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Cancers, Volume 10, Issue 6 (June 2018)
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Cover Story (view full-size image) Until today, older patients with high-risk myelodysplastic syndrome (MDS) and acute myeloid [...] Read more. Until today, older patients with high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have poor outcomes when treated with conventional treatment strategies. Response after a first-line treatment with hypomethylating agents (HMA) occurs in less than 50% of these patients. In our review, we focus on upcoming new treatment strategies in the field of HMA-based combination strategies. One of the current most promising approaches is preventing HMA resistance by using checkpoint inhibitors. We are sure that these new treatment options will guide the future of clinical research. Recent data also suggest a potential renaissance of intensive treatment strategies, such as therapies based on CPX-351. View this paper.