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Genes, Volume 14, Issue 12

December 2023 - 129 articles

Cover Story: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive heterotopic ossification, wherein soft connective tissues undergo pathological transformation into bone structures. This write-up offers a comprehensive overview of the contemporary understanding of FOP’s complex pathobiology, underscored by advances in molecular genetics and proteomic studies. We delve into targeted therapy, spanning genetic therapeutics, enzymatic and transcriptional modulation, stem cell therapies, and innovative immunotherapies. We also highlight the intricate complexities surrounding clinical trial design for ultra-rare disorders like FOP, addressing fundamental statistical limitations, ethical conundrums, and methodological advancements essential for the success of interventional studies. View this paper
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Articles (129)

  • Article
  • Open Access
4 Citations
3,578 Views
14 Pages

Role of RPA Phosphorylation in the ATR-Dependent G2 Cell Cycle Checkpoint

  • Shengqin Liu,
  • Brendan M. Byrne,
  • Thomas N. Byrne and
  • Gregory G. Oakley

13 December 2023

Cells respond to DNA double-strand breaks by initiating DSB repair and ensuring a cell cycle checkpoint. The primary responder to DSB repair is non-homologous end joining, which is an error-prone repair pathway. However, when DSBs are generated after...

  • Article
  • Open Access
4 Citations
2,024 Views
14 Pages

Phenotypic and Proteomic Insights into Differential Cadmium Accumulation in Maize Kernels

  • Huanle Guo,
  • Min Deng,
  • Feng Yu,
  • Han Li,
  • Zhongyang Cao,
  • Qiang Zeng,
  • Zhihui Chen,
  • Hongbing Luo and
  • Bin Tang

13 December 2023

The contamination of agricultural soil with cadmium (Cd), a heavy metal, poses a significant environmental challenge, affecting crop growth, development, and human health. Previous studies have established the pivotal role of the ZmHMA3 gene, a P-typ...

  • Article
  • Open Access
1 Citations
1,757 Views
17 Pages

13 December 2023

Salt stress is a significant environmental factor affecting plant growth and development, with NaCl stress being one of the most common types of salt stress. The halophyte, Tamarix ramosissima Ledeb (T. ramosissima), is frequently utilized for the af...

  • Article
  • Open Access
3 Citations
2,807 Views
18 Pages

12 December 2023

Studying the molecular mechanisms of the pathogenesis of Parkinson’s disease (PD) is critical to improve PD treatment. We used OpenArray technology to assess gene expression in the substantia nigra (SN) cells of mice in a 1-methyl-4-phenyl-1,2,...

  • Article
  • Open Access
6 Citations
2,259 Views
15 Pages

Identification of Superior Haplotypes and Haplotype Combinations for Grain Size- and Weight-Related Genes for Breeding Applications in Rice (Oryza sativa L.)

  • Gang Liu,
  • Dongfeng Qiu,
  • Yuxia Lu,
  • Yan Wu,
  • Xuesong Han,
  • Yaru Jiao,
  • Tingbao Wang,
  • Jinsong Yang,
  • Aiqing You and
  • Jianguo Chen
  • + 1 author

12 December 2023

The identification of superior haplotypes and haplotype combinations is essential for haplotype-based breeding (HBB), which provides selection targets for genomics-assisted breeding. In this study, genotypes of 42 functional genes in rice were analyz...

  • Article
  • Open Access
4 Citations
2,510 Views
16 Pages

12 December 2023

The Supersymmetry Genetic code (SSyGC) table is based on five physicochemical symmetries: (1) double mirror symmetry on the principle of the horizontal and vertical mirror symmetry axis between all bases (purines [A, G) and pyrimidines (U, C)] and (2...

  • Article
  • Open Access
2 Citations
2,368 Views
16 Pages

Genetic Origin and Introgression Pattern of Pingliang Red Cattle Revealed Using Genome-Wide SNP Analyses

  • Yuanqing Wang,
  • Jun Ma,
  • Jing Wang,
  • Lupei Zhang,
  • Junwei Hu,
  • Minghao Ma,
  • Lingyang Xu,
  • Yan Chen,
  • Bo Zhu and
  • Zezhao Wang
  • + 3 authors

11 December 2023

The Pingliang red cattle, an outstanding indigenous resource in China, possesses an exceptional breeding value attributed to its tender meat and superior marbling quality. Currently, research efforts have predominantly concentrated on exploring its m...

  • Article
  • Open Access
5 Citations
2,332 Views
11 Pages

Characterization of the Complete Mitochondrial Genome and Phylogenetic Analyses of Eurytrema coelomaticum (Trematoda: Dicrocoeliidae)

  • Fuqiang Huang,
  • Xin Li,
  • Bijin Ye,
  • Yule Zhou,
  • Zhisheng Dang,
  • Wenqiang Tang,
  • Long Wang,
  • Haoji Zhang,
  • Wenting Chui and
  • Jun Kui

11 December 2023

Eurytrema coelomaticum, a pancreatic fluke, is recognized as a causative agent of substantial economic losses in ruminants. This infection, commonly referred to as eurytrematosis, is a significant concern due to its detrimental impact on livestock pr...

  • Review
  • Open Access
15 Citations
3,970 Views
13 Pages

Genomic Insights into Molecular Regulation Mechanisms of Intramuscular Fat Deposition in Chicken

  • Yuzhu Cao,
  • Yuxin Xing,
  • Hongbo Guan,
  • Chenglin Ma,
  • Qihui Jia,
  • Weihua Tian,
  • Guoxi Li,
  • Yadong Tian,
  • Xiangtao Kang and
  • Xiaojun Liu
  • + 1 author

10 December 2023

Intramuscular fat (IMF) plays an important role in the tenderness, water-holding capacity, and flavor of chicken meat, which directly affect meat quality. In recent years, regulatory mechanisms underlying IMF deposition and the development of effecti...

  • Article
  • Open Access
4 Citations
2,067 Views
15 Pages

miR-302d Targeting of CDKN1A Regulates DNA Damage and Steroid Hormone Secretion in Bovine Cumulus Cells

  • Jianbo Liu,
  • Jiabao Zhang,
  • Yi Zheng,
  • Guokun Zhao,
  • Hao Jiang and
  • Bao Yuan

10 December 2023

(1) Background: DNA damage in cumulus cells hinders oocyte maturation and affects steroid hormone secretion. It is crucial to identify the key factors that regulate cellular DNA damage and steroid hormone secretion. (2) Methods: Treatment of bovine c...

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Genes - ISSN 2073-4425