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Review

The Intersection of Purine and Mitochondrial Metabolism in Cancer

by
Humberto De Vitto
,
Danushka B. Arachchige
,
Brian C. Richardson
and
Jarrod B. French
*
Division of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
*
Author to whom correspondence should be addressed.
Cells 2021, 10(10), 2603; https://doi.org/10.3390/cells10102603
Submission received: 26 August 2021 / Revised: 20 September 2021 / Accepted: 23 September 2021 / Published: 30 September 2021
(This article belongs to the Special Issue Ovary and Brain)
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Abstract

Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.
Keywords: purines; mitochondrial metabolism; amino acids; metabolic reprogramming; cancers purines; mitochondrial metabolism; amino acids; metabolic reprogramming; cancers

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MDPI and ACS Style

De Vitto, H.; Arachchige, D.B.; Richardson, B.C.; French, J.B. The Intersection of Purine and Mitochondrial Metabolism in Cancer. Cells 2021, 10, 2603. https://doi.org/10.3390/cells10102603

AMA Style

De Vitto H, Arachchige DB, Richardson BC, French JB. The Intersection of Purine and Mitochondrial Metabolism in Cancer. Cells. 2021; 10(10):2603. https://doi.org/10.3390/cells10102603

Chicago/Turabian Style

De Vitto, Humberto, Danushka B. Arachchige, Brian C. Richardson, and Jarrod B. French. 2021. "The Intersection of Purine and Mitochondrial Metabolism in Cancer" Cells 10, no. 10: 2603. https://doi.org/10.3390/cells10102603

APA Style

De Vitto, H., Arachchige, D. B., Richardson, B. C., & French, J. B. (2021). The Intersection of Purine and Mitochondrial Metabolism in Cancer. Cells, 10(10), 2603. https://doi.org/10.3390/cells10102603

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