnosis, and Treatment of Aortic Diseases)
  • Article
  • Open Access
8 Citations
6,805 Views
10 Pages

Impact of Animal By-Products on Diet Digestibility and Fecal Quality in Beagle Dogs

  • Bussarakam Chuppava,
  • Diana-Christin Siebert,
  • Christian Visscher,
  • Josef Kamphues and
  • Amr Abd El-Wahab

22 March 2023

In animal feeds and pet food, meat industry rendered by-products as a source of high-quality protein are commonly used. Among all rendered protein sources, poultry carcasses and neck meal are frequently used as ingredients in commercial pet foods due...

(This article belongs to the Section Animal Science)
  • Systematic Review
  • Open Access
34 Citations
11,915 Views
18 Pages

21 March 2023

Rheumatoid arthritis (RA) is a long-term disorder that significantly impairs somatic, emotional, and psychological functioning. The objective of this review is to identify, appraise, and synthesize the effects of psychological interventions (e.g., co...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
10 Citations
4,706 Views
12 Pages

21 March 2023

Effects of different feeding strategies on meat quality and intestinal development in pigeon squabs were investigated. 120 pairs of pigeons with two squabs each were assigned to five groups (four free-choice feeding systems and one complete feeding s...

(This article belongs to the Special Issue Trends and Outlooks in Poultry Nutrition)
  • Article
  • Open Access
5 Citations
8,798 Views
14 Pages

ZJUSAH Classification: A New Classification for Primary Brainstem Hemorrhage

  • Jingyi Zhou,
  • An Ping,
  • Jizhong Mao,
  • Yichen Gu,
  • Fengqiang Liu and
  • Anwen Shao

21 March 2023

To analyze and improve ZJUSAH classification for primary brainstem hematoma, we retrospectively reviewed 211 patients with primary brainstem hemorrhage who were admitted to our institution between January 2014 and October 2020. The primary clinical o...

(This article belongs to the Special Issue Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research)
  • Article
  • Open Access
12 Citations
4,665 Views
10 Pages

First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth

  • Tamás Ilyés,
  • Marius Pop,
  • Mihai Surcel,
  • Daria M. Pop,
  • Răzvan Rusu,
  • Ciprian N. Silaghi,
  • Gabriela C. Zaharie and
  • Alexandra M. Crăciun

21 March 2023

Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–ne...

(This article belongs to the Section Reproductive and Developmental Biology)
  • Review
  • Open Access
106 Citations
14,670 Views
15 Pages

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature

  • Galia Gentscheva,
  • Krastena Nikolova,
  • Veselina Panayotova,
  • Katya Peycheva,
  • Lubomir Makedonski,
  • Pavlo Slavov,
  • Poli Radusheva,
  • Petia Petrova and
  • Ina Yotkovska

21 March 2023

Arthrospira platensis is a filamentous cyanobacterium of the class Cyanophyceae and is the most cultivated photosynthetic prokaryote. It is used in the pharmaceutical sector, medicine and the food industry. It has a rich micro- and macro-element comp...

(This article belongs to the Collection The Role of Bioactive Natural Compounds in the Treatment of Diseases)
  • Article
  • Open Access
7 Citations
4,775 Views
19 Pages

Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight

  • Ophélie Hélissen,
  • Marc Kermorgant,
  • Sébastien Déjean,
  • Aurélie Mercadie,
  • Sophie Le Gonidec,
  • Rana Zahreddine,
  • Denis Calise,
  • Nathalie Nasr,
  • Céline Galès and
  • Anne Pavy-Le Traon
  • + 1 author

21 March 2023

Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 conscious mice...

(This article belongs to the Section Origins of Life)
  • Article
  • Open Access
21 Citations
4,931 Views
11 Pages

Molecular Characteristics and Pathogenicity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) 1 in Taiwan during 2019–2020

  • Fu-Chun Hsueh,
  • Kun-Lin Kuo,
  • Feng-Yang Hsu,
  • Sheng-Yuan Wang,
  • Hsien-Jen Chiu,
  • Meng-Tien Wu,
  • Chuen-Fu Lin,
  • Yu-Han Huang,
  • Ming-Tang Chiou and
  • Chao-Nan Lin

21 March 2023

Two variants of porcine reproductive and respiratory syndrome virus (PRRSV), PRRSV 1 and PRRSV 2, have caused abortion in pregnant sows and respiratory distress in nursery pigs worldwide. PRRSV 2 has been thoroughly researched in Taiwan since 1993; h...

(This article belongs to the Section Microbiology)
  • Communication
  • Open Access
4 Citations
3,918 Views
8 Pages

Bladder Neck Obstruction: Experience and Management in a Sperm Bank

  • Maria Neve Hirsch,
  • Francesco Pallotti,
  • Fabiana Faja,
  • Alessandra Buonacquisto,
  • Gaia Cicolani,
  • Anna Chiara Conflitti,
  • Silvia Di Chiano,
  • Andrea Lenzi,
  • Francesco Lombardo and
  • Donatella Paoli

20 March 2023

Primary Bladder Neck Obstruction (PBNO) management provides medical and surgical treatment, such as transurethral incisions that can lead to retrograde ejaculation. The aim of this study was to investigate the maintenance of anterograde ejaculation a...

(This article belongs to the Special Issue Fertility Preservation in Female and Male Benign and Malignant Conditions)
  • Review
  • Open Access
24 Citations
4,531 Views
27 Pages

Progressive Biocatalysts for the Treatment of Aqueous Systems Containing Pharmaceutical Pollutants

  • Elena Efremenko,
  • Nikolay Stepanov,
  • Olga Senko,
  • Olga Maslova,
  • Ilya Lyagin and
  • Aysel Aslanli

20 March 2023

The review focuses on the appearance of various pharmaceutical pollutants in various water sources, which dictates the need to use various methods for effective purification and biodegradation of the compounds. The use of various biological catalysts...

(This article belongs to the Special Issue Advances in Research in Biocatalysis)
  • Review
  • Open Access
7 Citations
4,064 Views
14 Pages

20 March 2023

COVID-19 is an infectious disease caused by the novel coronavirus (SARS-CoV-2) that first appeared in late 2019 and has since spread across the world. It is characterized by symptoms such as fever, cough, and shortness of breath and can lead to death...

(This article belongs to the Special Issue The Therapeutic Applications of Extracellular Vesicles)
  • Article
  • Open Access
8 Citations
4,463 Views
15 Pages

20 March 2023

Aim: We evaluated the safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) for their use with other glucose-lowering drugs and drugs for the treatment of type 2 diabetes mellitus (T2DM...

(This article belongs to the Section Pharmaceutical Science)
  • Article
  • Open Access
10 Citations
5,019 Views
10 Pages

Effectiveness of SMILE Combined with Micro-Monovision in Presbyopic Patients: A Pilot Study

  • Joaquín Fernández,
  • Federico Alonso-Aliste,
  • Noemí Burguera,
  • Julia Hernández-Lucena,
  • Jonatan Amián-Cordero and
  • Manuel Rodríguez-Vallejo

20 March 2023

Binocular summation along all defocus range after a micro-monovision procedure has scarcely been studied. The aim of this pilot study was to evaluate the efficacy of SMILE combined with different levels of micro-monovision in presbyopic patients and...

(This article belongs to the Special Issue New Horizons in Vision Science, Optometry and Ocular Surface)
  • Review
  • Open Access
34 Citations
10,303 Views
17 Pages

20 March 2023

Given the expanding elderly population in the United States and the world, it is important to understand the processes underlying both natural and pathological age-related changes in the eye. Both the anterior and posterior segment of the eye undergo...

(This article belongs to the Special Issue Eye Manifestations of Systemic Disease)
  • Article
  • Open Access
22 Citations
6,642 Views
13 Pages

Detection of Lymphatic Vessels in the Superficial Fascia of the Abdomen

  • Giovanna Albertin,
  • Laura Astolfi,
  • Caterina Fede,
  • Edi Simoni,
  • Martina Contran,
  • Lucia Petrelli,
  • Cesare Tiengo,
  • Diego Guidolin,
  • Raffaele De Caro and
  • Carla Stecco

20 March 2023

Recently, the superficial fascia has been recognized as a specific anatomical structure between the two adipose layers—the superficial adipose tissue (SAT) and the deep adipose tissue (DAT). The evaluation of specific characteristics of cells,...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
4 Citations
4,478 Views
13 Pages

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

  • Ernesto Punzi,
  • Claudio Carrubba,
  • Andrea Contegiacomo,
  • Alessandro Posa,
  • Pierluigi Barbieri,
  • Davide De Leoni,
  • Giulia Mazza,
  • Alessandro Tanzilli,
  • Alessandro Cina and
  • Roberto Iezzi
  • + 2 authors

20 March 2023

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients’ long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2–3%) have a resectable disease at diagnosis. In patients...

(This article belongs to the Section Medical Research)
  • Case Report
  • Open Access
8 Citations
6,396 Views
6 Pages

Immunoglobulin G4-Related Disease-Associated Dermatitis with Pruritus: A Positive Response to Dupilumab

  • Tyler C. Beck,
  • John Plante,
  • India Robinson,
  • Katsiaryna Khatskevich,
  • Jessica A. Forcucci and
  • Manuel Valdebran

20 March 2023

Immunoglobulin G4-related disease (IgG4-RD) is a rare fibro-inflammatory condition characterized by IgG4-expressing plasma cell infiltration of the skin and other organs, leading to profound itchiness. Oral corticosteroids are the first-line therapy...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology)
  • Article
  • Open Access
10 Citations
3,845 Views
12 Pages

Basal Cell Carcinoma—A Retrospective Descriptive Study Integrated in Current Literature

  • Carmen Giuglea,
  • Andrei Marin,
  • Iulia Gavrila,
  • Alexandra Paunescu,
  • Nicoleta Amalia Dobrete and
  • Silviu Adrian Marinescu

19 March 2023

Basal cell carcinoma (BCC) is considered to be the most common cancer in humans. It has a slow growth rhythm, and for this reason, metastases are rare. For our retrospective study, we selected 180 patients from those who underwent surgery for a varie...

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)
  • Communication
  • Open Access
7 Citations
3,890 Views
11 Pages

Understanding the Diurnal Oscillation of the Gut Microbiota Using Microbial Culture

  • Guilherme Amando,
  • André Tonon,
  • Débora Constantino,
  • Maria Paz Hidalgo,
  • Pabulo Henrique Rampelotto and
  • Francisco Montagner

19 March 2023

The composition of the gut microbiota oscillates according to the light–dark cycle. However, the existing literature demonstrates these oscillations only by molecular methods. Microbial cultures are an interesting method for studying metabolica...

(This article belongs to the Special Issue Trends in Microbiology 2024)
  • Review
  • Open Access
5 Citations
4,173 Views
14 Pages

Prostate MRI for Improving Personalized Risk Prediction of Incontinence and Surgical Planning: The Role of Membranous Urethral Length Measurements and the Use of 3D Models

  • Thierry N. Boellaard,
  • Marinus J. Hagens,
  • Hans Veerman,
  • Derya Yakar,
  • Laura S. Mertens,
  • Stijn W. T. P. J. Heijmink,
  • Henk G. van der Poel,
  • Pim J. van Leeuwen,
  • Ivo G. Schoots and
  • Margriet C. van Dijk-de Haan

19 March 2023

Prostate MRI has an important role in prostate cancer diagnosis and treatment, including detection, the targeting of prostate biopsies, staging and guiding radiotherapy and active surveillance. However, there are other ‘’less well-known&r...

(This article belongs to the Special Issue MRI in Cancer: Ongoing Developments and Controversies)
  • Brief Report
  • Open Access
3 Citations
3,478 Views
12 Pages

Patterns of Care in Patients with Basilar Artery Occlusion (BAO): A Population-Based Study

  • Mudassir Farooqui,
  • Asad Ikram,
  • Sajid Suriya,
  • Fares Qeadan,
  • Piotr Bzdyra,
  • Syed A. Quadri and
  • Atif Zafar

19 March 2023

Basilar artery occlusion (BAO) is associated with high morbidity and mortality. Endovascular therapy (EVT) has been shown to be beneficial in acute BAO patients. This retrospective observational study used the National Inpatient Sample (NIS) database...

(This article belongs to the Special Issue Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research)
  • Systematic Review
  • Open Access
21 Citations
15,125 Views
14 Pages

Melanoma Brain Metastases: A Systematic Review of Opportunities for Earlier Detection, Diagnosis, and Treatment

  • Michael Joseph Diaz,
  • Isabella Mark,
  • Daphnee Rodriguez,
  • Beata Gelman,
  • Jasmine Thuy Tran,
  • Giona Kleinberg,
  • Anna Levin,
  • Alice Beneke,
  • Kevin Thomas Root and
  • Brandon Lucke-Wold
  • + 1 author

19 March 2023

Introduction: Melanoma continues to represent the most serious skin cancer worldwide. However, few attempts have been made to connect the body of research on advanced melanoma. In the present review, we report on strides made in the diagnosis and tre...

(This article belongs to the Special Issue Therapeutic Prevention and Early Detection of Melanoma)
  • Review
  • Open Access
35 Citations
29,278 Views
14 Pages

An Overview of E-Cigarette Impact on Reproductive Health

  • Debbie Montjean,
  • Marie-Hélène Godin Pagé,
  • Marie-Claire Bélanger,
  • Moncef Benkhalifa and
  • Pierre Miron

18 March 2023

Electronic cigarettes (e-cigarettes) are often considered a “safe substitute” for conventional cigarette cessation. The composition of the fluid is not always clearly defined and shows a large variation within brands and manufacturers. Mo...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
9 Citations
3,206 Views
14 Pages

Differential Impact of Social Isolation and Space Radiation on Behavior and Motor Learning in Rats

  • Austin M. Adkins,
  • Emily M. Colby,
  • Alea F. Boden,
  • Justin D. Gotthold,
  • Ryan D. Harris,
  • Richard A. Britten,
  • Laurie L. Wellman and
  • Larry D. Sanford

18 March 2023

Future missions to Mars will expose astronauts to several physical and psychological challenges, including exposure to space radiation (SR) and periods of social isolation (SI). Each of these stressors, in addition to mission demands, can affect phys...

  • Review
  • Open Access
29 Citations
10,661 Views
13 Pages

Tension-Type Headache in Children and Adolescents

  • Valentina Baglioni,
  • Silvia Orecchio,
  • Dario Esposito,
  • Noemi Faedda,
  • Giulia Natalucci and
  • Vincenzo Guidetti

18 March 2023

In pediatric neurology, tension-type headache (TTH) represents a very common type of primary headache during the pediatric age. Despite the high prevalence of TTH, this diagnosis is often underestimated in childhood, with relevant difficulties in the...

(This article belongs to the Special Issue The Other Pediatric Primary Headaches)
  • Article
  • Open Access
14 Citations
3,636 Views
18 Pages

Chlorophyll Meter: A Precision Agricultural Decision-Making Tool for Nutrient Supply in Durum Wheat (Triticum turgidum L.) Cultivation under Drought Conditions

  • Anteneh Agezew Melash,
  • Bekir Bytyqi,
  • Muhoja Sylivester Nyandi,
  • Attila Miklós Vad and
  • Éva Babett Ábrahám

17 March 2023

How crop biodiversity adapts to drought conditions and enhances grain yield became the most important issue facing agronomists and plant breeders at the turn of the century. Variations in genetic response, inadequacy of nutrients in the soil, and ins...

(This article belongs to the Special Issue Updates on Abiotic Stress Signaling and Response in Plants)
  • Review
  • Open Access
3 Citations
6,418 Views
12 Pages

Host–Parasite Coevolution in Primates

  • Dietmar Zinner,
  • Filipa M. D. Paciência and
  • Christian Roos

17 March 2023

Organisms adapt to their environment through evolutionary processes. Environments consist of abiotic factors, but also of other organisms. In many cases, two or more species interact over generations and adapt in a reciprocal way to evolutionary chan...

(This article belongs to the Collection Feature Papers in Microbiology)
  • Article
  • Open Access
22 Citations
4,757 Views
20 Pages

Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters

  • Merve Acikel-Elmas,
  • Salva Asma Algilani,
  • Begum Sahin,
  • Ozlem Bingol Ozakpinar,
  • Mert Gecim,
  • Kutay Koroglu and
  • Serap Arbak

17 March 2023

Background: the aim of this study was to investigate the effects of apocynin (APO) on hormone levels, the blood-testis barrier, and oxidative biomarkers in monosodium glutamate (MSG) induced testicular degeneration. Methods: Sprague Dawley male rats...

(This article belongs to the Topic Oxidative Stress and Inflammation)
  • Article
  • Open Access
15 Citations
4,070 Views
14 Pages

17 March 2023

Antibiotic resistance is a global health problem, causing not only an increased mortality rate of bacterial infections but also economic losses due to, among other reasons, the need for longer hospital stays. Listeria monocytogenes is one of the food...

(This article belongs to the Special Issue Bacteriocin, Antimicrobial Peptide, and Antibiotics: Current Insights and Application)
  • Article
  • Open Access
11 Citations
7,901 Views
17 Pages

Do Medical Universities Students Use Cognitive Enhancers while Learning?—Conclusions from the Study in Poland

  • Anna Merwid-Ląd,
  • Michał Passon,
  • Paweł Drymluch,
  • Maciej Głuszyński,
  • Adam Szeląg and
  • Agnieszka Matuszewska

17 March 2023

Background: Stress and everyday problems may impact memory and cognition. Therefore, many people use cognitive enhancers (CEs), sold for prescription, as over-the-counter drugs, or dietary supplements, believing they may help with everyday functionin...

(This article belongs to the Special Issue Nutrition and Dietary Pattern Associated with Diseases)
  • Article
  • Open Access
11 Citations
10,843 Views
12 Pages

New Fossil Evidence Suggests That Angiosperms Flourished in the Middle Jurassic

  • Lei Han,
  • Ya Zhao,
  • Ming Zhao,
  • Jie Sun,
  • Bainian Sun and
  • Xin Wang

17 March 2023

Angiosperms are a group of plants with the highest rate of evolution, the largest number of species, the widest distribution and the strongest adaptability. Needless to say, angiosperms are the most important group for the humans. The studies on the...

(This article belongs to the Special Issue Recent Research on Palaeontology)
  • Review
  • Open Access
10 Citations
3,862 Views
19 Pages

17 March 2023

Neuroblastoma is a paediatric malignancy originating from the neural crest that commonly occurs in the abdomen and adrenal gland, leading to cancer-related deaths in children. Distant metastasis can be encountered at diagnosis in greater than half of...

(This article belongs to the Section Physiology and Pathology)
  • Communication
  • Open Access
7 Citations
4,544 Views
13 Pages

Estimated Prevalence of Tuberculosis in Ruminants from Slaughterhouses in Constantine Province (Northeastern Algeria): A 10-Year Retrospective Survey (2011–2020)

  • Nadir Boudjlal Dergal,
  • Mohamed Ghermi,
  • Kálmán Imre,
  • Adriana Morar,
  • Ulaș Acaroz,
  • Damla Arslan-Acaroz,
  • Viorel Herman and
  • Abdelhanine Ayad

17 March 2023

Tuberculosis (TB) is considered one of the most widespread and devastating zoonotic diseases in low-income countries, with a cosmopolitan distribution. The aim of this 10-year retrospective survey (from 2011 to 2020) was to determine the frequency of...

(This article belongs to the Section Epidemiology)
  • Review
  • Open Access
25 Citations
8,003 Views
22 Pages

17 March 2023

Exploring austere environments required a reimagining of resource acquisition and utilization. Cyanobacterial in situ resources utilization (ISRU) and biological life support system (BLSS) bioreactors have been proposed to allow crewed space missions...

(This article belongs to the Special Issue Advances in Space Biomedicine and Disease Pathogenesis)
  • Systematic Review
  • Open Access
7 Citations
2,737 Views
15 Pages

17 March 2023

Background: Recalcitrant neovascular age-related macular degeneration (rnAMD) despite intensive intravitreal anti-neovascular endothelial growth factor (VEGF) treatment, can be handled by switching to another anti-VEGF agent. This first systematic re...

(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment)
  • Article
  • Open Access
10 Citations
15,277 Views
12 Pages

The Effects of Glutathione on Clinically Essential Fertility Parameters in a Bleomycin Etoposide Cisplatin Chemotherapy Model

  • Hale Bayram,
  • Yaprak Donmez Cakil,
  • Mustafa Erinc Sitar,
  • Gamze Demirel,
  • Belgin Selam and
  • Mehmet Cincik

17 March 2023

Chemotherapeutic agents used in the treatment of testicular cancer cause damage to healthy tissues, including the testis. We investigated the effects of glutathione on sperm DNA integrity and testicular histomorphology in bleomycin etoposide cisplati...

(This article belongs to the Special Issue Fertility Preservation in Female and Male Benign and Malignant Conditions)
  • Article
  • Open Access
6 Citations
3,288 Views
13 Pages

Executive Function and Working Memory Deficits in Females with Fragile X Premutation

  • Osnat Segal,
  • Tamar Kowal,
  • Yonit Banet-Levi and
  • Lidia V. Gabis

17 March 2023

The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fra...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
28 Citations
8,359 Views
17 Pages

The Urinary Microbiome and Bladder Cancer

  • Nassib Abou Heidar,
  • Tariq A. Bhat,
  • Usma Shabir and
  • Ahmed A. Hussein

17 March 2023

Bladder cancer is the 10th most common cancer worldwide. Approximately 75% of patients with bladder cancer will present with non-muscle invasive disease. Patients are usually treated with transurethral resection of bladder tumor (TURBT), in addition...

(This article belongs to the Special Issue Urinary Microbiome and Genitourinary System Disorders)
  • Article
  • Open Access
10 Citations
4,798 Views
12 Pages

Degree of Actinic Elastosis Is a Surrogate of Exposure to Chronic Ultraviolet Radiation and Correlates More Strongly with Cutaneous Squamous Cell Carcinoma than Basal Cell Carcinoma

  • Konstantin Drexler,
  • Hans Drexler,
  • Sigrid Karrer,
  • Michael Landthaler,
  • Sebastian Haferkamp,
  • Florian Zeman,
  • Mark Berneburg and
  • Dennis Niebel

17 March 2023

(1) Background: Keratinocyte cancer (KC) is associated with exposure to ultraviolet (UV) radiation. However, data are controversial as to whether chronic UV exposure or high intermittent UV exposure are key drivers of carcinogenesis in cutaneous squa...

(This article belongs to the Special Issue Mechanism, Diagnostic and Therapeutic Novelties in Dermatology)
  • Article
  • Open Access
2 Citations
3,234 Views
12 Pages

Laser Therapy Changes the Expression of Matrix Metalloproteinases in Bleomycin-Induced Skin Fibrosis

  • Anna G. Soboleva,
  • Vladimir V. Sobolev,
  • Mari M. Karapetyan,
  • Alexandre Mezentsev,
  • Olga I. Rud’ko,
  • Evgenia D. Davydova,
  • Julia A. Mogulevtseva,
  • Olga V. Zhukova and
  • Irina M. Korsunskaya

16 March 2023

Matrix metalloproteinases (MMPs) are often considered biomarkers of skin fibrosis. At the early stages of the pathological process, an elevation of their enzymatic activity causes significant changes in the composition of the extracellular matrix. MM...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
14 Citations
6,813 Views
16 Pages

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

  • Cătălina Roxana Ferea,
  • Stejara Nicoleta Mihai,
  • Gabriela Balan,
  • Minerva Codruta Badescu,
  • Dana Tutunaru and
  • Alin Laurențiu Tatu

16 March 2023

Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or pla...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
14 Citations
16,841 Views
13 Pages

Vitamin D3 Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals

  • Eva Dědečková,
  • Roman Viták,
  • Michal Jirásko,
  • Markéta Králová,
  • Ondřej Topolčan,
  • Ladislav Pecen,
  • Tomáš Fürst,
  • Pavel Brož and
  • Radek Kučera

16 March 2023

Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800–2000 IU/day. The aim of our study was to determine whether doses of 1000 IU o...

(This article belongs to the Special Issue Feature Papers in Medical Research)
  • Article
  • Open Access
41 Citations
6,819 Views
13 Pages

Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of Artemisia annua L. (Asteraceae) Native to Mediterranean Area

  • Khalid Chebbac,
  • Zineb Benziane Ouaritini,
  • Abdelfattah El Moussaoui,
  • Mohammed Chalkha,
  • Soufyane Lafraxo,
  • Yousef A. Bin Jardan,
  • Hiba-Allah Nafidi,
  • Mohammed Bourhia and
  • Raja Guemmouh

16 March 2023

Artemisia annua (AA) is an aromatic plant belonging to the Asteraceae family, which has long been known for its several medicinal virtues. In addition, essential oils (EOs) extracted from AA have a wide range of therapeutic properties. Therefore, thi...

(This article belongs to the Collection The Role of Bioactive Natural Compounds in the Treatment of Diseases)
  • Review
  • Open Access
11 Citations
5,438 Views
14 Pages

16 March 2023

Resistant hypertension (RH) is defined as the failure to achieve blood pressure control despite using triple combination therapy with a renin-angiotensin system inhibitor (RAS-i), a calcium antagonist, and a diuretic. The endothelin (ET) system is im...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
12 Citations
7,649 Views
13 Pages

Infectious Microorganisms Seen as Etiologic Agents in Parkinson’s Disease

  • Stuparu Alina Zorina,
  • Sanda Jurja,
  • Mihaela Mehedinti,
  • Ana-Maria Stoica,
  • Dana Simona Chita,
  • Stuparu Alexandru Floris and
  • Any Axelerad

16 March 2023

Infections represent a possible risk factor for parkinsonism and Parkinson’s disease (PD) based on information from epidemiology and fundamental science. The risk is unclear for the majority of agents. Moreover, the latency between infection an...

(This article belongs to the Section Physiology and Pathology)

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Life - ISSN 2075-1729